A systematic review and meta-analysis of animal-type melanoma.
Abstract: Animal-type melanoma is a rare subtype of melanoma with heavily pigmented dermal epithelioid and spindled melanocytes. Its classification as a subtype of melanoma versus a borderline melanocytic tumor is debated. Objective: Our primary objective was to characterize the demographics, clinical presentation, histopathology, management, and outcomes of patients with animal-type melanoma. Methods: We performed a systematic review and meta-analysis of the English-language literature on animal-type melanoma. Results: We identified 190 cases of animal-type melanoma. They occurred equally in men and women, with Caucasians (53.7%) most commonly affected. The median Breslow depth was 3.8 mm; ulceration was reported present in 15.8%; and dermal mitoses greater than or equal to 1/mm(2) was reported in 27.4%. The most common initial management was wide local excision with sentinel lymph node biopsy (55.7%). In all, 78 patients underwent sentinel lymph node biopsy with 41.0% positivity rate. A total of 32 patients underwent completion lymph node dissection with 34.4% positivity rate. Locoregional recurrence was reported in 15 patients, recurrence with distant metastases in 6 patients, and death in 5 patients. Conclusions: Data were obtained from small studies with limited follow-up. There is no universally accepted definition of animal-type melanoma. Conclusions: Prospective studies with complete staging information and molecular profiling may allow further characterization of this tumor.
Copyright © 2015 American Academy of Dermatology, Inc. Published by Elsevier Inc. All rights reserved.
Publication Date: 2015-09-26 PubMed ID: 26412164DOI: 10.1016/j.jaad.2015.08.016Google Scholar: Lookup
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- Journal Article
- Meta-Analysis
- Research Support
- Non-U.S. Gov't
- Review
- Systematic Review
Summary
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The research article is a systematic review and meta-analysis on a rare subtype of melanoma called animal-type melanoma, studying its characteristics, management, and patient outcomes.
Objective and Methodology
- The key objective of this research was to discern the demographics, clinical presentation, histopathology, management, and outcomes of patients with animal-type melanoma. The ambiguity regarding whether to classify animal-type melanoma as a subtype of melanoma or a borderline melanocytic tumor has spurred this analysis.
- A systematic review and meta-analysis method was employed, focusing solely on English-language literature pertaining to animal-type melanoma.
Results
- A total of 190 cases of animal-type melanoma were analyzed, with an equal proportion of men and women affected. Caucasians were most commonly affected and represented 53.7% of cases.
- The median Breslow depth, a measurement illustrating the thickness of the melanoma, was 3.8mm. 15.8% of the cases showed ulceration, and dermal mitoses, a type of cell division, of 1 or more per mm² was reported in 27.4% of cases.
- The most prevalent initial management approach was wide local excision accompanied with a sentinel lymph node biopsy, chosen in 55.7% of the cases. 78 patients underwent this biopsy, with a 41.0% positivity rate. Additionally, 32 patients underwent a completion lymph node dissection with a positivity rate of 34.4%.
- The outcomes showed that 15 patients reported locoregional recurrence, 6 patients’ recurrence involved distant metastases, and 5 patients died.
Conclusions
- The data pulled for this retrospective research was primarily obtained from small studies that offer limited follow-up. It was noted that there is no universally accepted definition of animal-type melanoma.
- In conclusion, the paper recommends prospective studies with complete staging data and molecular profiling, which would enable a more comprehensive characterization of this tumor type and possibly lead to better treatment options and prognosis.
Cite This Article
APA
Vyas R, Keller JJ, Honda K, Cooper KD, Gerstenblith MR.
(2015).
A systematic review and meta-analysis of animal-type melanoma.
J Am Acad Dermatol, 73(6), 1031-1039.
https://doi.org/10.1016/j.jaad.2015.08.016 Publication
Researcher Affiliations
- Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
- Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
- Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
- Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
- Department of Dermatology, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. Electronic address: Meg.Gerstenblith@uhhospitals.org.
MeSH Terms
- Biopsy, Needle
- Female
- Humans
- Immunohistochemistry
- Incidence
- Male
- Melanocytes / pathology
- Melanoma / classification
- Melanoma / epidemiology
- Melanoma / pathology
- Prognosis
- Prospective Studies
- Rare Diseases
- Risk Assessment
- Skin Neoplasms / classification
- Skin Neoplasms / epidemiology
- Skin Neoplasms / pathology
Citations
This article has been cited 5 times.- Gedda V, González-Coloma F, Jeldres A, Rodríguez C, Coulon G, Castro A. Animal-type melanoma/pigmented epithelioid melanocytoma: three clinical cases of a rare and controversial entity.. An Bras Dermatol 2023 Nov-Dec;98(6):868-871.
- Bayraktar EC, Jour G. Pigmented Epithelioid Melanocytomas and Their Mimics; Focus on Their Novel Molecular Findings.. Biology (Basel) 2021 Dec 8;10(12).
- Moreau C, Le Touze A, Dujardin F, Maruani A. A Blue-pigmented Lesion on the Cheek in a Three-year-old Girl: A Quiz.. Acta Derm Venereol 2021 Oct 28;101(10):adv00580.
- Cazzato G, Arezzo F, Colagrande A, Cimmino A, Lettini T, Sablone S, Resta L, Ingravallo G. "Animal-Type Melanoma/Pigmented Epithelioid Melanocytoma": History and Features of a Controversial Entity.. Dermatopathology (Basel) 2021 Jul 5;8(3):271-276.
- Cabrera R, Recule F. Unusual Clinical Presentations of Malignant Melanoma: A Review of Clinical and Histologic Features with Special Emphasis on Dermatoscopic Findings.. Am J Clin Dermatol 2018 Nov;19(Suppl 1):15-23.
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