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Home / Equine Research Bank / Br J Nutr / A comparative study of free oligosaccharides in the milk of ...
The British journal of nutrition2014; 111(7); 1313-1328; doi: 10.1017/S0007114513003772

A comparative study of free oligosaccharides in the milk of domestic animals.

Abstract: The present study was conducted to obtain a comprehensive overview of oligosaccharides present in the milk of a variety of important domestic animals including cows, goats, sheep, pigs, horses and dromedary camels. Using an analytical workflow that included ultra-performance liquid chromatography-hydrophilic interaction liquid chromatography with fluorescence detection coupled to quadrupole time-of-flight MS, detailed oligosaccharide libraries were established. The partial or full characterisation of the neutral/fucosylated, phosphorylated and sialylated structures was facilitated by sequencing with linkage- and sugar-specific exoglycosidases. Relative peak quantification of the 2-aminobenzamide-labelled oligosaccharides provided additional information. Milk from domestic animals contained a much larger variety of complex oligosaccharides than was previously assumed, and thirteen of these structures have been identified previously in human milk. The direct comparison of the oligosaccharide mixtures reflects their role in the postnatal maturation of different types of gastrointestinal systems, which, in this way, are prepared for certain post-weaning diets. The potential value of animal milk for the commercial extraction of oligosaccharides to be used in human and animal health is highlighted.
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Publication Date: 2014-03-19 PubMed ID: 24635885DOI: 10.1017/S0007114513003772Google Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study presents an in-depth comparison of the oligosaccharide content in the milk of several domestic animals, furnishing detailed oligosaccharide libraries and pointing towards their importance in the development of distinct gastrointestinal systems and their potential commercial use.

Methodology

  • The study conducted a detailed analysis of oligosaccharides in the milk of various domestic animals such as cows, goats, sheep, pigs, horses, and dromedary camels.
  • The analysis employed a specially devised workflow involving ultra-performance liquid chromatography-hydrophilic interaction liquid chromatography. This was complemented with fluorescence detection linked to a quadrupole time-of-flight mass spectrometry method.
  • The acquired data were meticulously sequenced with the use of linkage- and sugar-specific exoglycosidases. This aided in the partial or complete characterization of the neutral/fucosylated, phosphorylated, and sialylated structures.
  • Additional information was obtained through the relative peak quantification of the 2-aminobenzamide-labelled oligosaccharides.

Findings

  • The study found a greater variety of complex oligosaccharides in the milk of domestic animals than was previously assumed. Thirteen of these structures had been previously identified in human milk.
  • By comparing the oligosaccharide mixtures, the study identified their role in the postnatal development of different types of gastrointestinal systems in animals.
  • It was observed that these systems are prepared for specific post-weaning diets, supported by the variety and specific types of oligosaccharides present in the respective animal milk.

Implications

  • The research provided an extensive overview of the oligosaccharides in domestic animal milk, enhancing the existing understanding of their variety and functionality.
  • The researchers highlighted the potential value of animal milk for the commercial extraction of oligosaccharides, which could then be used in human and animal health sectors.
  • This could allow greater benefits in nutritional supplementation and potentially new product development in both human and animal health industries.

Cite This Article

APA
Albrecht S, Lane JA, Mariño K, Al Busadah KA, Carrington SD, Hickey RM, Rudd PM. (2014). A comparative study of free oligosaccharides in the milk of domestic animals. Br J Nutr, 111(7), 1313-1328. https://doi.org/10.1017/S0007114513003772

Publication

The British journal of nutrition
ISSN: 1475-2662
NlmUniqueID: 0372547
Country: England
Language: English
Volume: 111
Issue: 7
Pages: 1313-1328

Researcher Affiliations

Albrecht, Simone
  • NIBRT GlycoScience Group, National Institute for Bioprocessing, Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Republic of Ireland.
Lane, Jonathan A
  • Teagasc Food Research Centre, Moorepark, Fermoy, County Cork, Republic of Ireland.
Mariño, Karina
  • NIBRT GlycoScience Group, National Institute for Bioprocessing, Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Republic of Ireland.
Al Busadah, Khalid A
  • Camel Research Center, King Faisal University, Al Ahsa, Saudi Arabia.
Carrington, Stephen D
  • Veterinary Sciences Centre, University College Dublin, Belfield, Dublin 4, Republic of Ireland.
Hickey, Rita M
  • Teagasc Food Research Centre, Moorepark, Fermoy, County Cork, Republic of Ireland.
Rudd, Pauline M
  • NIBRT GlycoScience Group, National Institute for Bioprocessing, Research and Training, Fosters Avenue, Mount Merrion, Blackrock, Dublin 4, Republic of Ireland.

MeSH Terms

  • Alkaline Phosphatase / metabolism
  • Animals
  • Animals, Inbred Strains
  • Bacterial Proteins / metabolism
  • Camelus
  • Cattle
  • Colostrum / chemistry
  • Female
  • Glycoside Hydrolases / metabolism
  • Goats
  • Horses
  • Ireland
  • Milk / chemistry
  • Molecular Structure
  • Oligosaccharides / analysis
  • Oligosaccharides / chemistry
  • Oligosaccharides / metabolism
  • Phosphorylation
  • Saudi Arabia
  • Sheep, Domestic
  • Sus scrofa
  • Tandem Mass Spectrometry

Citations

This article has been cited 65 times.
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