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Home / Equine Research Bank / J Equine Sci / A retrospective comparison of induction with thiopental/guai...
Journal of equine science2019; 30(2); 25-31; doi: 10.1294/jes.30.25

A retrospective comparison of induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery.

Abstract: This study compares clinical characteristics between induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine. Clinical records of 214 horses that underwent arthroscopic surgery between 2015 and 2016 were retrospectively retrieved. Horses were premedicated with medetomidine and midazolam to sedate at the adequate level for smooth induction, and then induced with either thiopental (4.0 mg/kg) and guaifenesin (100 mg/kg) in Group TG (n=91) or propofol (1.0 mg/kg) and ketamine (1.0 mg/kg) in Group PK (n=123). Anesthesia was maintained using sevoflurane with constant rate infusion of medetomidine. Quality of induction/recovery, sevoflurane requirement, cardiovascular function and recovery characteristics were evaluated. Anesthetic induction scores (median, range) for Group TG (5, 2-5) and Group PK (5, 2-5) were not significantly different. There were no significant differences in end-tidal sevoflurane concentration (mean ± standard deviation) between Group TG and Group PK (both 2.4 ± 0.2%). Dobutamine infusion rate (µg/kg/min) required for keeping mean arterial blood pressure (MAP) above 70 mmHg in Group PK (0.43, 0.10-1.40) was significantly lower than in Group TG (0.67, 0.08-1.56). Recovery score in Group PK (5, 2-5) was significantly higher than in Group TG (4, 2-5). Both propofol/ketamine and thiopental/guaifenesin provided a smooth induction of anesthesia. Moreover, induction with propofol/ketamine resulted in lower dobutamine requirements for keeping MAP above 70 mmHg during maintenance, and better quality of recovery. Induction with propofol/ketamine would be preferable to thiopental/guaifenesin in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery.
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Publication Date: 2019-07-03 PubMed ID: 31285690PubMed Central: PMC6606449DOI: 10.1294/jes.30.25Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research compares two methods of anesthetic induction – one with thiopental/guaifenesin and the other with propofol/ketamine – in Thoroughbred racehorses undergoing arthroscopic surgery. In summary, both methods provided smooth induction, but horses induced with propofol/ketamine needed less dobutamine to maintain blood pressure and had better recovery than horses induced with thiopental/guaifenesin.

Study Methodology

  • The researchers conducted a retrospective study looking at clinical records of 214 Thoroughbred racehorses that underwent arthroscopic surgery between 2015 and 2016.
  • The horses were premedicated with medetomidine and midazolam to reach an adequate level of sedation for smooth induction. They were then induced with either thiopental/guaifenesin (Group TG) or propofol/ketamine (Group PK).
  • Anesthesia maintenance was performed using sevoflurane combined with a constant infusion of medetomidine.
  • The team assessed differing factors including the quality of induction and recovery, sevoflurane requirements, cardiovascular function and recovery characteristics.

Findings

  • While both methods provided effective induction, there were no significant differences in anesthetic induction scores between both groups. Likewise, the end-tidal sevoflurane concentration was comparable in both groups.
  • The rate of dobutamine infusion required to maintain mean arterial blood pressure (MAP) above 70mmHg was significantly lower in the propofol/ketamine group than the thiopental/guaifenesin group. This suggests that the propofol/ketamine combination was more effective at keeping the horses’ blood pressure steady during the surgery.
  • Recovery was also rated significantly better in horses in the propofol/ketamine group compared to those in the thiopental/guaifenesin group. This indicates that horses anesthetized with propofol/ketamine woke up more easily and with fewer side effects.

Conclusion

  • The study concludes that while both methods performed well for inducing anesthesia, propofol/ketamine was the preferable choice due to lower dobutamine requirements and its association with a superior recovery experience.
  • The findings suggest that using propofol/ketamine as the method of induction in Thoroughbred racehorses who undergo arthroscopic surgery and are anesthetized with sevoflurane and medetomidine may lead to smoother and safer surgical experiences for the animals.

