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Home / Equine Research Bank / J Vet Diagn Invest / A retrospective histologic study of 140 cases of clinically ...
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc2020; 32(3); 382-388; doi: 10.1177/1040638720912698

A retrospective histologic study of 140 cases of clinically significant equine ocular disorders.

Abstract: Ocular diseases are an important category in equine medicine; however, most articles regarding histologic ocular lesions in horses are exclusive to a specific condition and do not provide a complete review of clinically significant ocular disease frequency in a diagnostic laboratory. We reviewed sections of equine eyes from 140 cases (98 enucleations [biopsies] and 42 autopsies) with clinically relevant ocular alterations at 2 diagnostic centers in the United States. The most common primary conditions were non-traumatic keratitis (36), equine recurrent uveitis (ERU; 31), traumatic injuries (22), ocular and periocular neoplasms (19), and uveitis and/or endophthalmitis resulting from sepsis (18). Congenital anomalies (3) and retinal atrophy and detachment alone (3) were infrequent. Non-traumatic keratitis was frequently accompanied by anterior uveitis (22), corneal rupture (16), pre-iridal fibrovascular membrane formation (13), and secondary mycotic infection (11). ERU was the second and third most prevalent disease in autopsies and enucleations, respectively. This condition was commonly associated with glaucoma (15). Glaucoma (25) and cataract (20) were the most prevalent secondary alterations in the evaluated cases. Keratitis (20) and corneal rupture (16) were among the most prevalent consequences of trauma. Information presented herein may guide clinicians and pathologists, contributing to the early diagnosis of potentially vision-impairing conditions and raising the chances of successful treatment and cure.
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Publication Date: 2020-03-24 PubMed ID: 32207378PubMed Central: PMC7377627DOI: 10.1177/1040638720912698Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article explores the occurrence, impact, and co-conditions of various eye-related diseases in horses, drawing upon data collected from clinical observations and autopsies.

Study Methodology

  • The study adopted a retrospective histologic approach, analyzing samples from 140 instances of significant equine ocular disorders. These instances include a mix of in vivo and post-mortem samples, with 98 observations from eye biopsies (enucleations) and 42 autopsies.
  • The research was conducted at two diagnostic centers located in the United States, pooling these cases to provide a wider perspective on equine ocular diseases.

Findings

  • The most common condition found in this diverse range of cases was non-traumatic keratitis, with 36 instances. This was often seen alongside anterior uveitis, corneal rupture, formation of pre-iridal fibrovascular membranes, and secondary mycotic infection.
  • The second most common condition was equine recurrent uveitis (ERU), with 31 instances. This was noticeably prevalent in both autopsies and enucleations, frequently associated with another ocular disorder, glaucoma.
  • Other common disorders included traumatic injuries (22 instances), ocular and periocular tumors (19 instances), and uveitis or endophthalmitis resulting from sepsis (18 instances).
  • Infrequent conditions that appeared in the studied population were congenital anomalies, and retinal atrophy or detachment.

Secondary Alterations and Consequences

  • Glaucoma and cataracts were the most commonly observed secondary changes in the cases studied, with 25 and 20 instances respectively.
  • Corneal rupture and keratitis were the most frequently observed consequences following equine ocular traumatic injuries.

Impact of the Research

  • The collective data from this research can prove valuable to equine clinicians and pathologists, offering key insights into common and rare ocular disorders, their impacts, and associated conditions.
  • As a comprehensive review of histologic findings on equine ocular lesions, it can aid in the early diagnosis of potential vision-impairing conditions, thus improving chances of successful treatment and cure.

Cite This Article

APA
Flores MM, Del Piero F, Habecker PL, Langohr IM. (2020). A retrospective histologic study of 140 cases of clinically significant equine ocular disorders. J Vet Diagn Invest, 32(3), 382-388. https://doi.org/10.1177/1040638720912698

Publication

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
ISSN: 1943-4936
NlmUniqueID: 9011490
Country: United States
Language: English
Volume: 32
Issue: 3
Pages: 382-388

Researcher Affiliations

Flores, Mariana M
  • Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA (Flores, Del Piero, Langohr).
  • Large Animal Pathology Service, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA (Habecker).
  • Current address: Departamento de Patologia, Laboratório de Patologia Veterinária, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil (Flores).
Del Piero, Fabio
  • Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA (Flores, Del Piero, Langohr).
  • Large Animal Pathology Service, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA (Habecker).
  • Current address: Departamento de Patologia, Laboratório de Patologia Veterinária, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil (Flores).
Habecker, Perry L
  • Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA (Flores, Del Piero, Langohr).
  • Large Animal Pathology Service, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA (Habecker).
  • Current address: Departamento de Patologia, Laboratório de Patologia Veterinária, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil (Flores).
Langohr, Ingeborg M
  • Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA (Flores, Del Piero, Langohr).
  • Large Animal Pathology Service, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA (Habecker).
  • Current address: Departamento de Patologia, Laboratório de Patologia Veterinária, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil (Flores).

MeSH Terms

  • Animals
  • Eye Diseases / epidemiology
  • Eye Diseases / pathology
  • Eye Diseases / veterinary
  • Female
  • Horse Diseases / epidemiology
  • Horse Diseases / pathology
  • Horses
  • Louisiana / epidemiology
  • Male
  • Pennsylvania / epidemiology
  • Prevalence
  • Retrospective Studies

Conflict of Interest Statement

Declaration of conflicting interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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