A cluster of equine granulomatous enteritis cases: the link with aluminium.
- Case Reports
- Journal Article
Summary
This research article explores a cluster of six cases of equine granulomatous enteritis, where aluminium was found in the damaged tissues and intestinal vessels, suggesting a possible link between the disease and aluminium exposure.
Research Summary
The research study described in the article focuses on a group of six cases of a condition called equine granulomatous enteritis, a disease characterized by chronic inflammation of the horse’s intestine. It is posited that the presence of aluminium may be associated with the occurrence of this disease and the study investigates this possible link.
Identification of Aluminium
- During the examination, a significant amount of aluminium was identified in the damaged tissues and intestinal vessels of the horses affected by granulomatous enteritis.
- The presence of aluminium in these specific areas suggests a potential link between the disease and aluminium exposure.
Investigation of Relationships
- The paper further discusses the relationship among granulomatous lesions, aluminium, acidity, and invading microorganisms.
- The researchers hypothesize that these factors might interact and result in the development of the disease.
- Particularly, the role of parasites in the disease progression was examined, as they are known to be associated with the onset of granulomatous enteritis in horses.
Detailed Discussion
After presenting the evidence and relationships mentioned above, the article proceeds with a detailed discussion of:
- The role of aluminium in the development of the disease.
- The underlying mechanisms by which acidity and the presence of microorganisms, particularly parasites, might contribute to the disease process.
The paper does not conclusively assert that aluminium is the cause of equine granulomatous enteritis, but presents it as a possible factor worth further investigation. The researchers affirm the need for more comprehensive studies to understand the complexity of the causes underlying this disease.
Cite This Article
Publication
Researcher Affiliations
- Irish Equine Centre, Johnstown, Naas, Co Kildare, Ireland.
MeSH Terms
- Aluminum / pharmacokinetics
- Aluminum / toxicity
- Animals
- Bone and Bones / metabolism
- Crohn Disease / chemically induced
- Crohn Disease / pathology
- Crohn Disease / veterinary
- Female
- Horse Diseases / chemically induced
- Horse Diseases / pathology
- Horses
- Kidney / metabolism
- Liver / metabolism
- Male
- Spectrophotometry, Atomic
Citations
This article has been cited 2 times.- Igbokwe IO, Igwenagu E, Igbokwe NA. Aluminium toxicosis: a review of toxic actions and effects. Interdiscip Toxicol 2019 Oct;12(2):45-70.
- Pineton de Chambrun G, Body-Malapel M, Frey-Wagner I, Djouina M, Deknuydt F, Atrott K, Esquerre N, Altare F, Neut C, Arrieta MC, Kanneganti TD, Rogler G, Colombel JF, Cortot A, Desreumaux P, Vignal C. Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice. Mucosal Immunol 2014 May;7(3):589-601.