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Home / Equine Research Bank / Can Vet J / Acute myeloid leukemia with basophilic differentiation in a ...
The Canadian veterinary journal = La revue veterinaire canadienne2016; 57(10); 1067-1071;

Acute myeloid leukemia with basophilic differentiation in a 3-year-old Standardbred gelding.

Abstract: A 3-year-old Standardbred gelding with a history of pyrexia, persistent hemorrhage from the oral cavity, and a large, soft swelling at the junction of the caudal aspect of the mandibular rami and proximal neck was evaluated. The horse had neutropenia and anemia, with atypical granulated cells in a blood smear. Additional tests confirmed acute myeloid leukemia with basophilic differentiation, which has been reported in humans, cats, dogs, and cattle but not horses. Nous avons évalué un hongre Standardbred âgé de 3 ans avec une anamnèse de pyrexie, d’hémorragie persistante de la cavité orale et d’une grosse enflure molle à la jonction de l’aspect caudal des rameaux mandibulaires et du cou proximal. Le cheval souffrait de neutropénie et d’anémie avec des cellules granulées au frottis sanguin. Des tests additionnels ont confirmé une leucémie myéloïde avec différenciation basophile, qui avait déjà été signalée chez les humains, les chats, les chiens et le bétail, mais pas chez les chevaux.(Traduit par Isabelle Vallières).
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Publication Date: 2016-10-07 PubMed ID: 27708445PubMed Central: PMC5026147
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research paper discusses a case of a 3-year-old Standardbred gelding horse diagnosed with acute myeloid leukemia with basophilic differentiation, a condition never reported in horses before.

Health History and Sypmtoms

  • The 3-year-old Standardbred gelding horse had a history of pyrexia (fever), incessant bleeding from the oral cavity, and a substantial, soft swelling at the junction of the rear side of the mandibular rami (lower jawbone) and proximal neck.
  • The observed symptoms and ailments of the horse led to its evaluation by the researchers.

Diagnostic Findings

  • Upon further examination, it was found that the horse was suffering from neutropenia (a condition characterized by low count of neutrophils, a type of white blood cell) and anemia (a condition marked by a deficiency of red blood cells).
  • An analysis of a blood smear test showed the presence of atypical granulated cells, a characteristic often associated with various forms of leukemia.

Additional Tests and Results

  • Further tests were carried out to identify and confirm the specific type of leukemia.
  • The results confirmed that the horse was suffering from acute myeloid leukemia with basophilic differentiation, a rare subtype of acute myeloid leukemia that represents the blood cells known as basophils.

Significance of the Findings

  • What stood out in this case is that acute myeloid leukemia with basophilic differentiation has been previously reported in humans, cats, dogs, and cattle, but this was the first reported case in horses.
  • The findings are significant because they document a new manifestation of a known disease in a different species, thereby expanding our understanding of the disease spectrum across diverse species.

Cite This Article

APA
Furness MC, Setlakwe E, Sallaway J, Wood D, Fromstein J, Arroyo LG. (2016). Acute myeloid leukemia with basophilic differentiation in a 3-year-old Standardbred gelding. Can Vet J, 57(10), 1067-1071.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 57
Issue: 10
Pages: 1067-1071

Researcher Affiliations

Furness, Mary Catherine
  • Department of Clinical Studies (Furness, Setlakwe, Arroyo) and Department of Pathobiology (Wood, Fromstein), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1; Dr. John Sallaway Mobile Equine Services, 1532 Chemong Road, Peterborough, Ontario K9J 6X2 (Sallaway).
Setlakwe, Emile
  • Department of Clinical Studies (Furness, Setlakwe, Arroyo) and Department of Pathobiology (Wood, Fromstein), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1; Dr. John Sallaway Mobile Equine Services, 1532 Chemong Road, Peterborough, Ontario K9J 6X2 (Sallaway).
Sallaway, John
  • Department of Clinical Studies (Furness, Setlakwe, Arroyo) and Department of Pathobiology (Wood, Fromstein), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1; Dr. John Sallaway Mobile Equine Services, 1532 Chemong Road, Peterborough, Ontario K9J 6X2 (Sallaway).
Wood, Darren
  • Department of Clinical Studies (Furness, Setlakwe, Arroyo) and Department of Pathobiology (Wood, Fromstein), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1; Dr. John Sallaway Mobile Equine Services, 1532 Chemong Road, Peterborough, Ontario K9J 6X2 (Sallaway).
Fromstein, Jordan
  • Department of Clinical Studies (Furness, Setlakwe, Arroyo) and Department of Pathobiology (Wood, Fromstein), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1; Dr. John Sallaway Mobile Equine Services, 1532 Chemong Road, Peterborough, Ontario K9J 6X2 (Sallaway).
Arroyo, Luis G
  • Department of Clinical Studies (Furness, Setlakwe, Arroyo) and Department of Pathobiology (Wood, Fromstein), Ontario Veterinary College, University of Guelph, Guelph, Ontario N1G 2W1; Dr. John Sallaway Mobile Equine Services, 1532 Chemong Road, Peterborough, Ontario K9J 6X2 (Sallaway).

MeSH Terms

  • Animals
  • Disseminated Intravascular Coagulation / diagnosis
  • Disseminated Intravascular Coagulation / etiology
  • Disseminated Intravascular Coagulation / pathology
  • Disseminated Intravascular Coagulation / veterinary
  • Hemorrhage / veterinary
  • Horse Diseases / diagnosis
  • Horse Diseases / etiology
  • Horse Diseases / pathology
  • Horses
  • Leukemia, Myeloid, Acute / complications
  • Leukemia, Myeloid, Acute / diagnosis
  • Leukemia, Myeloid, Acute / pathology
  • Leukemia, Myeloid, Acute / veterinary
  • Male

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Citations

This article has been cited 2 times.
  1. Shimoda T, Tanabe M, Shoji Y, Kanda T, Kishida K, Kishida A, Hashimoto A, Otsuka M, Miyamoto A, Kawakita T, Oshita W, Hirao R, Suwa A. Monoblastic leukemia (M5a) with chronic basophilic leukemia in a cat.. J Vet Med Sci 2022 Feb 23;84(2):251-256.
    doi: 10.1292/jvms.21-0383pubmed: 34911870google scholar: lookup
  2. Satué K, Gardon JC, Muñoz A. A review of current knowledge of myeloproliferative disorders in the horse.. Acta Vet Scand 2021 Feb 23;63(1):8.
    doi: 10.1186/s13028-021-00573-3pubmed: 33622355google scholar: lookup
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