A new clinical approach: use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses.
Abstract: In this study, we present an innovative therapy using stem cells that were obtained from the peripheral blood of racehorses affected by uninduced superficial digital flexor tendon (SDFT) injuries. Methods: Blood-derived stem cells (BDSCs) were generated from the blood samples of three horses in the presence of macrophage colony-stimulating factor (M-CSF). The racehorses received a single autologous BDSC treatment, which resulted in the successful repair of the tendons injuries. Results: The results demonstrated that the BDSCs injection into the damaged tendon stimulated the regeneration of normal tissue. Furthermore, a relationship may exist between the speed and the quality of new tissue formation and the welfare and management of the treated animals. Conclusions: This study demonstrates that stem cell technology offers new tools for tissue repair that in many cases is considered incurable, and provides additional evidence that BDScs injections increase the speed and quality of the regeneration process in different animal tissues.
Copyright © 2012 Elsevier Inc. All rights reserved.
Publication Date: 2012-03-28 PubMed ID: 22480518DOI: 10.1016/j.lfs.2012.03.004Google Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The study focuses on an innovative therapy for treating superficial digital flexor tendon (SDFT) injuries in racehorses using blood-derived stem cells (BDSCs). The results showed that injecting BDSCs in the injured tendon aids in the regeneration of normal tissue.
Methodology
- The researchers derived BDSCs from peripheral blood samples of three horses suffering from uninduced SDFT injuries.
- The generation of BDSCs was facilitated by the presence of macrophage colony-stimulating factor (M-CSF), a substance that stimulates the production of macrophages, a type of white blood cell.
- The injured racehorses received a single treatment of autologous BDSCs. Autologous refers to the fact that the stem cells were derived from the horse’s own body, which eliminates the risk of an immune response against the treatment.
Results
- The results of this therapy were positive, as the injection of BDSCs into the injured tendon led to the successful repair of the tendon injuries.
- The study also suggests that the application of these stem cells stimulated the regeneration of normal tendon tissue in the treated horses.
- The researchers noticed an interesting potential correlation between the speed and quality of new tissue formation and the welfare and treatment of the treated horses, suggesting that proper animal care is a crucial factor for the success of this therapy.
Conclusions
- The study concludes that stem cell technology presents significant potential for the treatment of injuries previously considered incurable.
- Specifically, the study provides evidence that BDSCs injections can enhance the speed and quality of the regeneration process in different types of animal tissue.
- This is a significant development in both healthcare for racehorses and broader veterinary medicine.
Cite This Article
APA
Marfe G, Rotta G, De Martino L, Tafani M, Fiorito F, Di Stefano C, Polettini M, Ranalli M, Russo MA, Gambacurta A.
(2012).
A new clinical approach: use of blood-derived stem cells (BDSCs) for superficial digital flexor tendon injuries in horses.
Life Sci, 90(21-22), 825-830.
https://doi.org/10.1016/j.lfs.2012.03.004 Publication
Researcher Affiliations
- Department of Experimental Medicine and Sciences, University of Roma Tor Vergata, Italy.
MeSH Terms
- Animals
- Female
- Horse Diseases / pathology
- Horse Diseases / therapy
- Horses / injuries
- Macrophage Colony-Stimulating Factor / pharmacology
- Male
- Regeneration
- Stem Cell Transplantation / methods
- Stem Cell Transplantation / veterinary
- Tendon Injuries / therapy
- Tendon Injuries / veterinary
- Time Factors
- Treatment Outcome
Citations
This article has been cited 10 times.- Roberts JH, Halper J. Growth Factor Roles in Soft Tissue Physiology and Pathophysiology. Adv Exp Med Biol 2021;1348:139-159.
- Ribitsch I, Baptista PM, Lange-Consiglio A, Melotti L, Patruno M, Jenner F, Schnabl-Feichter E, Dutton LC, Connolly DJ, van Steenbeek FG, Dudhia J, Penning LC. Large Animal Models in Regenerative Medicine and Tissue Engineering: To Do or Not to Do. Front Bioeng Biotechnol 2020;8:972.
- Gambacurta A, Merlini G, Ruggiero C, Diedenhofen G, Battista N, Bari M, Balsamo M, Piccirillo S, Valentini G, Mascetti G, Maccarrone M. Human osteogenic differentiation in Space: proteomic and epigenetic clues to better understand osteoporosis. Sci Rep 2019 Jun 6;9(1):8343.
- Barboni B, Russo V, Berardinelli P, Mauro A, Valbonetti L, Sanyal H, Canciello A, Greco L, Muttini A, Gatta V, Stuppia L, Mattioli M. Placental Stem Cells from Domestic Animals: Translational Potential and Clinical Relevance. Cell Transplant 2018 Jan;27(1):93-116.
- Arianna C, Eliana C, Flavio A, Marco R, Giacomo D, Manuel S, Elena B, Alessandra G. Rapid Rapamycin-Only Induced Osteogenic Differentiation of Blood-Derived Stem Cells and Their Adhesion to Natural and Artificial Scaffolds. Stem Cells Int 2017;2017:2976541.
- Wang JH, Nirmala X. Application of Tendon Stem/Progenitor Cells and Platelet-Rich Plasma to Treat Tendon Injuries. Oper Tech Orthop 2016 Jun;26(2):68-72.
- Carpentieri A, Cozzoli E, Scimeca M, Bonanno E, Sardanelli AM, Gambacurta A. Differentiation of human neuroblastoma cells toward the osteogenic lineage by mTOR inhibitor. Cell Death Dis 2015 Nov 12;6(11):e1974.
- Carvalho Ade M, Badial PR, Álvarez LE, Yamada AL, Borges AS, Deffune E, Hussni CA, Garcia Alves AL. Equine tendonitis therapy using mesenchymal stem cells and platelet concentrates: a randomized controlled trial. Stem Cell Res Ther 2013 Jul 22;4(4):85.
- Filomeno P, Dayan V, Touriño C. Stem cell research and clinical development in tendon repair. Muscles Ligaments Tendons J 2012 Jul;2(3):204-11.
- Muttini A, Salini V, Valbonetti L, Abate M. Stem cell therapy of tendinopathies: suggestions from veterinary medicine. Muscles Ligaments Tendons J 2012 Jul;2(3):187-92.
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