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BMC genetics2018; 19(1); 80; doi: 10.1186/s12863-018-0670-3

A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism.

Abstract: Although harness racing is of high economic importance to the global equine industry, significant genomic resources have yet to be applied to mapping harness racing success. To identify genomic regions associated with harness racing success, the current study performs genome-wide association analyses with three racing performance traits in the Norwegian-Swedish Coldblooded Trotter using the 670 K Axiom Equine Genotyping Array. Following quality control, 613 horses and 359,635 SNPs were retained for further analysis. After strict Bonferroni correction, nine genome-wide significant SNPs were identified for career earnings. No genome-wide significant SNPs were identified for number of gallops or best km time. However, four suggestive genome-wide significant SNPs were identified for number of gallops, while 19 were identified for best km time. Multiple genes related to intelligence, energy metabolism, and immune function were identified as potential candidate genes for harness racing success. Apart from the physiological requirements needed for a harness racing horse to be successful, the results of the current study also advocate learning ability and memory as important elements for harness racing success. Further exploration into the mental capacity required for a horse to achieve racing success is likely warranted.
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Publication Date: 2018-08-29 PubMed ID: 30157760PubMed Central: PMC6114527DOI: 10.1186/s12863-018-0670-3Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses a genome-wide association study conducted on the Norwegian-Swedish Coldblooded Trotter breed of horses, designed to identify genes associated with harness racing success.

Research Methodology

  • The researchers used a method called a genome-wide association study, to examine for markers across complete DNA sets in a large population.
  • They focused on the Norwegian-Swedish Coldblooded Trotter breed and used the 670K Axiom Equine Genotyping array, a high-resolution genetic tool that allows comprehensive analysis of genes.
  • The study featured data from a total of 613 horses with 359,635 Single Nucleotide Polymorphisms (SNPs).

Results

  • Nine genome-wide significant SNPs were identified for career earnings and numerous for best kilometer time and the number of gallops.
  • No genome-wide significant SNPs were found for the number of gallops or the best kilometer time.
  • A close relationship was noted between these SNPs and genes associated with intelligence, energy metabolism, and immune function

Significance of the Results

  • The research found potential candidate genes that could be linked to harness racing success in this specific breed of horses.
  • It suggested that apart from the necessary physical attributes, the mental abilities of the horse such as learning ability and memory play a significant role in harness racing success.
  • The study provides a path for future investigations to explore the mental capacity, not just physical, required for a horse to achieve racing success.

Cite This Article

APA
Velie BD, Fegraeus KJ, Solé M, Rosengren MK, Røed KH, Ihler CF, Strand E, Lindgren G. (2018). A genome-wide association study for harness racing success in the Norwegian-Swedish coldblooded trotter reveals genes for learning and energy metabolism. BMC Genet, 19(1), 80. https://doi.org/10.1186/s12863-018-0670-3

Publication

BMC genetics
ISSN: 1471-2156
NlmUniqueID: 100966978
Country: England
Language: English
Volume: 19
Issue: 1
Pages: 80
PII: 80

Researcher Affiliations

Velie, Brandon D
  • Department of Animal Breeding & Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden. brandon.velie@slu.se.
Fegraeus, Kim Jäderkvist
  • Department of Animal Breeding & Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Solé, Marina
  • Department of Animal Breeding & Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Rosengren, Maria K
  • Department of Animal Breeding & Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Røed, Knut H
  • Department of Basic Sciences and Aquatic Medicine, Norwegian University of Life Sciences, Oslo, Norway.
Ihler, Carl-Fredrik
  • Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway.
Strand, Eric
  • Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, Oslo, Norway.
Lindgren, Gabriella
  • Department of Animal Breeding & Genetics, Swedish University of Agricultural Sciences, Uppsala, Sweden.
  • Department of Biosystems, KU Leuven, 3001, Leuven, Belgium.

MeSH Terms

  • Animals
  • Energy Metabolism / genetics
  • Female
  • Genome-Wide Association Study
  • Horses / genetics
  • Horses / metabolism
  • Horses / physiology
  • Horses / psychology
  • Learning
  • Male
  • Polymorphism, Single Nucleotide
  • Quantitative Trait, Heritable

Conflict of Interest Statement

ETHICS APPROVAL AND CONSENT TO PARTICIPATE: All experimental procedures and sample collection methods were approved by the Ethics Committee for Animal Experiments in Uppsala, Sweden [Number: C 121/14]. Samples used in the study were already available at either the Animal Genetics Laboratory at SLU in Uppsala, Sweden or the Department of Basic Sciences and Aquatic Medicine at the Norwegian University of Life Sciences in Oslo, Norway as they previously had been used for parentage testing. Permission to use the samples was granted from the Swedish Trotting Association and the Norwegian Trotting Association (the owners of the samples per the rules/guidelines of the industry). CONSENT FOR PUBLICATION: Not applicable. COMPETING INTERESTS: The authors have the following interest: GL is a co-inventor on a granted patent concerning commercial testing of the DMRT3 mutation: A method to predict the pattern of locomotion in horses. PCT EP 12747875.8. European patent registration date: 2011-05-05, US patent registration date: 2011-08-03. There are no further patents, products in development, or marketed products to declare. PUBLISHER’S NOTE: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

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