Urology.
Publisher:
Professional Medical Services Co.. New York : Elsevier Science
Frequency: Monthly
Country: United States
Language: English
Author(s):
International Society of Urology.
Start Year:1973 -
ISSN:
0090-4295 (Print)
1527-9995 (Electronic)
0090-4295 (Linking)
1527-9995 (Electronic)
0090-4295 (Linking)
Impact Factor
2.1
2022
| NLM ID: | 0366151 |
| (OCoLC): | 01785123 |
| (DNLM): | U04820000(s) |
| Coden: | URGYAZ |
| LCCN: | 73641285 |
| Classification: | W1 UR679P |
Muscarinic receptor subtypes mediate vasorelaxation in isolated horse deep dorsal penile vein. To investigate the effect of acetylcholine (ACh) on horse deep dorsal penile vein and to characterize the muscarinic receptor subtypes involved in this response. Methods: Vein rings were mounted in an organ bath chamber, and the isometric tension was recorded. Results: In phenylephrine-contracted veins, ACh (1 nM to 1 microM) induced endothelium-dependent relaxation. The muscarinic receptor antagonist, atropine, produced parallel rightward shifts of the ACh response curves (pA2 = 10.04; pK(B) = 9.98). Carbachol (10 nM to 100 microM) also evoked relaxation in the vein segments, but showed a low...