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Home / Equine Research Bank / Front Vet Sci / A Comparative Review of Equine SIRS, Sepsis, and Neutrophils...
Frontiers in veterinary science2019; 6; 69; doi: 10.3389/fvets.2019.00069

A Comparative Review of Equine SIRS, Sepsis, and Neutrophils.

Abstract: The most recent definition of sepsis in human medicine can be summarized as organ dysfunction caused by a dysregulated host response to infection. In equine medicine, although no consensus definition is available, sepsis is commonly described as a dysregulated host systemic inflammatory response to infection. Defense against host infection is the primary role of innate immune cells known as neutrophils. Neutrophils also contribute to host injury during sepsis, making them important potential targets for sepsis prevention, diagnosis, and treatment. This review will present both historical and updated perspectives on the systemic inflammatory response (SIRS) and sepsis; it will also discuss the impact of sepsis on neutrophils, and the impact of neutrophils during sepsis. Future identification of clinically relevant sepsis diagnosis and therapy depends on a more thorough understanding of disease pathogenesis across species. To gain this understanding, there is a critical need for research that utilizes a clearly defined, and consistently applied, classification system for patients diagnosed with, and at risk of developing, sepsis.
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Publication Date: 2019-03-12 PubMed ID: 30931316PubMed Central: PMC6424004DOI: 10.3389/fvets.2019.00069Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article focuses on understanding the role of neutrophils, a type of immune cell, in the pathogenesis of sepsis in horses. The authors highlight the necessity for further research using a consistent classification system to identify potential diagnoses and treatments for sepsis.

Understanding Sepsis and SIRS

  • Sepsis is defined in human medicine as organ dysfunction caused by a dysregulated host response to infection. In equines, while there is no consensus definition, it is generally referred to as a systemic inflammatory response to infection that the host’s body can’t control.
  • The systemic inflammatory response (SIRS) refers to a widespread inflammatory reaction in the body as it attempts to fight off infection.
  • Clarification of these terms and a systematic approach to diagnosis is crucial since misclassification could lead to inappropriate treatment strategies.

Role of Neutrophils in Sepsis

  • Neutrophils are cells that form an integral part of the body’s innate immune system and are vital in defending against infection.
  • However, in conditions like sepsis, they can contribute to host injury, indicating their importance as potential targets in the prevention, diagnosis, and treatment of sepsis.

Need for Research and Consistent Classification System

  • There is a significant need for research targeting a more thorough understanding of disease pathogenesis across species; such knowledge is fundamental for the identification of clinically relevant sepsis diagnosis and therapy.
  • For such research to be effective, it should utilize a clearly defined, consistently applied classification system for patients diagnosed with, and at risk of, sepsis. This will help establish standard protocols for the diagnosis and treatment of sepsis across different species.

Cite This Article

APA
Sheats MK. (2019). A Comparative Review of Equine SIRS, Sepsis, and Neutrophils. Front Vet Sci, 6, 69. https://doi.org/10.3389/fvets.2019.00069

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 6
Pages: 69

Researcher Affiliations

Sheats, M Katie
  • Department of Clinical Sciences, North Carolina State University College of Veterinary Medicine, Raleigh, NC, United States.

Grant Funding

  • K01 OD015136 / NIH HHS

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