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Home / Equine Research Bank / Inflamm Res / Actions of PAF receptor antagonists in horses with the aller...
Inflammation research : official journal of the European Histamine Research Society ... [et al.]1995; 44(10); 412-417; doi: 10.1007/BF01757697

Actions of PAF receptor antagonists in horses with the allergic skin disease sweet itch.

Abstract: Platelet activating factor (PAF) mimics the effects of Culicoides antigen by inducing oedema and inflammatory cell accumulation in the dermis of horses with the allergic skin disease, sweet itch. PAF could therefore contribute to antigen-induced inflammatory changes in these horses. We now report that intravenous administration of the PAF receptor antagonist WEB 2086 (3 mg kg-1), at a dose that inhibited the vascular and cellular responses to PAF in sweet itch horses, reduced Culicoides antigen-induced oedema at 1 h by 73% and at 8 h by 71% (p < 0.05). Neutrophil accumulation and eosinophil recruitment were not significantly reduced by WEB 2086 or a second hetrazepine PAF receptor antagonist WEB 2170 (0.1 mg kg-1). These findings suggest a key role for PAF in oedema formation, but not inflammatory cell accumulation, induced by Culicoides antigen in the skin of sweet itch horses.
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Publication Date: 1995-10-01 PubMed ID: 8564516DOI: 10.1007/BF01757697Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The study reports on how platelet activating factor (PAF) contributes to the allergic skin disease sweet itch in horses. By using PAF receptor antagonists, the researchers could significantly reduce swelling caused by the disease, but found no significant change in the accumulation of inflammatory cells.

Research Goal and Rationale

  • The aim of this study was to investigate the role of platelet activating factor (PAF) in inducing inflammatory responses in horses that suffer from sweet itch, a common allergic skin disease caused by the Culicoides antigen. The researchers also aimed to establish if PAF receptor antagonists could be used to inhibit these responses and provide a possible therapeutic intervention.

Methodology

  • The researchers utilized PAF, which mimics the effects of the Culicoides antigen causing inflammation and swelling. They also employed the use of PAF receptor antagonists, specifically WEB 2086 and WEB 2170. These were administered intravenously to horses suffering from sweet itch.
  • A key process of the methodology was measuring the response of the horses to the PAF and the PAF receptor antagonists, observing both edema (swelling) and inflammatory cell accumulation.

Findings

  • Results demonstrated that administration of the PAF receptor antagonist WEB 2086 significantly reduced Culicoides antigen-induced swelling by approximately 73% at 1 hour and 71% at 8 hours. These results were statistically significant (p<0.05).
  • However, the neutrophil accumulation and eosinophil recruitment – both indicators of inflammation – were not significantly reduced by either WEB 2086 or the second antagonist, WEB 2170.

Conclusion

  • The study concluded that PAF plays a crucial role in inducing edema formation in horses suffering from sweet itch. However, the accumulation of inflammatory cells was not significantly affected by antagonists of the PAF receptor.
  • This suggests that while PAF receptor antagonists might aid in reducing swelling in horses with sweet itch, a comprehensive understanding of managing the inflammatory response requires further research.

Cite This Article

APA
Foster AP, Lees P, Cunningham FM. (1995). Actions of PAF receptor antagonists in horses with the allergic skin disease sweet itch. Inflamm Res, 44(10), 412-417. https://doi.org/10.1007/BF01757697

Publication

Inflammation research : official journal of the European Histamine Research Society ... [et al.]
ISSN: 1023-3830
NlmUniqueID: 9508160
Country: Switzerland
Language: English
Volume: 44
Issue: 10
Pages: 412-417

Researcher Affiliations

Foster, A P
  • Department of Veterinary Basic Sciences, Royal Veterinary College, Hatfield, Hertfordshire, UK.
Lees, P
    Cunningham, F M

      MeSH Terms

      • Animals
      • Azepines / administration & dosage
      • Azepines / therapeutic use
      • Ceratopogonidae / immunology
      • Dermatitis, Allergic Contact / drug therapy
      • Dermatitis, Allergic Contact / immunology
      • Dermatitis, Allergic Contact / veterinary
      • Edema / drug therapy
      • Edema / immunology
      • Edema / veterinary
      • Female
      • Horse Diseases / drug therapy
      • Horse Diseases / immunology
      • Horses / physiology
      • Injections, Intradermal
      • Injections, Intravenous
      • Insect Bites and Stings / immunology
      • Insect Bites and Stings / veterinary
      • Male
      • Platelet Aggregation Inhibitors / administration & dosage
      • Platelet Aggregation Inhibitors / therapeutic use
      • Platelet Membrane Glycoproteins / antagonists & inhibitors
      • Pruritus / drug therapy
      • Pruritus / immunology
      • Pruritus / veterinary
      • Receptors, Cell Surface
      • Receptors, G-Protein-Coupled
      • Triazoles / administration & dosage
      • Triazoles / therapeutic use

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      Citations

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