Topic:Methylcellulose
Methylcellulose is a chemically modified cellulose derivative used in various applications, including equine health. In the context of horses, methylcellulose serves primarily as a laxative or bulking agent to aid in the management of gastrointestinal conditions. It is a water-soluble polymer that can increase the moisture content and bulk of the intestinal contents, facilitating smoother passage through the digestive tract. Methylcellulose is often considered in the management of conditions such as impaction colic, where it may help to alleviate blockages by softening and increasing the volume of intestinal contents. This page compiles peer-reviewed research studies and scholarly articles that explore the pharmacokinetics, efficacy, and safety of methylcellulose use in equine gastrointestinal health.
Pharmacokinetics of an orally administered methylcellulose formulation of gallium maltolate in neonatal foals. Gallium is a trivalent semi-metal with anti-microbial effects because of its incorporation into crucial iron-dependent reproductive enzyme systems. Gallium maltolate (GaM) provides significant gallium bioavailability to people and mice following oral administration and to neonatal foals following intragastric administration. To study the prophylactic and therapeutic effects of GaM against Rhodococcus equi pneumonia in foals, we developed a methylcellulose formulation of GaM (GaM-MCF) for oral administration to neonatal foals. Normal neonatal foals were studied. Six foals received 20 mg/kg and ...
Effects of sodium hyaluronate on tendon healing and adhesion formation in horses. Sodium hyaluronate reduces adhesions after tendon repair in rodents and dogs, and has been used in limited clinical trials in people. To evaluate its effect on tendon healing and adhesion formation in horses and to compare these effects with those of a compound of similar visco-elastic properties, a study was performed in horses, using a model of collagenase injection in the flexor tendons within the digital sheath. Eight clinically normal horses were randomly allotted to 2 groups. Adhesion formation between the deep digital flexor tendon and the tendon sheath at the pastern region was induced...