24-hour renal clearance and excretion of endogenous substances in the mare.
Abstract: Urine samples were obtained from 6 healthy mares. During a 2-day acclimation period, mares were kept in stalls, fed sweet feed and mixed grass hay, and allowed free access to water and trace mineral salt. The mares were crosstied in their stalls within reach of hay, salt, and water for 24 hours during which urine was obtained by constant flow via indwelling Foley catheters. Twenty-four-hour urine production was 7,649 to 11,904 ml/day (mean = 9,212 +/- 1,9285) or 14.7 to 25.1 mlĝ/day. (mean = 19.3 +/- 4.1). Urinary excretion and clearance of electrolytes and protein were determined from aliquots of well-mixed, pooled 24-hour urine samples. These values were sodium (Na) = 0 to 1.7 mEq/kg/day (mean = 0.4 +/- 0.7), chloride (Cl) = 2.0 to 4.2 mEq/kg/day (mean = 3.0 +/- 0.8), phosphorous (P) = 0.03 to 0.12 mg/kg/day (mean = 0.07 +/- 0.3), potassium (K) = 3.7 to 6.5 mEq/kg/day (mean = 5.3 +/- 1.4), and creatinine (Cr) = 32.1 to 53.9 mg/kg/day (mean = 40.3 +/- 8.5). Fractional excretions of electrolytes were Na = 0% to 0.46% (mean = 0.1 +/- 0.2), Cl = 0.48% to 1.64% (mean = 1.14 +/- 0.45), P = 0.04% to 0.16% (mean = 0.08 +/- 0.04), and K = 23.9% to 75.1% (mean = 51.7 +/- 17.3). Average clearances (ml/hr/kg) were Na = 0.12 +/- 0.19, K = 64.1 +/- 17.1, Cl = 1.21 +/- 0.33, and P = 0.09 +/- 0.51. Average endogenous Cr clearance (ml/min/kg) was 1.92 +/- 0.51.(ABSTRACT TRUNCATED AT 250 WORDS)
Publication Date: 1986-06-01 PubMed ID: 3729136
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research investigates the 24-hour renal clearance and excretion rates of endogenous substances such as electrolytes and proteins in healthy mares. Urine samples were collected and analyzed, and the study provides valuable measurements and insights for the average excretion and clearance rates of various important substances.
Objective of the Study and Methodology
- The primary aim of this research was to study and understand the renal clearance and excretion levels of different endogenous substances, including electrolytes and protein, in healthy adult mares over a period of 24 hours.
- Detailed urine samples from 6 healthy adult mares were collected within a specified environment. The mares were acclimated within a stall environment for 2 days before the collection, where they were fed sweet feed and mixed grass hay, and were given unrestricted access to water and trace mineral salt.
- During the 24-hour urine collection period, the mares were crosstied within their stalls, within reach of hay, salt, and water. Urine was collected using indwelling Foley catheters, which allowed for constant flow and more accurate 24-hour urine production measurements.
Findings of the Study
- The 24-hour urine production was found to range between 7,649 to 11,904 ml/day, with a mean value of 9,212 ml/day. The urinary excretion and clearance of various substances were determined from pooled and mixed samples of this 24-hour urine.
- The mean values of urinary excretion and clearance of various electrolytes were determined. These included sodium (Na), chloride (Cl), phosphorous (P), potassium (K), and creatinine (Cr).
- Additionally, the study also determined the average fractional excretion of electrolytes, which is an indicator of how much portion of a substance filtered by the kidney is eventually excreted in the urine.
- The average clearances for sodium, potassium, chloride, and phosphorous were also calculated. The average endogenous Cr clearance, which is an important measure of how well the kidneys are filtering out waste products from the body, was also determined.
Significance of the Study
- This study provides valuable measurements and insights into the renal clearance and excretion rates of important endogenous substances in healthy adult mares.
- The study’s data can be used as a reference in veterinary healthcare and research, to understand normal renal function and to detect potential abnormalities or diseases in mares.
Cite This Article
APA
Kohn CW, Strasser SL.
(1986).
24-hour renal clearance and excretion of endogenous substances in the mare.
Am J Vet Res, 47(6), 1332-1337.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Chlorides / urine
- Creatinine / urine
- Electrolytes / urine
- Female
- Horses / urine
- Kidney / physiology
- Phosphorus / urine
- Potassium / urine
- Sodium / urine
Citations
This article has been cited 1 times.- Iwahori T, Ueshima H, Torii S, Saito Y, Kondo K, Tanaka-Mizuno S, Arima H, Miura K. Diurnal variation of urinary sodium-to-potassium ratio in free-living Japanese individuals.. Hypertens Res 2017 Jul;40(7):658-664.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
