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Accuracy of low-field magnetic resonance imaging versus radiography for guiding injection of equine distal interphalangeal joint collateral ligaments.

Abstract: Desmopathy of the distal interphalangeal joint collateral ligament is a common cause of lameness in the horse and carries a variable prognosis for soundness. Intralesional treatment has been proposed for improving outcome; however, limited reports describe methods for injecting this ligament. The purpose of this study was to compare accuracy of low-field magnetic resonance imaging (MRI) vs. radiography for injecting the collateral ligament of the distal interphalangeal joint. Equine cadaver digit pairs (n = 10) were divided by random assignment to injection of the ligament by either technique. An observer unaware of injection technique determined injection success based on postinjection MRI and/or gross sections acquired from the proximal, middle, and distal portions of the ligament. McNemar's test was performed to determine statistical difference between injection techniques, the number of injection attempts, and injection of the medial or lateral collateral ligament. Magnetic resonance imaging guided injection was successful more frequently than radiographic-guided injection based on postinjection MRI (24 of 30 vs. 9 of 30; P = 0.0006) and gross sections (26 of 30 vs. 13 of 30; P = 0.0008). At each level of the ligament (proximal, middle, and distal), MRI-guided injection resulted in more successful injections than radiographic guidance. Statistical significance occurred at the proximal aspect of the collateral ligament based on postinjection MRI (P = 0.0143) and the middle portion of the ligament based on gross sections (P = 0.0253). Findings supported future testing of standing, low-field MRI as a technique for delivering intralesional regenerative therapy in live horses with desmopathy of these collateral ligaments.
Publication Date: 2013-09-17 PubMed ID: 24102665DOI: 10.1111/vru.12109Google Scholar: Lookup
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  • Comparative Study
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

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The article’s research focuses on comparing the accuracy of low-field magnetic resonance imaging (MRI) and radiography for injecting a compromised ligament in horses. The study concludes that MRI-guided injections were more successful than those guided by radiography.

Objective of the Research

  • The study’s primary goal was to assess the efficacy of two medical imaging techniques: low-field magnetic resonance imaging (MRI) and radiography, in guiding the injection of the collateral ligament of the distal interphalangeal joint in horses.
  • This assessment comes in response to limited reports describing effective methods for injecting this ligament, a common cause of lameness in horses, which varies considerably in terms of prognosis for recovery.

Methodology

  • The study used equine cadaver digit pairs randomly assigned to injection of the ligament by either MRI or radiography.
  • An observer, uninformed about the injection technique used, was tasked to determine the success of the injection using postinjection MRI or by examining gross sections from the ligament’s proximal, middle, and distal portions.
  • The McNemar’s test was used to determine any statistically significant difference between the injection techniques, number of injection attempts, and targeting either the medial or lateral collateral ligament.

Results

  • Compared to radiographic-guided injections, MRI-guided injections were more often successful, based both on postinjection MRI readings and gross section examinations.
  • Regardless of the ligament level (proximal, middle, distal), MRI-guided injections resulted in more successful instances than those guided by radiography.
  • The difference in success rate was statistically significant at the proximal part of the ligament when analysing postinjection MRI data and at the middle portion when looking at gross sections.

Conclusion and Implications

  • Findings from this study support further research into using standing, low-field MRI as a technique for delivering intralesional regenerative therapy in live horses exhibiting desmopathy of these collateral ligaments.

Cite This Article

APA
Lamb MM, Barrett JG, White NA, Werre SR. (2013). Accuracy of low-field magnetic resonance imaging versus radiography for guiding injection of equine distal interphalangeal joint collateral ligaments. Vet Radiol Ultrasound, 55(2), 174-181. https://doi.org/10.1111/vru.12109

Publication

ISSN: 1740-8261
NlmUniqueID: 9209635
Country: England
Language: English
Volume: 55
Issue: 2
Pages: 174-181

Researcher Affiliations

Lamb, Megan M
  • Marion duPont Scott Equine Medical Center, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech University, VA, 24601.
Barrett, Jennifer G
    White, Nathaniel A
      Werre, Stephen R

        MeSH Terms

        • Animals
        • Collateral Ligaments / pathology
        • Foot Diseases / therapy
        • Foot Diseases / veterinary
        • Forelimb / pathology
        • Horse Diseases / therapy
        • Horses
        • Injections, Intra-Articular / veterinary
        • Lameness, Animal / therapy
        • Magnetic Resonance Imaging / standards
        • Magnetic Resonance Imaging / veterinary
        • Radiography / standards
        • Radiography / veterinary
        • Toe Joint / pathology

        Citations

        This article has been cited 1 times.
        1. White NA 2nd, Barrett JG. Magnetic Resonance Imaging-Guided Treatment of Equine Distal Interphalangeal Joint Collateral Ligaments: 2009-2014. Front Vet Sci 2016;3:73.
          doi: 10.3389/fvets.2016.00073pubmed: 27656645google scholar: lookup