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Home / Equine Research Bank / Vet Res Commun / A reagin-like antibody in horse serum. II. Anti-human IgE in...
Veterinary research communications1983; 6(2); 111-122; doi: 10.1007/BF02214903

A reagin-like antibody in horse serum. II. Anti-human IgE induced reversed cutaneous anaphylaxis-like responses in horse skin.

Abstract: Fc specific anti-human IgE serum induced prolonged reversed cutaneous anaphylaxis (RCA)-like reactions in horse skin. Morphologically and histologically, these reactions resembled passively induced late cutaneous anaphylaxis responses in human skin, but differed from reversed passive Arthus responses induced in horse skin using anti-horse IgG serum. The induction of RCA-like responses in horse skin by anti-human IgE indicates shared Fc antigenic determinants on human IgE and a horse homocytotropic or reagin-like antibody.
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Publication Date: 1983-03-01 PubMed ID: 6603051DOI: 10.1007/BF02214903Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses a study on how anti-human IgE serum produces long-lasting reversed cutaneous anaphylaxis (RCA)-like reactions in horse skin, suggesting common antigenic determinants in human IgE and a horse antibody similar to reagin.

Methodology and Evaluation

  • The study involved the use of Fc specific anti-human IgE serum, which was injected directly into a horse’s skin. This produced a reversed cutaneous anaphylaxis (RCA)-like response.
  • These outcome were then compared both morphologically and histologically with passively induced late cutaneous anaphylaxis responses in human skin.
  • Separately, the reactions were compared against reversed passive Arthus responses which were induced in horse skin using anti-horse IgG serum.

Key Observations and Findings

  • The study observed RCA-like reactions in horse skin that closely resembled passively induced late cutaneous anaphylaxis responses seen in human skin.
  • However, it was also noted that the responses in the horse skin differed from the reactions produced when anti-horse IgG serum was used to induce reversed passive Arthus responses.

Significance and Implications

  • The reactions produced by the anti-human IgE serum in the horse skin indicate possibly shared Fc antigenic determinants on human IgE and a reagin-like antibody in horses.
  • This could imply a commonality between human and horse immune responses, potentially providing insights that could assist in managing allergic reactions in both species.
  • The findings could also prompt further investigation into the similarities and differences between human and animal antibodies, offering valuable information for the fields of veterinary and human medicine.

Cite This Article

APA
Matthews AG, Imlah P, McPherson EA. (1983). A reagin-like antibody in horse serum. II. Anti-human IgE induced reversed cutaneous anaphylaxis-like responses in horse skin. Vet Res Commun, 6(2), 111-122. https://doi.org/10.1007/BF02214903

Publication

Veterinary research communications
ISSN: 0165-7380
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 6
Issue: 2
Pages: 111-122

Researcher Affiliations

Matthews, A G
    Imlah, P
      McPherson, E A

        MeSH Terms

        • Animals
        • Antibodies / immunology
        • Antibodies, Anti-Idiotypic / immunology
        • Horses / immunology
        • Humans
        • Immunoglobulin E / immunology
        • Immunoglobulin G / immunology
        • Intradermal Tests
        • Passive Cutaneous Anaphylaxis
        • Reagins / immunology
        • Sheep / immunology

        References

        This article includes 19 references
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        Citations

        This article has been cited 0 times.
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