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Home / Equine Research Bank / Acta Vet Scand / A review of current knowledge of myeloproliferative disorder...
Acta veterinaria Scandinavica2021; 63(1); 8; doi: 10.1186/s13028-021-00573-3

A review of current knowledge of myeloproliferative disorders in the horse.

Abstract: Myeloid disorders are conditions being characterized by abnormal proliferation and development of myeloid lineage including granulocytes (neutrophils, eosinophils and basophils), monocytes, erythroids, and megakaryocytes precursor cells. Myeloid leukemia, based on clinical presentation and proliferative rate of neoplastic cells, is divided into acute (AML) and myeloproliferative neoplasms (MPN). The most commonly myeloid leukemia reported in horses are AML-M4 (myelomonocytic) and AML-M5 (monocytic). Isolated cases of AML-M6B (acute erythroid leukemia), and chronic granulocytic leukemia have also been reported. Additionally, bone marrow disorders with dysplastic alterations and ineffective hematopoiesis affecting single or multiple cell lineages or myelodysplastic diseases (MDS), have also been reported in horses. MDSs have increased myeloblasts numbers in blood or bone marrow, although less than 20%, which is the minimum level required for diagnosis of AML. This review performed a detailed description of the current state of knowlegde of the myeloproliferative disorders in horses following the criteria established by the World Health Organization.
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Publication Date: 2021-02-23 PubMed ID: 33622355PubMed Central: PMC7903742DOI: 10.1186/s13028-021-00573-3Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article reviews the current knowledge on a group of diseases in horses known as myeloproliferative disorders, particularly those affecting the development and growth of blood cells from the myeloid lineage.

Understanding Myeloid Disorders in Horses

  • The review focuses on conditions identified as myeloid disorders, characterized by abnormal proliferation and development of certain blood cells in the myeloid lineage. These include granulocytes (neutrophils, eosinophils, basophils), monocytes, erythroids, and megakaryocytes precursors.
  • Myeloid leukemia comes under these disorders, which can further be segmented into acute (AML) and myeloproliferative neoplasms (MPN) based on clinical presentation and the proliferation rate associated with the cancerous cells.

Common Types of Myeloid Leukemia in Horses

  • The most common types of myeloid leukemia reported in horses include AML-M4 (myelomonocytic) and AML-M5 (monocytic).
  • The research paper also discusses some rare cases of AML-M6B (acute erythroid leukemia) and chronic granulocytic leukemia in horses.

Myelodysplastic Diseases (MDS) and Their Presence in Horses

  • In addition to myeloid leukemia, the research also reviews myelodysplastic diseases (MDS). MDS are bone marrow disorders that cause ineffective hematopoiesis affecting a single or multiple cell lines.
  • Horses with MDS have been reported to show increased numbers of myeloblasts in their blood or bone marrow, but not to the level required for an AML diagnosis (less than 20%).

Scope of the Review

  • The review provides a detailed description of the current state of knowledge on myeloproliferative disorders in horses following the criteria outlined by the World Health Organization.

Cite This Article

APA
Satué K, Gardon JC, Muñoz A. (2021). A review of current knowledge of myeloproliferative disorders in the horse. Acta Vet Scand, 63(1), 8. https://doi.org/10.1186/s13028-021-00573-3

Publication

Acta veterinaria Scandinavica
ISSN: 1751-0147
NlmUniqueID: 0370400
Country: England
Language: English
Volume: 63
Issue: 1
Pages: 8
PII: 8

Researcher Affiliations

Satué, Katy
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, Cardenal Herrera University, Tirant Lo Blanc, 7, Alfara del Patriarca, 46115, Valencia, Spain. ksatue@uchceu.es.
  • Department of Animal Medicine and Surgery, School of Veterinary and Experimental Sciences, Catholic University of Valencia-San Vicente Mártir, Guillem de Castro, 106, 46003, Valencia, Spain. ksatue@uchceu.es.
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, University of Córdoba, University Campus of Rabanales, Ctra. Madrid-Cádiz, 14014, Córdoba, Spain. ksatue@uchceu.es.
Gardon, Juan Carlos
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, Cardenal Herrera University, Tirant Lo Blanc, 7, Alfara del Patriarca, 46115, Valencia, Spain.
  • Department of Animal Medicine and Surgery, School of Veterinary and Experimental Sciences, Catholic University of Valencia-San Vicente Mártir, Guillem de Castro, 106, 46003, Valencia, Spain.
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, University of Córdoba, University Campus of Rabanales, Ctra. Madrid-Cádiz, 14014, Córdoba, Spain.
Muñoz, Ana
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, Cardenal Herrera University, Tirant Lo Blanc, 7, Alfara del Patriarca, 46115, Valencia, Spain.
  • Department of Animal Medicine and Surgery, School of Veterinary and Experimental Sciences, Catholic University of Valencia-San Vicente Mártir, Guillem de Castro, 106, 46003, Valencia, Spain.
  • Department of Animal Medicine and Surgery, Faculty of Veterinary, University of Córdoba, University Campus of Rabanales, Ctra. Madrid-Cádiz, 14014, Córdoba, Spain.