Cite This Article

APA
Tokushige H, Araki M, Kusano K, Arima D, Ito H, Yamazaki Y, Urayama S, Kambayashi Y, Tateno O, Ohta M. (2019). A retrospective comparison of induction with thiopental/guaifenesin and propofol/ketamine in Thoroughbred racehorses anesthetized with sevoflurane and medetomidine during arthroscopic surgery. J Equine Sci, 30(2), 25-31. https://doi.org/10.1294/jes.30.25

Publication

Journal of equine science
ISSN: 1340-3516
NlmUniqueID: 9503751
Country: Japan
Language: English
Volume: 30
Issue: 2
Pages: 25-31

Researcher Affiliations

Tokushige, Hirotaka
  • Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.
Araki, Masanari
  • Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
Kusano, Kanichi
  • Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
Arima, Daisuke
  • Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
Ito, Hideki
  • Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
Yamazaki, Yosuke
  • Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
Urayama, Shuntaro
  • Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
Kambayashi, Yoshinori
  • Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
Tateno, Oki
  • Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
Ohta, Minoru
  • Equine Research Institute, Japan Racing Association, Tochigi 329-0412, Japan.

References

This article includes 23 references
  1. Aida H, Mizuno Y, Hobo S, Yoshida K, Fujinaga T. Cardiovascular and pulmonary effects of sevoflurane anesthesia in horses.. Vet Surg 1996 Mar-Apr;25(2):164-70.
    pubmed: 8928394doi: 10.1111/j.1532-950x.1996.tb01393.xgoogle scholar: lookup
  2. Bennett RC, Taylor PM, Brearley JC, Johnson CB, Luna SP. Comparison of detomidine/ketamine and guaiphenesin/thiopentone for induction of anaesthesia in horses maintained with halothane.. Vet Rec 1998 May 16;142(20):541-5.
    pubmed: 9637380doi: 10.1136/vr.142.20.541google scholar: lookup
  3. Bettschart-Wolfensberger R, Bettschart R.W., Vainio O, Marlin D, Clarke K.W.. Cardiopulmonary effects of a two hour infusion of medetomidine and its reversal by atipamezole in horses and ponies. J. Vet. Anaesth. 1999;26:8–12.
  4. Bettschart-Wolfensberger R, Freeman SL, Jäggin-Schmucker N, Clarke KW. Infusion of a combination of propofol and medetomidine for long-term anesthesia in ponies.. Am J Vet Res 2001 Apr;62(4):500-7.
    pubmed: 11327455doi: 10.2460/ajvr.2001.62.500google scholar: lookup
  5. Bettschart-Wolfensberger R, Bowen IM, Freeman SL, Weller R, Clarke KW. Medetomidine-ketamine anaesthesia induction followed by medetomidine-propofol in ponies: infusion rates and cardiopulmonary side effects.. Equine Vet J 2003 May;35(3):308-13.
    pubmed: 12755436doi: 10.2746/042516403776148354google scholar: lookup
  6. Brouwer GJ. Short duration general anaesthesia in the horse using guaiacol glycerine ether and thiopentone sodium.. Equine Vet J 1985 May;17(3):252-4.
    pubmed: 4076138doi: 10.1111/j.2042-3306.1985.tb02488.xgoogle scholar: lookup
  7. Bueno AC, Cornick-Seahorn J, Seahorn TL, Hosgood G, Moore RM. Cardiopulmonary and sedative effects of intravenous administration of low doses of medetomidine and xylazine to adult horses.. Am J Vet Res 1999 Nov;60(11):1371-6.
    pubmed: 10566811
  8. Duke-Novakovski T, Palacios-Jimenez C, Wetzel T, Rymes L, Sanchez-Teran AF. Cardiopulmonary effects of dexmedetomidine and ketamine infusions with either propofol infusion or isoflurane for anesthesia in horses.. Vet Anaesth Analg 2015 Jan;42(1):39-49.
    pubmed: 24984762doi: 10.1111/vaa.12194google scholar: lookup
  9. Gangl M, Grulke S, Detilleux J, Caudron I, Serteyn D. Comparison of thiopentone/guaifenesin, ketamine/guaifenesin and ketamine/midazolam for the induction of horses to be anaesthetised with isoflurane.. Vet Rec 2001 Aug 4;149(5):147-51.
    pubmed: 11517983doi: 10.1136/vr.149.5.147google scholar: lookup
