Acute kidney injury mediated by oxidative stress in Egyptian horses with exertional rhabdomyolysis.
Abstract: The present study was carried out to evaluate the role of oxidative stress in the pathophysiologic process of acute renal failure associated with exertional rhabdomyolysis (ER) in Egyptian horses. ER was tentatively diagnosed in 31 Baladi horses based on case history, physical examination findings and confirmed by elevation of plasma creatine kinase (CK) and urine myoglobin concentrations. According to severity of the condition, the diseased horses were categorized into two main groups; the first group included 18 horses with minimal clinical signs and plasma CK <60 000 IU/L; whereas, the second group included 13 horses with overt clinical signs and plasma CK >100 000 IU/L). It was found that plasma creatol (CTL) was positively correlated (p < 0.01) with plasma malondialdehyde (MDA) (r = 0.775), nitric oxide (NO) (r = 0.768), methyguanididne (MG) (r = 0.995), CK (r = 0.768), urine glucose (r = 0.778), urine protein (r = 0.767), renal failure index (RFI) (r = 0.814) and urine sodium (r = 0.799) and negatively correlated (p < 0.01) with total antioxidant capacity (TAC) (r = -0.795), superoxide dismutase (SOD) (r = -0.815), glutathione peroxidase (GSH-Px) (r = -0.675), Vitamin C (r = -0.830), urine creatinine (r = -0.800), urine/plasma creatinine ratio (r = -0.827) and urine/plasma urea ratio (r = -0.807). The correlation between these biochemical variables might suggest a possible role of oxidative stress in renal injury associated with severe rhabdomyolysis in horses. It is suggested that exaggeration of oxidative stress associated with increased muscle membrane leakage plays a key role in acute kidney injury in Baladi horses with severe rhabdomyolysis.
Publication Date: 2011-04-02 PubMed ID: 21461642DOI: 10.1007/s11259-011-9475-9Google Scholar: Lookup
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- Journal Article
- Antioxidants
- Biochemistry
- Clinical Examination
- Clinical Findings
- Correlation Analysis
- Creatine Kinase
- Creatinine
- Diagnosis
- Disease Diagnosis
- Equine Health
- Glutathione
- Horses
- Kidneys
- Nitric Oxide
- Oxidative Stress
- Pathophysiology
- Recurrent Exertional Rhabdomyolysis
- Renal Health
- Urine Analysis
- Veterinary Medicine
- Vitamin C
Summary
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This research paper aims to investigate the role of oxidative stress in causing acute kidney injury in Egyptian horses suffering from exertional rhabdomyolysis. The study found a correlation between certain biochemical variables and severity of the disease, suggesting oxidative stress plays a significant part in kidney injury associated with the condition.
Introduction to the Study
- The study was conducted to understand the role of oxidative stress in the occurrence of acute kidney failure in Egyptian horses afflicted with exertional rhabdomyolysis (ER).
- Exertional rhabdomyolysis is a condition in horses where muscle damage happens due to intense excercise, leading to release of by-products into the bloodstream that can harm the kidneys.
Methodology of the Study
- The study observed 31 Egyptian Baladi horses diagnosed with ER based on their medical history, physical examination, and elevated levels of plasma creatine kinase (CK) and urine myoglobin.
- The horses were divided into two groups based on the severity of their conditions: one with mild signs and plasma CK less than 60,000 IU/L and the other with obvious signs and plasma CK greater than 100,000 IU/L.
Findings of the Study
- The study revealed that plasma creatol (CTL), a waste product of muscle tissue breakdown, is significantly positively correlated with other plasma components, such as malondialdehyde (MDA), nitric oxide (NO), methyguanididne (MG), and CK. This indicates an increase in CTL corresponded with an increase in these markers.
- This increase was also extended to urine glucose, urine protein, renal failure index (RFI), and urine sodium. The elevated levels potentially suggest kidney damage and failure.
- Conversely, a negative correlation was found with total antioxidant capacity (TAC), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), Vitamin C, urine creatinine, urine/plasma creatinine ratio, and urine/plasma urea ratio, indicating that as CTL levels increase, these antioxidant and renal efficiency markers decrease.
Conclusion of the Study
- The study suggests that an increase in oxidative stress, related to muscle tissue breakdown, plays a significant role in acute kidney injury in horses suffering from exertional rhabdomyolysis.
- The findings highlight potential biochemical markers for assessing the severity of ER in horses and underline the need for treatment methods to manage oxidative stress in these animals to prevent kidney damage.
Cite This Article
APA
el-Ashker MR.
(2011).
Acute kidney injury mediated by oxidative stress in Egyptian horses with exertional rhabdomyolysis.
Vet Res Commun, 35(5), 311-320.
https://doi.org/10.1007/s11259-011-9475-9 Publication
Researcher Affiliations
- Department of Internal Medicine and Infectious Diseases, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516, Egypt. maged_elashker@yahoo.com
MeSH Terms
- Acute Kidney Injury / etiology
- Acute Kidney Injury / veterinary
- Animals
- Biomarkers / blood
- Biomarkers / urine
- Blood Chemical Analysis / veterinary
- Egypt
- Female
- Horse Diseases / physiopathology
- Horses
- Male
- Oxidative Stress
- Rhabdomyolysis / complications
- Rhabdomyolysis / physiopathology
- Rhabdomyolysis / veterinary
- Urinalysis / veterinary
References
This article includes 19 references
- J Am Soc Nephrol. 2000 Aug;11(8):1553-1561
- Can Vet J. 1998 Aug;39(8):500-3
- J Nutr. 2002 Jun;132(6 Suppl 2):1781S-3S
- Ren Fail. 2007;29(3):279-83
- J Am Vet Med Assoc. 1982 Feb 1;180(3):284-8
- Vet Res Commun. 1995;19(3):179-84
- Free Radic Biol Med. 1999 Dec;27(11-12):1173-81
- J Anim Sci. 2004 Feb;82(2):588-94
- J Sports Sci Med. 2005 Dec 01;4(4):415-21
- Ann N Y Acad Sci. 2005 Dec;1066:166-80
- J Clin Pathol. 2001 May;54(5):356-61
- Vet Res Commun. 2010 Dec;34(8):677-89
- J Vet Med Sci. 1991 Dec;53(6):1001-7
- Sports Med. 1990 Oct;10(4):236-54
- Nihon Juigaku Zasshi. 1990 Aug;52(4):759-65
- Nephron. 1994;66(2):140-6
- Eur J Appl Physiol Occup Physiol. 1996;74(1-2):60-6
- Biochim Biophys Acta. 2009 Aug;1792(8):796-803
- Vet Clin Pathol. 2001;30(4):214-218
Citations
This article has been cited 2 times.- Siwinska N, Zak A, Slowikowska M, Niedzwiedz A, Paslawska U. Serum symmetric dimethylarginine concentration in healthy horses and horses with acute kidney injury. BMC Vet Res 2020 Oct 20;16(1):396.
- Kouadio JH, Moukha S, Brou K, Gnakri D. Lipid metabolism disorders, lymphocytes cells death, and renal toxicity induced by very low levels of deoxynivalenol and fumonisin b1 alone or in combination following 7 days oral administration to mice. Toxicol Int 2013 Sep;20(3):218-23.
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