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Genome research1998; 8(9); 951-966; doi: 10.1101/gr.8.9.951

A primary male autosomal linkage map of the horse genome.

Abstract: A primary male autosomal linkage map of the domestic horse (Equus caballus) has been developed by segregation analysis of 140 genetic markers within eight half-sib families. The family material comprised four Standardbred trotters and four Icelandic horses, with a total of 263 offspring. The marker set included 121 microsatellite markers, eight protein polymorphisms, five RFLPs, three blood group polymorphisms, two PCR-RFLPs, and one single strand conformation polymorphism (SSCP). One hundred markers were arranged into 25 linkage groups, 22 of which could be assigned physically to 18 different chromosomes (ECA1, ECA2, ECA3, ECA4, ECA5, ECA6, ECA7, ECA9, ECA10, ECA11, ECA13, ECA15, ECA16, ECA18, ECA19, ECA21, ECA22, and ECA30). The average distance between linked markers was 12.6 cM and the longest linkage group measured 103 cM. The total map distance contained within linkage groups was 679 cM. If the distances covered outside the ends of linkage groups and by unlinked markers were included, it was estimated that the marker set covered at least 1500 cM, that is, at least 50% of the genome. A comparison of the relationship between genetic and physical distances in anchored linkage groups gave ratios of 0.5-0.8 cM per Mb of DNA. This would suggest that the total male recombinational distance in the horse is 2000 cM; this value is lower than that suggested by chiasma counts. The present map should provide an important framework for future genome mapping in the horse.
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Publication Date: 1998-09-29 PubMed ID: 9750194PubMed Central: PMC310772DOI: 10.1101/gr.8.9.951Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper discusses the development of a primary male autosomal linkage map of the domestic horse genome, which was achieved by analysing 140 genetic markers across eight horse families. The study provides a framework for future genome mapping in horses.

Development of the Male Autosomal Linkage Map

  • The study established a primary male autosomal linkage map of the domestic horse (Equus caballus) by conducting segregation analysis of 140 genetic markers within eight half-sib families.
  • The eight families comprised of four Standardbred trotters and four Icelandic horses, with a total of 263 offspring. These diverse breeds provided a comprehensive pool for the study.
  • The marker set included 121 microsatellite markers, eight protein polymorphisms, five Restriction Fragment Length Polymorphisms (RFLPs), three blood group polymorphisms, two Polymerase Chain Reaction-Restriction Fragment Length Polymorphisms (PCR-RFLPs), and one single strand conformation polymorphism (SSCP).
  • The study successfully arranged one hundred markers into 25 linkage groups with 22 of these groups physically assigned to 18 different chromosomes (such as ECA1, ECA2, ECA3 and so on up to ECA30).

Results and Assessments

  • The average distance between linked markers was measured at 12.6 centiMorgans (cM) and the longest linkage group measured 103 cM.
  • The total map distance contained within linkage groups was 679 cM. If the distances covered outside the ends of linkage groups and by unlinked markers were included, it was estimated that the marker set covered at least 1500 cM, which is at least 50% of the horse genome.

    • <liComparing the relationship between genetic and physical distances in anchored linkage groups gave ratios of 0.5-0.8 cM per mega base (Mb) of DNA.

  • This suggests that the total male recombinational distance in the horse is 2000 cM; a value lower than that suggested by chiasma counts.

Impact and Future Directions

  • The research provides a solid foundation for future studies focused on genome mapping in horses. The insight might improve understanding of horse genetics and stimulate further advancements.

Cite This Article

APA
Lindgren G, Sandberg K, Persson H, Marklund S, Breen M, Sandgren B, Carlstén J, Ellegren H. (1998). A primary male autosomal linkage map of the horse genome. Genome Res, 8(9), 951-966. https://doi.org/10.1101/gr.8.9.951

Publication

Genome research
ISSN: 1088-9051
NlmUniqueID: 9518021
Country: United States
Language: English
Volume: 8
Issue: 9
Pages: 951-966

Researcher Affiliations

Lindgren, G
  • Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, S-751 24 Uppsala, Sweden. Gabriella.Lindgren@bmc.uu.se
Sandberg, K
    Persson, H
      Marklund, S
        Breen, M
          Sandgren, B
            Carlstén, J
              Ellegren, H

                MeSH Terms

                • Animals
                • Blood Group Antigens
                • Chromosome Mapping
                • Genetic Linkage
                • Genetic Markers
                • Genome
                • Horses / blood
                • Horses / genetics
                • Male
                • Microsatellite Repeats
                • Polymerase Chain Reaction / methods
                • Polymorphism, Genetic
                • Polymorphism, Restriction Fragment Length
                • Polymorphism, Single-Stranded Conformational
                • Proteins / genetics

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