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Home / Equine Research Bank / J Vet Intern Med / A novel placement method of a calibration-free pH capsule fo...
Journal of veterinary internal medicine2024; 39(1); e17273; doi: 10.1111/jvim.17273

A novel placement method of a calibration-free pH capsule for continuous wireless measurement of intragastric pH in horses.

Abstract: Current methods to measure intragastric pH in horses have limitations. A wireless capsule has been designed for continuous esophageal pH monitoring in humans. Objective: To (1) determine the feasibility and describe the methodology of measuring intragastric pH wirelessly in horses; and (2) determine attachment duration of the capsules. Methods: Eleven healthy adult horses. Methods: Capsules were attached to squamous and glandular gastric mucosa under gastroscopic guidance, using suture loops and 1 to 4 hemostasis clips. pH was continuously recorded using a wireless recorder in both fed and fasted states. Gastroscopy was performed daily to assess capsule attachment and any mucosal damage. Data were analyzed using commercially available software. Values are reported as median (interquartile range). Results: Capsules were successfully placed and data obtained in squamous (n = 11) and glandular (n = 7) regions. The overall duration of squamous capsule attachment was 27 hours (15-32); 1 clip (n = 4) was 15 hours (11-20), 2 clips (n = 2) was 20 hours (16-23), 3 clips (n = 4) was 32 hours (30-32), and 4 clips (n = 1) was 33 hours. The overall duration of glandular capsule attachment was 10 hours (8-21); 1 clip (n = 2) was 11 hours (10-13), 2 clips (n = 2) was 19 hours (14-23), 3 clips (n = 2) was 7 hours (7-8), and 4 clips (n = 1) was 158 hours. There was no substantial damage to the gastric mucosa as a consequence of attachment. Conclusions: This novel technique enables the wireless measurement of intragastric pH in horses at known locations under fed and fasted conditions, providing a viable alternative for continuous monitoring in both research and clinical scenarios.
© 2024 The Author(s). Journal of Veterinary Internal Medicine published by Wiley Periodicals LLC on behalf of American College of Veterinary Internal Medicine.
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Publication Date: 2024-12-23 PubMed ID: 39715411PubMed Central: PMC11665962DOI: 10.1111/jvim.17273Google Scholar: Lookup
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Summary

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The research paper discussed the development and implementation of a new technique for measuring intragastric pH in horses using a wireless capsule, offering a more efficient and data-rich alternative to existing methods.

Methodology

  • The study included eleven healthy adult horses. The researchers used a specially-designed wireless capsule, intended to be attached to the squamous and glandular gastric mucosa in horses.
  • The attachment was done using suture loops in conjunction with 1 to 4 hemostasis clips under gastroscopic guidance.
  • The capsule was then capable of recording the intragastric pH fairly continuously, with readings taken both while the horses were fed and while they were fasted.
  • Regular gastroscopy was performed on a daily basis to verify that the capsule remained attached and to verify that no mucosal damage had occurred as a result of the attachment.
  • Measurements and data were processed and analyzed using specialized software.

Results

  • The study found that the wireless capsules were effectively placed and data was successfully collected in both squamous (n = 11) and glandular (n = 7) gastric regions.
  • Capsules attached to the squamous region remained in place for a median time of 27 hours, whereas those in the glandular region stayed attached for a median duration of 10 hours.
  • Importantly, there was no notable damage to the gastric mucosa of the horses as a result of the capsule’s attachment.

Implications

  • This new method offers a gateway to monitor intragastric pH in horses without any need for calibration and in a manner which is less invasive and more efficient than traditional practices.
  • The capability to conduct continuous monitoring in both fed and fasted conditions provides a detailed and comprehensive understanding of intragastric pH fluctuations in horses.
  • This novel technique has wide applications in both research and clinical contexts, potentially improving the health management and wellbeing of horses.

Cite This Article

APA
Hodgson E, Thirouin M, Narayanan P, Romano TR, Wise J, Bond S. (2024). A novel placement method of a calibration-free pH capsule for continuous wireless measurement of intragastric pH in horses. J Vet Intern Med, 39(1), e17273. https://doi.org/10.1111/jvim.17273

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 39
Issue: 1
Pages: e17273
PII: e17273

Researcher Affiliations

Hodgson, Evelyn
  • School of Veterinary Science, Faculty of Science, University of Queensland, Gatton, Queensland 4343, Australia.
Thirouin, Marthe
  • School of Veterinary Science, Faculty of Science, University of Queensland, Gatton, Queensland 4343, Australia.
Narayanan, Pranav
  • School of Veterinary Science, Faculty of Science, University of Queensland, Gatton, Queensland 4343, Australia.
Romano, Tallia-Rume
  • School of Veterinary Science, Faculty of Science, University of Queensland, Gatton, Queensland 4343, Australia.
Wise, Jessica
  • School of Veterinary Science, Faculty of Science, University of Queensland, Gatton, Queensland 4343, Australia.
Bond, Stephanie
  • School of Veterinary Science, Faculty of Science, University of Queensland, Gatton, Queensland 4343, Australia.

MeSH Terms

  • Animals
  • Horses / physiology
  • Hydrogen-Ion Concentration
  • Male
  • Female
  • Wireless Technology / instrumentation
  • Gastric Acidity Determination / veterinary
  • Gastric Acidity Determination / instrumentation
  • Gastroscopy / veterinary
  • Gastroscopy / instrumentation
  • Gastroscopy / methods
  • Stomach

Grant Funding

  • Building Industry Research Relationships in Science and Translation (BIRRST), The University of Queensland
  • Adam Gillespie Memorial Scholarship for Animal Husbandry

Conflict of Interest Statement

Authors declare no conflict of interest.

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