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International journal of implant dentistry2021; 7(1); 60; doi: 10.1186/s40729-021-00336-9

A retrospective preliminary histomorphometric and clinical investigation on sinus augmentation using enzyme-deantigenic, collagen-preserving equine bone granules and plasma rich in growth factors.

Abstract: Enzyme-deantigenic equine bone (EDEB) is a substitute of autogenous bone. Mixing it with plasma rich in growth factors (PRGF) seems a viable option to achieve enhanced bone formation in alveolar bone augmentation surgeries. This retrospective study aims to first report the histomorphometric and clinical outcomes achieved when using the EDEB/PRGF mixture for performing sinus augmentation procedures followed by delayed implant placement. Records of 11 patients who underwent 14 sinus augmentation surgeries using EDEB/PRGF followed by delayed implant placement were retrospectively collected and analyzed to assess histomorphometric data concerning newly formed bone (NFB) and residual biomaterial (RB) recorded at implant placement, marginal bone loss (MBL) values of implants placed in the augmented sinuses, and implant and prosthetic success and survival rates. At 5.6 ± 1.1 months after grafting, NFB and RB were 34.0 ± 9.1% and 11.3 ± 2.2% respectively, and no histologic signs of inflammation or immune reaction were observed in any of the 34 bone biopsies being collected. Further, 86.5 ± 4.3 months after implant placement, MBL was 0.40 ± 0.07 mm. No implant or prosthesis failed, and the implant success and survival rates were 100% CONCLUSIONS: Within the limitations of the present study, grafting EDEB/PRGF for lateral sinus augmentation and delayed implant placement seems to be safe. Compared to published data concerning EDEB alone, results of the present study do not suggest that the EDEB/PRGF combination may provide a histomorphometric or medium-/long-term clinical advantage.
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Publication Date: 2021-06-11 PubMed ID: 34114113PubMed Central: PMC8192666DOI: 10.1186/s40729-021-00336-9Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study explores the effectiveness of using a combination of enzyme-deantigenic equine bone and plasma rich in growth factors for sinus augmentation surgeries and the subsequent placement of dental implants. In particular, it observes the histomorphometric and clinical outcomes, along with the success and survival rates of the implants and prostheses used in these procedures.

Methodology

  • The researchers conducted a retrospective study that involved analyzing the records of 11 patients who underwent 14 sinus augmentation procedures.
  • During these surgeries, the patients received grafts of enzyme-deantigenic equine bone combined with plasma rich growth factors for sinus augmentation, before having dental implants placed later.
  • The team analyzed the histomorphometric data, specifically looking for the amount of newly formed bone and residual biomaterial at the time of implant placement.
  • They also analyzed the rate of marginal bone loss around the implants placed in the augmented sinuses.
  • The rates of both implant and prosthetic success and survival were examined.

Results

  • Results showed that, on average, 5.6 months post grafting, the newly formed bone and residual biomaterial made up approximately 34.0% and 11.3% of the observed structures respectively.
  • No signs of inflammation or immune reaction were found in any of the 34 bone biopsies taken.
  • On average, about 86.5 months post implant placement, the marginal bone loss was measured to be 0.40 mm.
  • No observed failure of any implants or prostheses, therefore, implant success and survival rates were calculated to be 100%.

Conclusions

  • Despite study limitations, the research suggests that the combination of enzyme-deantigenic equine bone and plasma rich growth factors appears to be a safe method for performing lateral sinus augmentation and subsequent delayed implant placements.
  • When compared to data on the use of enzyme-deantigenic equine bone alone, there is no indication that mixing it with plasma rich growth factors offers any significant clinical or histomorphometric advantages over medium to long-term periods.

Cite This Article

APA
Di Stefano DA, Vinci R, Capparè P, Gherlone EF. (2021). A retrospective preliminary histomorphometric and clinical investigation on sinus augmentation using enzyme-deantigenic, collagen-preserving equine bone granules and plasma rich in growth factors. Int J Implant Dent, 7(1), 60. https://doi.org/10.1186/s40729-021-00336-9

Publication

International journal of implant dentistry
ISSN: 2198-4034
NlmUniqueID: 101676532
Country: Germany
Language: English
Volume: 7
Issue: 1
Pages: 60
PII: 60

Researcher Affiliations

Di Stefano, Danilo Alessio
  • Dental School, Vita-Salute University IRCCS San Raffaele, Milan, Italy. distefano@centrocivitali.it.
  • Private Practice, Milan, Italy. distefano@centrocivitali.it.
Vinci, Raffaele
  • Dental School, Vita-Salute University IRCCS San Raffaele, Milan, Italy.
Capparè, Paolo
  • Dental School, Vita-Salute University IRCCS San Raffaele, Milan, Italy.
Gherlone, Enrico Felice
  • Dental School, Vita-Salute University IRCCS San Raffaele, Milan, Italy.

MeSH Terms

  • Animals
  • Bone Substitutes
  • Bone Transplantation
  • Collagen
  • Horses
  • Humans
  • Maxillary Sinus / surgery
  • Osteogenesis
  • Retrospective Studies
  • Sinus Floor Augmentation

Conflict of Interest Statement

Danilo Alessio Di Stefano has a consultancy relationship with Bioteck S.p.A., which donated the equine xenografts used in this study. Data belonged to the authors, and none of the manufacturers cited in the study interfered with its execution or results.

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Citations

This article has been cited 2 times.
  1. Di Stefano DA, Orlando F, Ottobelli M, Fiori D, Garagiola U. A comparison between anorganic bone and collagen-preserving bone xenografts for alveolar ridge preservation: systematic review and future perspectives. Maxillofac Plast Reconstr Surg 2022 Jul 12;44(1):24.
    doi: 10.1186/s40902-022-00349-3pubmed: 35821286google scholar: lookup
  2. Orlando F, Foiani S, Dellavia C, Graziano D, Di Stefano DA. Horizontal GBR with anorganic equine bone combined with a customized titanium mesh. Clin Case Rep 2024 Apr;12(4):e8780.
    doi: 10.1002/ccr3.8780pubmed: 38659499google scholar: lookup
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