A comparative study of different tissue materials for bioprosthetic aortic valves using experimental assays and finite element analysis.
Abstract: Extracting the mechanical behaviors of bioprosthetic aortic valve leaflets is necessary for the appropriate design and manufacture of the prosthetic valves. The goal of this study was to opt a proper tissue for the valve leaflets by comparing the mechanical properties of the equine, porcine, and donkey pericardia with those of the bovine pericardium and human aortic valve leaflets. Methods: After tissue fixation in glutaraldehyde, the mechanical behaviors of the pericardial tissues were experimentally evaluated through computational methods. The relaxation tests were performed along the tissue fiber direction. The Mooney-Rivlin model was utilized to describe the hyperelastic behavior of the tissues at the ramp portion. The viscous behaviors at the hold portion were extracted using the Fung quasi-linear viscoelastic (QLV) model. Furthermore, the extracted parameters were used in the modeling of the bovine, equine, porcine, and donkey pericardia through finite element analysis (FEA). Results: Based on the results, relaxation percentages of the equine, donkey, and bovine pericardia were greater than that of the porcine pericardium and similar to the native human aortic valve leaflets. Indeed, the equine and donkey pericardia were found more viscous and less elastic than the porcine pericardium. Compared with the porcine pericardium, the mechanical properties of the equine and donkey pericardia were rather closer to those of the native human leaflets and bovine pericardium. The computational analysis demonstrated that the donkey pericardium is preferable over other types of pericardium due to the low stress on the leaflets during the systolic and diastolic phases and the large geometric orifice area (GOA). Conclusions: The donkey pericardium might be a good candidate valve leaflet material for bioprosthetic aortic valves.
Copyright © 2022 Elsevier B.V. All rights reserved.
Publication Date: 2022-04-12 PubMed ID: 35461127DOI: 10.1016/j.cmpb.2022.106813Google Scholar: Lookup
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Summary
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This research assessed various tissue materials for bioprosthetic aortic valves. It found that the donkey pericardium may be the best choice due to its mechanical properties and stress tolerance.
Objective of the Study
- The research aimed to find the best tissue material for bioprosthetic aortic valve leaflets by examining its mechanical properties. It compared the properties of equine, porcine, and donkey pericardia with bovine pericardium and human aortic valve leaflets.
Methodology
- The mechanical behaviors of these tissues were evaluated after fixation in glutaraldehyde using computational techniques.
- Tissue fiber direction was determined through relaxation tests.
- The Mooney-Rivlin model was used to describe the hyperelastic behavior of the tissues, while the Fung quasi-linear viscoelastic (QLV) model helped to extract the viscous behaviors.
- The parameters derived from these models were used in the finite element analysis (FEA) modeling of the different pericardia.
Results
- The study found that the equine, donkey, and bovine pericardium had more relaxation percentages than the porcine pericardium and were similar to the native human aortic valve leaflets.
- In terms of viscosity and elasticity, equine and donkey pericardia were more viscous and less elastic than the porcine pericardium.
- The mechanical properties of equine and donkey pericardia were closer to those of native human leaflets and bovine pericardium than the porcine pericardium.
- Computational analysis showed that donkey pericardium was preferred as it had low stress on leaflets during systolic and diastolic phases and a large geometric orifice area (GOA).
Conclusion
- The study concluded that donkey pericardium could potentially be an ideal material for bioprosthetic aortic valve leaflets due to its favorable mechanical properties and high stress tolerance during different phases of heart function.
Cite This Article
APA
Rassoli A, Fatouraee N, Guidoin R, Zhang Z, Ravaghi S.
(2022).
A comparative study of different tissue materials for bioprosthetic aortic valves using experimental assays and finite element analysis.
Comput Methods Programs Biomed, 220, 106813.
https://doi.org/10.1016/j.cmpb.2022.106813 Publication
Researcher Affiliations
- Department of Mechanical Engineering, K.N. Toosi University of Technology, Tehran, Iran; Department of Surgery, Faculty of Medicine, Université Laval and Centre de Recherche du CHU, Q, Canada.
- Biological Fluid Mechanics Research Laboratory, Biomedical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), P.O. Box: 15875-3413, Tehran, Iran. Electronic address: nasser@aut.ac.ir.
- Department of Surgery, Faculty of Medicine, Université Laval and Centre de Recherche du CHU, Q, Canada.
- Department of Surgery, Faculty of Medicine, Université Laval and Centre de Recherche du CHU, Q, Canada.
- Mechanical Engineering Faculty, Amirkabir University of Technology (Tehran Polytechnic), Tehran, Iran.
MeSH Terms
- Animals
- Aortic Valve / surgery
- Biomechanical Phenomena
- Bioprosthesis
- Cattle
- Elasticity
- Finite Element Analysis
- Heart Valve Prosthesis
- Horses
- Pericardium
- Swine
Conflict of Interest Statement
Declaration of Competing Interest The authors declare no conflicts of interest.
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