MeSH Terms

  • Animals
  • Horse Diseases / diagnosis
  • Horses
  • Myeloproliferative Disorders / diagnosis
  • Myeloproliferative Disorders / veterinary

Conflict of Interest Statement

The authors declare that they have no competing interests.

References

This article includes 60 references
  1. Kelton DR, Holbrook TC, Gilliam LL, Rizzi TE, Brosnahan MM, Confer AW. Bone marrow necrosis and myelophthisis: manifestations of T-cell lymphoma in a horse.. Vet Clin Pathol 2008 Dec;37(4):403-8.
    doi: 10.1111/j.1939-165X.2008.00069.xpubmed: 19055575google scholar: lookup
  2. Muñoz A, Riber C, Trigo P, Castejón F. Hematopoietic neoplasias in horses: myeloproliferative and lymphoproliferative disorders.. J Equine Sci 2009;20(4):59-72.
    doi: 10.1294/jes.20.59pmc: PMC4013965pubmed: 24833969google scholar: lookup
  3. Bienzle D. Hematopoietic neoplasia. In: Latimer KS, editor. Duncan and Prasse's Veterinary Laboratory Medicine: Clinical Pathology. 5. New York: Wiley-Blackwell; 2011. pp. 83–105.
  4. Cooper CJ, Keller SM, Arroyo LG, Hewson J, Kenney D, Bienzle D. Acute Leukemia in Horses.. Vet Pathol 2018 Jan;55(1):159-172.
    pubmed: 28812528doi: 10.1177/0300985817720983google scholar: lookup
  5. Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW. The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.. Blood 2016 May 19;127(20):2391-405.
    doi: 10.1182/blood-2016-03-643544pubmed: 27069254google scholar: lookup
  6. Valli V, Kiupel M, Bienzle D. The hematopoietic system. In: Maxie MG, editor. Jubb, Kennedy and Palmer’s Pathology of Domestic Animals. 6. Oxford, UK: Elsevier Health Sciences UK; 2015. pp. 102–268.
  7. Jaffe ES, Harris NL, Stein H. World Health Organization classification of tumours: pathology and genetics of tumors of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001. pp. 20–28.
  8. Dobson J, Villiers E, Morris J. Diagnosis and management of leukaemia in dogs and cats. Practice 2006;28:22–31.
    doi: 10.1136/inpract.28.1.22google scholar: lookup
  9. Savage CJ. Lymphoproliferative and myeloproliferative disorders.. Vet Clin North Am Equine Pract 1998 Dec;14(3):563-78, vii.
    doi: 10.1016/S0749-0739(17)30187-6pubmed: 9891725google scholar: lookup
  10. Durando MM, Alleman AR, Harvey JW. Myelodysplastic syndrome in a quarter horse gelding.. Equine Vet J 1994 Jan;26(1):83-5.
    doi: 10.1111/j.2042-3306.1994.tb04339.xpubmed: 8143673google scholar: lookup
  11. Taintor J. Equine leukaemia. Equine Vet Educ 2012;12:604–609.
    doi: 10.1111/j.2042-3292.2012.00458.xgoogle scholar: lookup
  12. Miglio A, Pepe M, Felippe MJB, Antognoni MT. Subleukaemic acute myeloid leukaemia with myelodysplasia in a horse. Equine Vet Educ 2019;31:e39–e46.
    doi: 10.1111/eve.12983google scholar: lookup
  13. Steinbach F, Stark R, Ibrahim S, Gawad EA, Ludwig H, Walter J, Commandeur U, Mauel S. Molecular cloning and characterization of markers and cytokines for equid myeloid cells.. Vet Immunol Immunopathol 2005 Oct 18;108(1-2):227-36.
    doi: 10.1016/j.vetimm.2005.07.015pubmed: 16112744google scholar: lookup
  14. McClure JT, Young KM, Fiste M, Sharkey LC, Lunn DP. Immunophenotypic classification of leukemia in 3 horses.. J Vet Intern Med 2001 Mar-Apr;15(2):144-52.
