A study (1977-1992) of population dynamics of endoparasites featuring benzimidazole-resistant small strongyles (population S) in Shetland ponies.
Abstract: Critical tests (91) were done between 1977 and 1992 in Shetland ponies to evaluate drug susceptibility and population dynamics (present paper) of endoparasites. The test ponies, most less than 1 year old, were from a herd where older animals were treated every 8 weeks initially with cambendazole (CBZ) (1974-1978) and then with oxibendazole (OBZ) (1978-1992). Previous field test data (1974-1992) on older ponies in the breeding herd indicated the presence of benzimidazole (BZ) resistant small strongyles. Data on population dynamics from the present critical tests indicated that 28 species of small strongyles persisted over the study period in spite of initial susceptibility and later refractiveness of six species to both CBZ and OBZ. Changes in intensities and other aspects were observed for the six BZ-resistant species (Cyathostomum catinatium, Cyathostomum coronatum, Cylicocyclus nassatus, Cylicostephanus calicatus, Cylicostephanus goldi, and Cylicostephanus longibursatus). Variabilities, some striking, were found in prevalence and intensity in bots, stomach worms, ascarids, eyeworms, large strongyles, pinworms and tapeworms.
Publication Date: 1996-11-01 PubMed ID: 8988558DOI: 10.1016/s0304-4017(96)00998-3Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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The research article examines the population dynamics and drug susceptibility of endoparasites, specifically benzimidazole-resistant small strongyles, in Shetland ponies over a 15-year period (1977-1992).
Study Setup and Drug Treatment
- This study ran 91 tests between 1977 and 1992 on Shetland ponies, primarily focusing on ponies less than a year old.
- The test ponies were from a herd in which older animals were initially treated with the drug cambendazole (CBZ) every 8 weeks from 1974-1978. The drug treatment was then switched to oxibendazole (OBZ) from 1978-1992.
Observations of Benzimidazole (BZ) Resistant Small Strongyles
- Previous data from 1974-1992 on older ponies from the same breeding herd suggested the existence of benzimidazole (a type of antiparasitic medication) resistant small strongyles, which are a type of endoparasite.
- Detailed examination of data from this study confirmed the persistence of 28 species of small strongyles throughout the study period.
- Six specific species showed initial susceptibility to the drug treatments but eventually became resistant to both CBZ and OBZ. These species are: Cyathostomum catinatium, Cyathostomum coronatum, Cylicocyclus nassatus, Cylicostephanus calicatus, Cylicostephanus goldi, and Cylicostephanus longibursatus.
- Changes in prevalence and intensity of infection were observed for these six BZ-resistant species.
Variability in Other Parasitic Populations
- Besides small strongyles, the study also noted variations in frequency and intensity of infestation of other endoparasites such as bots, stomach worms, ascarids, eyeworms, large strongyles, pinworms, and tapeworms.
- These variabilities were described as ‘striking’, indicating significant changes or fluctuations in these parasitic populations during the course of the study.
Cite This Article
APA
Lyons ET, Tolliver SC, Drudge JH, Stamper S, Swerczek TW, Granstrom DE.
(1996).
A study (1977-1992) of population dynamics of endoparasites featuring benzimidazole-resistant small strongyles (population S) in Shetland ponies.
Vet Parasitol, 66(1-2), 75-86.
https://doi.org/10.1016/s0304-4017(96)00998-3 Publication
Researcher Affiliations
- Department of Veterinary Science, Gluck Equine Research Center, University of Kentucky, Lexington 40546-0099, USA.
MeSH Terms
- Animals
- Anthelmintics / pharmacology
- Anthelmintics / therapeutic use
- Benzimidazoles / pharmacology
- Benzimidazoles / therapeutic use
- Drug Resistance
- Horses
- Intestinal Diseases, Parasitic / drug therapy
- Intestinal Diseases, Parasitic / parasitology
- Intestinal Diseases, Parasitic / veterinary
- Population Dynamics
- Strongyle Infections, Equine / drug therapy
- Strongyle Infections, Equine / parasitology
- Strongyloidea / drug effects
- Strongyloidea / growth & development
Citations
This article has been cited 5 times.- Kuzmina TA, Königová A, Antipov A, Kuzmin Y, Kharchenko V, Syrota Y. Changes in equine strongylid communities after two decades of annual anthelmintic treatments at the farm level. Parasitol Res 2024 Nov 25;123(11):394.
- Kuzmina TA, Königová A, Burcáková L, Babjak M, Syrota Y. Strongylids of Domestic Horses in Eastern Slovakia: Species Diversity and Evaluation of Particular Factors Affecting Strongylid Communities. Acta Parasitol 2024 Jun;69(2):1284-1294.
- Kuzmina TA, Lyons ET, Tolliver SC, Dzeverin II, Kharchenko VA. Fecundity of various species of strongylids (Nematoda: Strongylidae)--parasites of domestic horses. Parasitol Res 2012 Dec;111(6):2265-71.
- Lyons ET, Kuzmina TA, Tolliver SC, Collins SS. Observations on development of natural infection and species composition of small strongyles in young equids in Kentucky. Parasitol Res 2011 Dec;109(6):1529-35.
- Lake SL, Matthews JB, Kaplan RM, Hodgkinson JE. Determination of genomic DNA sequences for beta-tubulin isotype 1 from multiple species of cyathostomin and detection of resistance alleles in third-stage larvae from horses with naturally acquired infections. Parasit Vectors 2009 Sep 25;2 Suppl 2(Suppl 2):S6.
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