Topic:Melioidosis
Melioidosis is an infectious disease caused by the bacterium *Burkholderia pseudomallei*, which can affect a wide range of animal species, including horses. This disease is endemic in tropical and subtropical regions, particularly in Southeast Asia and northern Australia. In horses, melioidosis can present with a variety of clinical signs, such as fever, respiratory distress, and abscess formation. The disease is transmitted through contact with contaminated soil or water, and diagnosis often involves bacterial culture and serological testing. Treatment typically requires prolonged antibiotic therapy. This page compiles peer-reviewed research studies and scholarly articles that explore the epidemiology, pathogenesis, clinical presentation, and management of melioidosis in horses.
Glanders and Melioidosis Glanders is an infectious disease caused by Burkholderia mallei, a gram-negative aerobic nonmotile bacterium. Melioidosis is an infectious disease caused by Burkholderia pseudomallei, a gram-negative aerobic, motile bacterium. The two bacteria are closely related, and both can cause disease in animals and humans. Historically, glanders was a common disease of horses, donkeys, and mules. Melioidosis was first described as a case series of 38 patients in Rangoon, Burma, by pathologist Alfred Whitmore in 1912.
[Comparative analysis of LAMP and Real Time PCR methods to detect pathogens of glanders and meliodosis.]. Results of detection of Burkholderia mallei and Burkholderia pseudomallei DNA strains by LAMP (Loop-mediated Isothermal Amplification) and Real Time PCR are shown. It has been revealed that, in Real Time PCR, primers steadily detected DNA of those microorganism for the sequences of which they were designed. The above mentioned primers did not detect DNA of heterologous strains. During LAMP method no set of primers showed high analytical sensitivity and specificity. Primers did not detected DNA of all the strains under research to target genes of which they were not intended, but they were capa...