A comparison of inulin, para-aminohippuric acid, and endogenous creatinine clearances as measures of renal function in neonatal foals.
Abstract: The glomerular filtration rate (GFR) was estimated in eight full-term neonatal foals by the single injection inulin plasma clearance method at two days of age, the continuous infusion plasma and urinary clearance methods at three days of age, and the 12-hour endogenous creatinine clearance method at four days of age. The effective renal plasma flow (ERPF) was estimated simultaneously by the single injection para-aminohippuric acid (PAH) plasma clearance method in the eight two-day old foals and the continuous PAH infusion plasma and urinary clearance method in the eight three-day old foals. The GFR (+/- 1 SEM), as determined from the single injection plasma clearance method, was 2.30 +/- 0.34 mL/kg/min; by continuous infusion plasma clearance 2.56 +/- 0.30 mL/kg/min; by continuous infusion urinary clearance 2.82 +/- 0.32 mL/kg/min; and by 12-hour endogenous creatinine clearance 2.81 +/- 0.55 mL/kg/min. Effective renal plasma flow (+/- 1 SEM) measured by the single injection plasma clearance method was 15.22 +/- 1.5 mL/kg/min, by continuous infusion plasma clearance was 18.21 +/- 2.0 mL/kg/min. and by continuous infusion urinary clearance it was 11.95 +/- 1.9 mL/kg/min. The results of these methods were not statistically different. On a per kilogram body weight basis, the full-term neonatal foal's GFR and ERPF was determined to be comparable with adult equine GFR and ERPF.
Publication Date: 1990-11-01 PubMed ID: 2074554DOI: 10.1111/j.1939-1676.1990.tb03127.xGoogle Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The study aimed to compare methods of estimating kidney function in newborn foals, determining that the results were similar across the different methods and comparable to adult horse kidney function measures.
Objective of the Study
- The research set out to compare different ways of estimating the glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) in full-term newborn foals.
- These measures are used to evaluate how well the kidneys are working. GFR refers to the rate at which the kidneys filter blood, while ERPF is the volume of plasma that the kidneys clear of a particular substance (in this case, para-aminohippuric acid, or PAH) in a given time.
- The research aimed to validate the use of various estimation methods in neonatal horses, a population where little prior information was available.
Methods Utilized
- The study utilized three main methods to estimate GFR: single injection inulin plasma clearance, continuous infusion plasma and urinary clearance, and 12-hour endogenous creatinine clearance.
- For measuring ERPF, the researchers used two methods: the single injection PAH plasma clearance method and the continuous PAH infusion plasma and urinary clearance method. These tests were conducted when the foals were between two to four days old.
Findings of the Study
- The study reports that the different methods gave similar results — that is, they were not statistically different. More specifically, the GFR values ranged from 2.30 to 2.81 mL/kg/min, and the ERPF values ranged from 11.95 to 18.21 mL/kg/min, depending on the test method used.
- The researchers also concluded that the GFR and ERPF rates in neonatal foals were comparable to those in adult horses. The kidney function of newborn foals was found to be roughly equal to that of adult horses when adjusted for body weight.
Significance of the Study
- The study’s results validated the use of these estimation methods in assessing renal function in neonatal horses, and provided normative values for comparison in future studies or for clinical use.
- The research also found that kidney filtration rates and plasma flow were similar across different age groups within the horse population.
Cite This Article
APA
Brewer BD, Clement SF, Lotz WS, Gronwall R.
(1990).
A comparison of inulin, para-aminohippuric acid, and endogenous creatinine clearances as measures of renal function in neonatal foals.
J Vet Intern Med, 4(6), 301-305.
https://doi.org/10.1111/j.1939-1676.1990.tb03127.x Publication
Researcher Affiliations
- Department of Medical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136.
MeSH Terms
- Animals
- Animals, Newborn / physiology
- Creatinine / urine
- Female
- Glomerular Filtration Rate / veterinary
- Horses / physiology
- Infusions, Intravenous
- Injections, Intravenous / veterinary
- Inulin / administration & dosage
- Kidney / physiology
- Male
- Reference Values
- p-Aminohippuric Acid / administration & dosage
Citations
This article has been cited 2 times.- Galvin N, Collins D. Perinatal asphyxia syndrome in the foal: review and a case report. Ir Vet J 2004 Dec 1;57(12):707-14.
- van Galen G, Divers TJ, Savage V, Schott HC 2nd, Siwinska N. ECEIM consensus statement on equine kidney disease. J Vet Intern Med 2024 Jul-Aug;38(4):2008-2025.
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