    doi: 10.1111/j.1939-1676.2001.tb01247.xpubmed: 11300598google scholar: lookup
  15. McManus PM. Classification of myeloid neoplasms: a comparative review.. Vet Clin Pathol 2005 Sep;34(3):189-212.
    doi: 10.1111/j.1939-165X.2005.tb00042.xpubmed: 16134066google scholar: lookup
  16. Miglio A, Antognoni MT, Miniscalco B, Caivano D, Lepri E, Birettoni F, Mangili V. Acute undifferentiated leukaemia in a dog.. Aust Vet J 2014 Dec;92(12):499-503.
    doi: 10.1111/avj.12273pubmed: 25424765google scholar: lookup
  17. Clark P, Cornelisse CJ, Schott HC, Swenson CL, Bell TG. Myeloblastic leukaemia in a Morgan horse mare.. Equine Vet J 1999 Sep;31(5):446-8.
    doi: 10.1111/j.2042-3306.1999.tb03847.xpubmed: 10505963google scholar: lookup
  18. Raskin RE. Diagnostic Tools and Dilemmas With Equine Leukemias.. Vet Pathol 2018 Jan;55(1):11-13.
    doi: 10.1177/0300985817738315pubmed: 29254473google scholar: lookup
  19. Bienzle D, Hughson SL, Vernau W. Acute myelomonocytic leukemia in a horse.. Can Vet J 1993 Jan;34(1):36-7.
    pmc: PMC1686361pubmed: 17424144
  20. Blue J, Perdrizet J, Brown E. Pulmonary aspergillosis in a horse with myelomonocytic leukemia.. J Am Vet Med Assoc 1987 Jun 15;190(12):1562-4.
    pubmed: 3475266
  21. Boudreaux MK, Blue JT, Durham SK, Vivrette SL. Intravascular leukostasis in a horse with myelomonocytic leukemia.. Vet Pathol 1984 Sep;21(5):544-6.
    pubmed: 6592873doi: 10.1177/030098588402100521google scholar: lookup
  22. Brumbaugh GW, Stitzel KA, Zinkl JG, Feldman BF. Myelomonocytic myeloproliferative diseases in a horse.. J Am Vet Med Assoc 1982 Feb 1;180(3):313-6.
    pubmed: 7056685
  23. Buechner-Maxwell V, Zhang C, Robertson J, Jain NC, Antczak DF, Feldman BF, Murray MJ. Intravascular leukostasis and systemic aspergillosis in a horse with subleukemic acute myelomonocytic leukemia.. J Vet Intern Med 1994 Jul-Aug;8(4):258-63.
    pubmed: 7983620doi: 10.1111/j.1939-1676.1994.tb03229.xgoogle scholar: lookup
  24. Mori T, Ishida T, Washizu T, Yamagami T, Umeda M, Sugiyama M, Motoyoshi S. Acute myelomonocytic leukemia in a horse.. Vet Pathol 1991 Jul;28(4):344-6.
    doi: 10.1177/030098589102800415pubmed: 1659022google scholar: lookup
  25. Ringger NC, Edens L, Bain P, Raskin RE, Larock R. Acute myelogenous leukaemia in a mare.. Aust Vet J 1997 May;75(5):329-31.
    doi: 10.1111/j.1751-0813.1997.tb15702.xpubmed: 9196816google scholar: lookup
  26. Spier SJ, Madewell BR, Zinkl JG, Ryan AM. Acute myelomonocytic leukemia in a horse.. J Am Vet Med Assoc 1986 Apr 15;188(8):861-3.
    pubmed: 3458690
  27. Burkhardt E, von Saldern F, Huskamp B. Monocytic leukemia in a horse.. Vet Pathol 1984 Jul;21(4):394-8.
    doi: 10.1177/030098588402100405pubmed: 6589870google scholar: lookup
  28. Monteith CN, Cole D. Monocytic leukemia in a horse.. Can Vet J 1995 Dec;36(12):765-6.
    pmc: PMC1687078pubmed: 8748445
  29. Latimer KS, White SL. Acute monocytic leukaemia (M5a) in a horse. Comp Haematol Int 1996;6:111–114.
    doi: 10.1007/BF00426052google scholar: lookup
  30. Mylonakis ME, Kritsepi-Konstantinou M, Vernau W, Valli VE, Pardali D, Koutinas AF. Presumptive pure erythroid leukemia in a dog.. J Vet Diagn Invest 2012 Sep;24(5):1004-7.
    doi: 10.1177/1040638712452731pubmed: 22807506google scholar: lookup
