Wellcome open research.
Publisher:
Wellcome Trust,
Country: England
Language: English
Author(s):
Wellcome Trust (London, England),
Start Year:2016 -
Identifiers
| ISSN: | 2398-502X (Electronic) 2398-502X (Linking) |
| NLM ID: | 101696457 |
| (OCoLC): | 990147075 |
| LCCN: | 2017243147 |
| Classification: | W1 |
Intrathecal Immunoglobulin for treatment of adult patients with tetanus: A randomized controlled 2×2 factorial trial. Despite long-standing availability of an effective vaccine, tetanus remains a significant problem in many countries. Outcome depends on access to mechanical ventilation and intensive care facilities and in settings where these are limited, mortality remains high. Administration of tetanus antitoxin by the intramuscular route is recommended treatment for tetanus, but as the tetanus toxin acts within the central nervous system, it has been suggested that intrathecal administration of antitoxin may be beneficial. Previous studies have indicated benefit, but with the exception of one small trial n...
Identification of Equid herpesvirus 2 in tissue-engineered equine tendon. Incidental findings of virus-like particles were identified following electron microscopy of tissue-engineered tendon constructs (TETC) derived from equine tenocytes. We set out to determine the nature of these particles, as there are few studies which identify virus in tendons , and their presence could have implications for tissue-engineering using allogenic grafts. Virus particles were identified in electron microscopy of TETCs. Virion morphology was used to initially hypothesise the virus identity. Next generation sequencing was implemented to identify the virus. A pan herpesvirus PCR ...