A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy.
Abstract: To compare the analgesic efficacy of buprenorphine plus detomidine with that of morphine plus detomidine when administered epidurally in horses undergoing bilateral stifle arthroscopy. Methods: Prospective, randomized, blinded clinical trial. Methods: Twelve healthy adult horses participating in an orthopedic research study. Group M (n = 6) received morphine (0.2 mg kg(-1)) and detomidine (0.15 mg kg(-1)) epidurally; group B (n = 6) received buprenorphine (0.005 mg kg(-1)) and detomidine (0.15 mg kg(-1)) epidurally. Methods: Horses received one of two epidural treatments following induction of general anesthesia for bilateral stifle arthroscopy. Heart rate (HR), mean arterial blood pressure (MAP), end-tidal CO(2) (Pe'CO(2)), and end-tidal isoflurane concentrations (E'Iso%) were recorded every 15 minutes following epidural administration. Post-operative assessment was performed at 1, 2, 3, 6, 9, 12, and 24 hours after standing; variables recorded included HR, respiratory rate (f(R)), abdominal borborygmi, defecation, and the presence of undesirable side effects. At the same times post-operatively, each horse was videotaped at a walk and subsequently assigned a lameness score (0-4) by three ACVS diplomates blinded to treatment and who followed previously published guidelines. Nonparametric data were analyzed using Wilcoxon's rank-sum test. Inter- and intra-rater agreement were determined using weighted kappa coefficients. Statistical significance was set at p <or= 0.05. Results: No statistically significant differences were found between groups with respect to intra-operative HR, MAP, E'Iso%, or post-operative HR, gastrointestinal function and cumulative median lameness scores. Post-operative f(R) in group B [24 (12-30), median (range)] breaths per minute was significantly higher than in group M [18 (15-20)] breaths per minute, p = 0.04. Conclusions: In horses undergoing bilateral stifle arthroscopy, these doses of buprenorphine plus detomidine injected epidurally produced analgesia similar in intensity and duration to that of morphine plus detomidine injected epidurally.
Publication Date: 2009-01-06 PubMed ID: 19121161DOI: 10.1111/j.1467-2995.2008.00422.xGoogle Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This study compares the effectiveness of two different combinations of painkillers administered via the spine in horses undergoing knee surgery. The main finding is that the effects of the two combinations are largely equivalent, although one of them led to a significantly increased breathing rate after surgery.
Design and Methodology
- This research was executed as a prospective, randomized, blinded clinical trial, meaning that the horses were randomly assigned to two different treatment groups, and the evaluators determining the effects of the treatments were not aware of which treatment each horse had received.
- The sample size included twelve adult horses who were part of an orthopedic research study. The horses were divided into two groups. Group M, consisted of six horses, received morphine and detomidine, while Group B also consisted of six horses, received buprenorphine and detomidine.
- The effectiveness of the treatment was assessed by monitoring heart rate, blood pressure, end-tidal CO(2), and end-tidal isoflurane concentrations. Additionally, post-operative assessments included monitoring of heart rate, respiratory rate, abdominal borborygmi (gut sounds), defecation, and any undesirable side effects. Moreover, horses’ movements were also videotaped and assessed for lameness by three veterinary surgery specialists who were unaware of the treatment each horse received.
Results
- The results showed no significant statistical differences between the two treatment groups in terms of heart rate, blood pressure, end-tidal isoflurane concentrations, or post-operative heart rate, gut function, and median lameness scores.
- However, there was a notable difference in the post-operative respiratory rate between the groups. Horses in group B, who were administered buprenorphine plus detomidine, showed a significantly higher respiratory rate compared to those in Group M.
Conclusions
- Overall, the study concluded that in horses undergoing bilateral stifle arthroscopy (knee surgery), epidural injections of buprenorphine plus detomidine and morphine plus detomidine had similar analgesic (pain relief) effects. However, the use of buprenorphine plus detomidine resulted in an elevated respiratory rate in the post-operative phase.
Cite This Article
APA
Fischer BL, Ludders JW, Asakawa M, Fortier LA, Fubini SL, Nixon AJ, Radcliffe RM, Erb HN.
(2009).
A comparison of epidural buprenorphine plus detomidine with morphine plus detomidine in horses undergoing bilateral stifle arthroscopy.
Vet Anaesth Analg, 36(1), 67-76.
https://doi.org/10.1111/j.1467-2995.2008.00422.x Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY, USA. bfischer@vetspecialty.com
MeSH Terms
- Analgesia, Epidural / veterinary
- Analgesics / administration & dosage
- Analgesics / pharmacology
- Analgesics, Opioid / administration & dosage
- Analgesics, Opioid / pharmacology
- Animals
- Buprenorphine / administration & dosage
- Buprenorphine / pharmacology
- Drug Therapy, Combination
- Female
- Horse Diseases / prevention & control
- Horses
- Imidazoles / administration & dosage
- Imidazoles / pharmacology
- Injections, Epidural
- Male
- Morphine / administration & dosage
- Morphine / pharmacology
- Pain / prevention & control
Citations
This article has been cited 3 times.- Gilbertie JM, Schaer TP, Engiles JB, Seiler GS, Deddens BL, Schubert AG, Jacob ME, Stefanovski D, Ruthel G, Hickok NJ, Stowe DM, Frink A, Schnabel LV. A Platelet-Rich Plasma-Derived Biologic Clears Staphylococcus aureus Biofilms While Mitigating Cartilage Degeneration and Joint Inflammation in a Clinically Relevant Large Animal Infectious Arthritis Model.. Front Cell Infect Microbiol 2022;12:895022.
- Hurtig MB, Buschmann MD, Fortier LA, Hoemann CD, Hunziker EB, Jurvelin JS, Mainil-Varlet P, McIlwraith CW, Sah RL, Whiteside RA. Preclinical Studies for Cartilage Repair: Recommendations from the International Cartilage Repair Society.. Cartilage 2011 Apr;2(2):137-52.
- Freitas GC, Carregaro AB, Gehrcke MI, De La Côrte FD, Lara VM, Pozzobon R, Brass KE. Epidural analgesia with morphine or buprenorphine in ponies with lipopolysaccharide (LPS)-induced carpal synovitis.. Can J Vet Res 2011 Apr;75(2):141-6.
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