  31. Forbes G, Feary DJ, Savage CJ, Nath L, Church S, Lording P. Acute myeloid leukaemia (M6B: pure acute erythroid leukaemia) in a Thoroughbred foal.. Aust Vet J 2011 Jul;89(7):269-72.
    doi: 10.1111/j.1751-0813.2011.00790.xpubmed: 21696377google scholar: lookup
  32. Panziera W, Tessele B, BianchiI R, Tochetto C, De La Corte F, Brass K, Fighera R. Equine acute erythroid leukemia. Ciência Rural 2015;45:2214–2217.
    doi: 10.1590/0103-8478cr20140876google scholar: lookup
  33. Comazzi S, Gelain ME, Bonfanti U, Roccabianca P. Acute megakaryoblastic leukemia in dogs: a report of three cases and review of the literature.. J Am Anim Hosp Assoc 2010 Sep-Oct;46(5):327-35.
    doi: 10.5326/0460327pubmed: 20810553google scholar: lookup
  34. Mears EA, Raskin RE, Legendre AM. Basophilic leukemia in a dog.. J Vet Intern Med 1997 Mar-Apr;11(2):92-4.
    doi: 10.1111/j.1939-1676.1997.tb00079.xpubmed: 9127296google scholar: lookup
  35. Iwanaga T, Miura N, Miyoshi N, Endo Y, Momoi Y. Abnormal erythroid cell proliferation and myelofibrosis in a cat.. J Vet Med Sci 2012 Jul;74(7):909-12.
    doi: 10.1292/jvms.11-0268pubmed: 22313965google scholar: lookup
  36. Takahashi Y, Yoneyama S, Yamamoto S, Shibahara T, Kadota K. Acute basophilic leukaemia in a calf.. Vet Rec 2006 May 20;158(20):702-3.
    doi: 10.1136/vr.158.20.702pubmed: 16714438google scholar: lookup
  37. Furness MC, Setlakwe E, Sallaway J, Wood D, Fromstein J, Arroyo LG. Acute myeloid leukemia with basophilic differentiation in a 3-year-old Standardbred gelding.. Can Vet J 2016 Oct;57(10):1067-1071.
    pmc: PMC5026147pubmed: 27708445
  38. Searcy GP, Orr JP. Chronic granulocytic leukemia in a horse.. Can Vet J 1981 May;22(5):148-51.
    pmc: PMC1790045pubmed: 6941847
  39. Johansson AM, Skidell J, Lilliehöök I, Tvedten HW. Chronic granulocytic leukemia in a horse.. J Vet Intern Med 2007 Sep-Oct;21(5):1126-9.
    doi: 10.1111/j.1939-1676.2007.tb03076.xpubmed: 17939576google scholar: lookup
  40. Latimer KS, Andreasen CB. Bone Marrow. In: Cowell R, Tyler R, editors. Diagnostic Cytology and Hematology of the Horse. 2. New York: Mosby; 2002. pp. 217–226.
  41. Kumar A, Sinha S, Tripathi AK. Chronic eosinophilic leukemia: a case report and review of literature.. Indian J Hematol Blood Transfus 2007 Dec;23(3-4):112-5.
    doi: 10.1007/s12288-008-0010-2pmc: PMC3453119pubmed: 23100928google scholar: lookup
  42. Morris DD, Bloom JC, Roby KA, Woods K, Tablin F. Eosinophilic myeloproliferative disorder in a horse.. J Am Vet Med Assoc 1984 Nov 1;185(9):993-6.
    pubmed: 6511643
  43. Schumacher J, Spano JS, Oliver JL, Smith RA. Hypereosinophilic syndrome in an American paint horse. J Equine Vet Sci 1991;12:346–348.
    doi: 10.1016/S0737-0806(06)81264-5google scholar: lookup
  44. Cehreli C, Ates H, Cehreli R, Sercan Z, Demirkan F. New paraneoplastic syndrome in chronic basophilic leukemia.. Int J Hematol 2013 Apr;97(4):498-504.
    doi: 10.1007/s12185-013-1281-4pubmed: 23413035google scholar: lookup
  45. Mochizuki H, Seki T, Nakahara Y, Tomita A, Takahashi M, Fujino Y, Ohno K, Tsujimoto H. Chronic myelogenous leukaemia with persistent neutrophilia, eosinophilia and basophilia in a cat.. J Feline Med Surg 2014 Jun;16(6):517-21.
    pubmed: 24108200doi: 10.1177/1098612x13505576google scholar: lookup
