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Veterinary surgery : VS2014; 44(3); 359-365; doi: 10.1111/j.1532-950X.2014.12240.x

A preliminary study of silver sodium zirconium phosphate polyurethane foam wound dressing on wounds of the distal aspect of the forelimb in horses.

Abstract: To determine if application of silver sodium zirconium phosphate polyurethane semi-occlusive foam (SPF) dressing would improve measures of wound healing and decrease bacterial contamination compared with a non-adherent, absorbent dressing applied to wounds created on the distal aspect of the equine limb. Methods: Controlled randomized experimental study. Methods: Adult Quarter Horse and Thoroughbred horses (n = 5). Methods: One 6.25 cm(2) wound was created on the dorsomedial aspect of the proximal metacarpus on each forelimb. A SPF dressing was applied to 1 randomly assigned limb as a treatment and a non-adherent, absorbent dressing was applied to the opposite limb as control. Bandages were changed every 3 days for 60 days. Granulation tissue was scored every 3 days, wound area measured every 6 days, and wound bed was cultured every 12 days. Results: SPF-treatment wounds had significantly decreased wound area and decreased granulation tissue scores when evaluated <30 days and over the 60 day study, although complete wound healing times were not significantly different. Bacteria were cultured from all wounds at varying times throughout the study. Conclusions: The SPF wound dressing improved some measures of wound healing compared with the control dressing, most significantly during the first 30 days. This suggests that the SPF wound dressing may be useful in the early management of wounds on the equine lower limb. Further studies using the SPF dressing are needed to characterize the temporal and cellular effects on wound healing and evaluate this dressing in a clinical environment.
Publication Date: 2014-07-09 PubMed ID: 25040441DOI: 10.1111/j.1532-950X.2014.12240.xGoogle Scholar: Lookup
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  • Journal Article
  • Randomized Controlled Trial
  • Research Support
  • Non-U.S. Gov't

Summary

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The research article investigates whether the use of a wound dressing made from a material called silver sodium zirconium phosphate polyurethane foam improves healing in wounds on horse’s limbs, compared to a conventional absorbent dressing.

Study Methodology

This was a controlled and randomized experimental study involving five adult Quarter Horse and Thoroughbred horses. A wound of fixed size (6.25 cm2) was made on a specific part of each horse’s forelimb. One wound was treated with the special polyurethane foam dressing (termed SPF dressing), and the other with a standard non-adherent absorbent dressing. For both types, dressings were changed every three days over a period of 60 days.

  • Granulation tissue in the wounded area was examined and rated in terms of severity every three days.
  • The precise area of the wound was measured every six days.
  • A culture was taken from the wound bed every 12 days to assess bacterial contamination.

Outcomes

Throughout the first 30 days and over the complete 60-day trial, wounds that had been dressed with SPF showed a more significant decrease in size and granulation tissue scores than those treated with the standard dressing. Despite this, the times taken for complete healing to be achieved did not differ significantly between the SPF-treated wounds and the controls. Bacterial contamination was discovered in all wounds, regardless of treatment type, at various points over the course of the research.

Conclusions and Implications

The results indicate that the SPF dressing showed incremental improvements in a couple of wound healing factors as compared to the control dressing, particularly in the initial 30-day period. Therefore, the authors conclude that SPF dressing might be a useful tool in the early stages of treating wounds on a horse’s lower limb. Suggestions have been made for additional studies to further understand its effects on wound healing over time and at a cellular level and to assess its suitability in an actual clinical setting.

Cite This Article

APA
Kelleher ME, Kilcoyne I, Dechant JE, Hummer E, Kass PH, Snyder JR. (2014). A preliminary study of silver sodium zirconium phosphate polyurethane foam wound dressing on wounds of the distal aspect of the forelimb in horses. Vet Surg, 44(3), 359-365. https://doi.org/10.1111/j.1532-950X.2014.12240.x

Publication

ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 44
Issue: 3
Pages: 359-365

Researcher Affiliations

Kelleher, Maureen E
  • William R. Pritchard Veterinary Medical Teaching Hospital, University of California-Davis, Davis, California.
Kilcoyne, Isabelle
    Dechant, Julie E
      Hummer, Emma
        Kass, Philip H
          Snyder, Jack R

            MeSH Terms

            • Animals
            • Bandages / veterinary
            • Female
            • Forelimb / injuries
            • Horses / injuries
            • Male
            • Phosphates / administration & dosage
            • Polyurethanes / administration & dosage
            • Silver Compounds / administration & dosage
            • Surgical Wound Infection / microbiology
            • Surgical Wound Infection / pathology
            • Surgical Wound Infection / prevention & control
            • Surgical Wound Infection / veterinary
            • Treatment Outcome
            • Wound Healing
            • Zirconium / administration & dosage

            Citations

            This article has been cited 2 times.
            1. Ribeiro G, Carvalho L, Borges J, Prazeres J. The Best Protocol to Treat Equine Skin Wounds by Second Intention Healing: A Scoping Review of the Literature. Animals (Basel) 2024 May 18;14(10).
              doi: 10.3390/ani14101500pubmed: 38791717google scholar: lookup
            2. Helal IE, Al-Abbadi HA, El-Daharawy MH, Ahmed MF. Enhancement of chronic wound healing with maltodextrin/ascorbic acid gel: a clinical evaluation of distal limb wounds in horses. J Anim Sci Technol 2022 Sep;64(5):997-1007.
              doi: 10.5187/jast.2022.e52pubmed: 36287738google scholar: lookup