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Topic:Buprenorphine
Buprenorphine is an opioid analgesic used in veterinary medicine for pain management in horses. It acts on the central nervous system by binding to opioid receptors, providing analgesic effects. Buprenorphine is often administered for its efficacy in managing moderate to severe pain, particularly in postoperative and traumatic conditions. The pharmacokinetics, dosage, and administration routes of buprenorphine in equine patients are subjects of ongoing research, as they can vary based on the horse's condition and individual response. This page compiles peer-reviewed research studies and scholarly articles that investigate the pharmacological properties, therapeutic applications, and safety profile of buprenorphine in equine medicine.
Combined use of sedatives and opiates in horses. The effects of four intravenous combinations, xylazine (0.7 mg/kg)/methadone (0.1 mg/kg), xylazine (0.7 mg/kg)/buprenorphine (0.004 and 0.006 mg/kg) and acepromazine (0.05 mg/kg)/buprenorphine (0.006 mg/kg) on arterial blood pressure, central venous pressure, heart rate, respiratory rate and blood gases were studied in four experimental ponies. With xylazine/buprenorphine and xylazine/methadone onset of sedation was rapid and obvious and although no surgical or diagnostic procedures were carried out, sedation was judged to be satisfactory for the next 30 to 40 minutes. Onset of sedation after ...
Clinical effect of buprenorphine or butorphanol, in combination with detomidine and diazepam, on sedation and postoperative pain after cheek tooth extraction in horses. The objective of this study was to compare effects of butorphanol (BUT) or buprenorphine (BUP), in combination with detomidine and diazepam, on the sedation quality, surgical conditions, and postoperative pain control after cheek tooth extraction in horses, randomly allocated to 2 treatment groups (BUT: = 20; BUP: = 20). A bolus of detomidine (15 μg/kg, IV) was followed by either BUP (7.5 μg/kg, IV) or BUT (0.05 mg/kg, IV). After 20 min, diazepam (0.01 mg/kg, IV) was administered and sedation was maintained with a detomidine IV infusion (20 μg/kg/h), with rate adjusted based on scores to ...
