Topic:Thyrotropin-Releasing Hormone
Thyrotropin-Releasing Hormone (TRH) is a tripeptide hormone synthesized in the hypothalamus of horses. It primarily functions to stimulate the release of thyroid-stimulating hormone (TSH) from the anterior pituitary gland, which in turn regulates the production of thyroid hormones. TRH plays a role in the endocrine system and is involved in the regulation of metabolism, growth, and development. In equine medicine, TRH stimulation tests are utilized to assess thyroid function and diagnose disorders related to the hypothalamic-pituitary-thyroid axis. This page compiles peer-reviewed research studies and scholarly articles that explore the physiological role, regulatory mechanisms, and diagnostic applications of thyrotropin-releasing hormone in horses.
Effects of pituitary stalk transection on endocrine function in Pony mares. The pituitary stalk was transected in 10 Pony mares by a surgical approach that involved dorsal reflection of the brain and micro-dissection from the ventro-lateral aspect of the pituitary. Diabetes insipidus was the most immediate and marked result, requiring extensive electrolyte and antidiuretic therapy for approximately 48 h after operation. Fluid stasis then developed and no further supportive measures were necessary. Endocrine challenge tests with GnRH and TRH before and after stalk transection indicated a loss of responsiveness (GnRH) or suppressed responsiveness (TRH) after the operati...