Topic:Thromboxane
Thromboxane is a bioactive lipid compound derived from arachidonic acid through the cyclooxygenase pathway in horses. It is primarily produced by platelets and plays a role in the regulation of hemostasis and thrombosis by promoting platelet aggregation and vasoconstriction. Thromboxane is involved in various physiological and pathological processes, including inflammation and vascular injury. In equine medicine, the study of thromboxane can provide insights into conditions related to coagulation disorders and cardiovascular health. This page compiles peer-reviewed research studies and scholarly articles that explore the biosynthesis, function, and clinical implications of thromboxane in equine physiology and pathology.
Thromboxane, prostaglandin I2 (epoprostenol), and the hemodynamic changes in equine endotoxin shock. This study had 2 objectives: (i) to correlate plasma thromboxane and prostaglandin I2 (epoprostenol) concentrations with hemodynamic changes occurring in equine endotoxin shock, and (ii) to determine the effects of flunixin meglumine on plasma concentrations of these prostaglandins relative to hemodynamic changes. Shock was induced in 2 groups, each of 4 anesthetized ponies, and in a 3rd group of 2 ponies. Group A ponies were given endotoxin only (and were not treated), and group B ponies were given endotoxin and then treated with flunixin meglumine. Group C ponies were treated with flunixin m...