  10. Hubbell JA, Muir WW, Sams RA. Guaifenesin: cardiopulmonary effects and plasma concentrations in horses.. Am J Vet Res 1980 Nov;41(11):1751-5.
    pubmed: 7212404
  11. Jarrett MA, Bailey KM, Messenger KM, Prange T, Gaines B, Posner LP. Recovery of horses from general anesthesia after induction with propofol and ketamine versus midazolam and ketamine.. J Am Vet Med Assoc 2018 Jul 1;253(1):101-107.
    pubmed: 29911938doi: 10.2460/javma.253.1.101google scholar: lookup
  12. Mama KR, Steffey EP, Pascoe PJ. Evaluation of propofol as a general anesthetic for horses.. Vet Surg 1995 Mar-Apr;24(2):188-94.
    pubmed: 7778261doi: 10.1111/j.1532-950x.1995.tb01317.xgoogle scholar: lookup
  13. Mama KR, Steffey EP, Pascoe PJ. Evaluation of propofol for general anesthesia in premedicated horses.. Am J Vet Res 1996 Apr;57(4):512-6.
    pubmed: 8712516
  14. Muir WW 3rd, Lerche P, Robertson JT, Hubbell JA, Beard W, Miller T, Badgley B, Bothwell V. Comparison of four drug combinations for total intravenous anesthesia of horses undergoing surgical removal of an abdominal testis.. J Am Vet Med Assoc 2000 Sep 15;217(6):869-73.
    pubmed: 10997159doi: 10.2460/javma.2000.217.869google scholar: lookup
  15. Nolan A, Reid J, Welsh E, Flaherty D, McCormack R, Monteiro AM. Simultaneous infusions of propofol and ketamine in ponies premedicated with detomidine: a pharmacokinetic study.. Res Vet Sci 1996 May;60(3):262-6.
    pubmed: 8735519doi: 10.1016/s0034-5288(96)90051-xgoogle scholar: lookup
  16. Oku K, Ohta M, Katoh T, Moriyama H, Kusano K, Fujinaga T. Cardiovascular effects of continuous propofol infusion in horses.. J Vet Med Sci 2006 Aug;68(8):773-8.
    pubmed: 16953074doi: 10.1292/jvms.68.773google scholar: lookup
  17. Posner LP, Kasten JI, Kata C. Propofol with ketamine following sedation with xylazine for routine induction of general anaesthesia in horses.. Vet Rec 2013 Dec 7;173(22):550.
    pubmed: 24218416doi: 10.1136/vr.101906google scholar: lookup
  18. Steffey EP, Mama KR, Galey FD, Puschner B, Woliner MJ. Effects of sevoflurane dose and mode of ventilation on cardiopulmonary function and blood biochemical variables in horses.. Am J Vet Res 2005 Apr;66(4):606-14.
    pubmed: 15900940doi: 10.2460/ajvr.2005.66.606google scholar: lookup
  19. Tokushige H, Ohta M, Okano A, Kuroda T, Kakizaki M, Ode H, Aoki M, Wakuno A, Kawasaki K. Effects of medetomidine constant rate infusion on sevoflurane requirement, cardiopulmonary function, and recovery quality in thoroughbred racehorses undergoing arthroscopic surgery. J. Equine Vet. Sci. 2015;35:83–87.
  20. Tokushige H, Okano A, Arima D, Ito H, Kambayashi Y, Minamijima Y, Ohta M. Clinical effects of constant rate infusions of medetomidine-propofol combined with sevoflurane anesthesia in Thoroughbred racehorses undergoing arthroscopic surgery.. Acta Vet Scand 2018 Nov 5;60(1):71.
    pmc: PMC6217774pubmed: 30396363doi: 10.1186/s13028-018-0426-0google scholar: lookup
  21. Wagner AE, Mama KR, Steffey EP, Brevard LF, Hellyer PW. Behavioral responses following eight anesthetic induction protocols in horses.. Vet Anaesth Analg 2002 Oct;29(4):207-211.
    pubmed: 28404364doi: 10.1046/j.1467-2995.2002.00093.xgoogle scholar: lookup
  22. Yamashita K, Tsubakishita S, Futaok S, Ueda I, Hamaguchi H, Seno T, Katoh S, Izumisawa Y, Kotani T, Muir WW. Cardiovascular effects of medetomidine, detomidine and xylazine in horses.. J Vet Med Sci 2000 Oct;62(10):1025-32.
    pubmed: 11073071doi: 10.1292/jvms.62.1025google scholar: lookup
  23. Young SS, Taylor PM. Factors influencing the outcome of equine anaesthesia: a review of 1,314 cases.. Equine Vet J 1993 Mar;25(2):147-51.
    pubmed: 8467775doi: 10.1111/j.2042-3306.1993.tb02926.xgoogle scholar: lookup

Citations

This article has been cited 1 times.
  1. Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
    doi: 10.3390/ani11061777pubmed: 34198637google scholar: lookup
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