  46. Azakami D, Saito A, Ochiai K, Ishiwata T, Takahashi K, Kaji N, Kaji D, Kaji N, Michishita M. Chronic Basophilic Leukaemia in a Dog.. J Comp Pathol 2019 Jan;166:5-8.
    doi: 10.1016/j.jcpa.2018.10.170pubmed: 30691606google scholar: lookup
  47. Sellon DC, Wise LN. Disorders of the hematopoietic system. In: Reed SM, Bayly WM, Sellon DC 3rd, editors. Equine Internal Medicine. New York: Saunders; 2010. pp. 730–776.
  48. McFarlane D, Sellon DC, Parker B. Primary erythrocytosis in a 2-year-old Arabian gelding.. J Vet Intern Med 1998 Sep-Oct;12(5):384-8.
    doi: 10.1111/j.1939-1676.1998.tb02139.xpubmed: 9773416google scholar: lookup
  49. Steiger R, Feige K. [Case report: polycythemia in a horse].. Schweiz Arch Tierheilkd 1995;137(7):306-11.
    pubmed: 7569845
  50. Spivak JL. Polycythemia Vera.. Curr Treat Options Oncol 2018 Mar 7;19(2):12.
    doi: 10.1007/s11864-018-0529-xpubmed: 29516275google scholar: lookup
  51. Beurlet S, Krief P, Sansonetti A, Briend-Marchal A, Kiladjian JJ, Padua RA, Chomienne C, Cassinat B. Identification of JAK2 mutations in canine primary polycythemia.. Exp Hematol 2011 May;39(5):542-5.
    doi: 10.1016/j.exphem.2011.02.003pubmed: 21320566google scholar: lookup
  52. Tefferi A. Annual Clinical Updates in Hematological Malignancies: a continuing medical education series: polycythemia vera and essential thrombocythemia: 2011 update on diagnosis, risk-stratification, and management.. Am J Hematol 2011 Mar;86(3):292-301.
    doi: 10.1002/ajh.21946pubmed: 21351120google scholar: lookup
  53. Chisholm-Chait A. Essential thrombocythemia in dogs and cats Part 1. Comp Cont Educ Vet 1999;21:158.
  54. Favier RP, van Leeuwen M, Teske E. Essential thrombocythaemia in two dogs. Comp Cont Educ Pract 1999;21:158–167.
  55. Stokol T. Essential thrombocythemia and reactive thrombocytosis. In: Weiss DJ, editor. Schalm's Veterinary Hematology. 6. Ames, Iowa: Blackwell; 2010. pp. 605–611.
  56. Hisasue M, Nishimura T, Neo S, Nagashima N, Ishikawa T, Tsuchiya R, Yamada T. A dog with acute myelomonocytic leukemia.. J Vet Med Sci 2008 Jun;70(6):619-21.
    doi: 10.1292/jvms.70.619pubmed: 18628605google scholar: lookup
  57. Hiraoka H, Hisasue M, Nagashima N, Miyama T, Tanimoto T, Watanabe M, Itamoto K, Mizuno T, Inokuma H, Okuda M. A dog with myelodysplastic syndrome: chronic myelomonocytic leukemia.. J Vet Med Sci 2007 Jun;69(6):665-8.
    doi: 10.1292/jvms.69.665pubmed: 17611368google scholar: lookup
  58. Marino CL, Tran JNSN, Stokol T. Atypical chronic myeloid leukemia in a German Shepherd Dog.. J Vet Diagn Invest 2017 May;29(3):338-345.
    doi: 10.1177/1040638716689581pubmed: 28205462google scholar: lookup
  59. Rossi G, Gelain ME, Foroni S, Comazzi S. Extreme monocytosis in a dog with chronic monocytic leukaemia.. Vet Rec 2009 Jul 11;165(2):54-6.
    doi: 10.1136/vetrec.165.2.54pubmed: 19596678google scholar: lookup
  60. Steinbach F, Stark R, Ibrahim S, Gawad EA, Ludwig H, Walter J, Commandeur U, Mauel S. Molecular cloning and characterization of markers and cytokines for equid myeloid cells.. Vet Immunol Immunopathol 2005 Oct 18;108(1-2):227-36.
    doi: 10.1016/j.vetimm.2005.07.015pubmed: 16112744google scholar: lookup

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