Toxicology.
Publisher:
Elsevier/North-Holland.. Limerick : Elsevier
Frequency: Thirty three no. a year, 1999-
Country: Ireland
Language: English
Start Year:1973 -
ISSN:
0300-483X (Print)
1879-3185 (Electronic)
0300-483X (Linking)
1879-3185 (Electronic)
0300-483X (Linking)
Impact Factor
4.5
2022
| NLM ID: | 0361055 |
| (DNLM): | T13820000(s) |
| (OCoLC): | 01792578 |
| Coden: | TXCYAC |
| Classification: | W1 TO896 |
Species comparison of vitamin K1 2,3-epoxide reductase activity in vitro: kinetics and warfarin inhibition. A comparative study of vitamin K(1) 2,3-epoxide reductase (VKOR) activity in vitro was conducted across species. The apparent kinetic constants K(m app), V(max), and Cl(int app) were determined in bovine, canine, equine, human, murine, ovine, porcine, and rat hepatic microsomes. In addition to these enzyme kinetic constants, the IC(50) of warfarin for VKOR was determined in human, murine, porcine, and rat hepatic microsomes. Interspecies differences were observed when comparing the K(m app) (range, 2.41-6.46 microM), V(max) (range, 19.5-85.7 nmol/mg/min), and Cl(int app) (range, 8.2-18.4 ml/mg...