A case of interstitial pneumonia associated with Pneumocystis carinii in a foal.
Abstract: Subacute interstitial pneumonia with diffuse alveolar damage, marked macrophage infiltration, and intracellular Pneumocystis carinii cysts is described in a 3-month-old Swiss warmblood foal. Clinically, the disease was characterized by sudden onset of respiratory distress with fatal outcome. Based on serum immunoglobulin G (IgG), IgA, and IgM values, no humoral immunosuppression was detected. Spleen, thymus, and bronchial lymph nodes did not reveal lymphoid depletion, as assessed by immunohistochemical staining of CD-3-positive cells. Immunopathogenesis of pulmonary infections with intracellular agents in foals is discussed.
Publication Date: 1999-11-24 PubMed ID: 10568448DOI: 10.1354/vp.36-6-621Google Scholar: Lookup
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Summary
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This research article discusses a case of interstitial pneumonia in a 3-month-old foal, caused by Pneumocystis carinii, an infection that led to fatal respiratory distress. No immunosuppression was found in the foal’s system, and immunohistochemical staining did not show any depletion of lymphoid in the spleen, thymus, and bronchial lymph nodes.
Case of Interstitial Pneumonia
- The research talks about a case of interstitial pneumonia, a form of lung disease characterized by inflammation and scarring of the lungs, in a 3-month-old Swiss warmblood foal.
- This form of pneumonia was associated with Pneumocystis carinii, a type of fungus that causes lung infections. It led to diffuse alveolar damage and a high level of macrophage infiltration (cells that engulf and digest cellular debris, foreign substances, microbes).
- The disease was clinically observed as a sudden onset of respiratory distress leading to a fatal outcome for the young horse.
Examination of Immunosuppression and Lymphoid Depletion
- The researchers checked the foal’s immunoglobulin G (IgG), IgA, and IgM values to identify if there was any humoral immunosuppression. Humoral immunosuppression would refer to a decreased ability of the body to produce antibodies for immune response. However, in this case, no such immunosuppression was detected.
- The spleen, thymus, and bronchial lymph nodes of the horse were also examined to identify any lymphoid depletion. Lymphoid depletion would refer to a loss of lymphocytes, a type of white blood cell essential for the immune system. However, immunohistochemical staining of CD-3-positive cells did not show any signs of lymphoid depletion.
Discussion on Immunopathogenesis
- The research further discusses the immunopathogenesis of pulmonary infections with intracellular agents in foals. Immunopathogenesis refers to the process of disease development involving the immune system, in this case, specifically focusing on how lung infections develop in the presence of agents within the cells.
Cite This Article
APA
Perron Lepage MF, Gerber V, Suter MM.
(1999).
A case of interstitial pneumonia associated with Pneumocystis carinii in a foal.
Vet Pathol, 36(6), 621-624.
https://doi.org/10.1354/vp.36-6-621 Publication
Researcher Affiliations
- Département Hippique, Ecole Nationale Vétérinaire de Lyon, Marcy l'Etoile, France.
MeSH Terms
- Adrenal Cortex Hormones / therapeutic use
- Animals
- Anti-Bacterial Agents / therapeutic use
- Fatal Outcome
- Female
- Horse Diseases / microbiology
- Horse Diseases / pathology
- Horses
- Immunoglobulins / blood
- Immunohistochemistry
- Lung / pathology
- Lung Diseases, Interstitial / drug therapy
- Lung Diseases, Interstitial / pathology
- Lung Diseases, Interstitial / veterinary
- Lymph Nodes / immunology
- Pneumocystis / drug effects
- Pneumocystis / pathogenicity
- Pneumonia, Pneumocystis / drug therapy
- Pneumonia, Pneumocystis / pathology
- Pneumonia, Pneumocystis / veterinary
- Spleen / immunology
- Thymus Gland / immunology
Citations
This article has been cited 4 times.- Weissenbacher-Lang C, Blasi B, Bauer P, Binanti D, Bittermann K, Ergin L, Högler C, Högler T, Klier M, Matt J, Nedorost N, Silvestri S, Stixenberger D, Ma L, Cissé OH, Kovacs JA, Desvars-Larrive A, Posautz A, Weissenböck H. Detection of Pneumocystis and Morphological Description of Fungal Distribution and Severity of Infection in Thirty-Six Mammal Species. J Fungi (Basel) 2023 Feb 7;9(2).
- Moore I, Horney B, Day K, Lofstedt J, Cribb AE. Treatment of inflammatory airway disease in young standardbreds with interferon alpha. Can Vet J 2004 Jul;45(7):594-601.
- Balakrishnan A, Silverstein DC, Bedenice D, Bersenas A, Bourgeois JP, Carroll CL, Dunkel B, Greensmith T, Hopper K, Lascola K, Mangalmurti N, Rozanski E, Wilkins P, Yehya N. Acute Respiratory Distress Syndrome in Veterinary Medicine-The ARDSVet Definitions. J Vet Emerg Crit Care (San Antonio) 2025 Jul-Aug;35(4):327-338.
- Weissenbacher-Lang C, Grenl A, Blasi B. Meta-Analysis and Systematic Literature Review of the Genus Pneumocystis in Pet, Farm, Zoo, and Wild Mammal Species. J Fungi (Basel) 2023 Nov 4;9(11).
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