Acute myonecrosis in horse caused by Clostridium novyi type A.
Abstract: The objective of this study was to describe the first report involving a case of equine acute myonecrosis caused by C. novyi type A with an emphasis on clinical signs, the pathological and bacteriological analysis, and molecular identification of the microorganisms as the key of the definitive diagnosis.
Publication Date: 2014-04-08 PubMed ID: 24948935PubMed Central: PMC4059300DOI: 10.1590/S1517-83822014005000023Google Scholar: Lookup
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Summary
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The research aimed to examine a unique case of equine acute myonecrosis caused by the bacterium Clostridium novyi type A, focusing on aspects such as clinical signs, pathology, bacteriology, and molecular identification.
Objective Overview
This study documents the first reported instance of acute myonecrosis, a severe muscle condition, in a horse caused by Clostridium novyi type A bacteria. The investigation centered around the clinical signs, pathological and bacteriological analyses, and molecular identification for a definitive diagnosis.
Detailed Explanation
Study Focus
- The research was centered on a single unique case of equine acute myonecrosis, providing an in-depth study of this condition in relation to its causative agent, Clostridium novyi type A.
- Acute myonecrosis denotes a severe and sudden muscle tissue injury, which in this case, was observed in a horse.
- This study represents the first document of its kind outlining this particular pathology being attributed to a C. novyi type A infection in horses.
Clinical Signs
- The researchers highlighted the clinical signs observed in the horse indicating an infection with C. novyi type A.
- These could potentially guide veterinary clinicians on symptomatology to look for when diagnosing similar cases in the future.
Pathological and Bacteriological Analysis
- The study involved detailed pathological and bacteriological analyses.
- The pathology contributed to understand how the disease was affecting the horse’s body, specifically the muscle tissues.
- The bacteriological analysis identified the causative agent of the condition as Clostridium novyi type A. This bacterial species is known to produce potent toxins, which likely contributed to the acute muscle damage observed.
Molecular Identification
- Finally, the research used molecular identification methods to definitively diagnose the infection with C. novyi type A.
- This involved the use of genetic techniques to specify the exact bacterial strain responsible for the horse’s condition.
- This level of identification is vital for both confirming the diagnosis and informing potential treatment strategies.
Cite This Article
APA
Farias LD, Azevedo Mda S, Trost ME, De La Côrte FD, Irigoyen LF, de Vargas AC.
(2014).
Acute myonecrosis in horse caused by Clostridium novyi type A.
Braz J Microbiol, 45(1), 221-224.
https://doi.org/10.1590/S1517-83822014005000023 Publication
Researcher Affiliations
- Departamento de Medicina Veterinária Preventiva Universidade Federal de Santa Maria Santa MariaRS Brazil.
- Departamento de Clínica de Grandes Animais Universidade Federal de Santa Maria Santa MariaRS Brazil.
- Laboratório de Patologia Veterinária Universidade Federal de Santa Maria Santa MariaRS Brazil.
- Departamento de Clínica de Grandes Animais Universidade Federal de Santa Maria Santa MariaRS Brazil.
- Laboratório de Patologia Veterinária Universidade Federal de Santa Maria Santa MariaRS Brazil.
- Departamento de Medicina Veterinária Preventiva Universidade Federal de Santa Maria Santa MariaRS Brazil.
MeSH Terms
- Animals
- Clostridium / classification
- Clostridium / isolation & purification
- Clostridium Infections / diagnosis
- Clostridium Infections / microbiology
- Clostridium Infections / pathology
- Clostridium Infections / veterinary
- Cluster Analysis
- DNA, Bacterial / chemistry
- DNA, Bacterial / genetics
- DNA, Ribosomal / chemistry
- DNA, Ribosomal / genetics
- Histocytochemistry
- Horse Diseases / diagnosis
- Horse Diseases / microbiology
- Horse Diseases / pathology
- Horses
- Myositis / diagnosis
- Myositis / microbiology
- Myositis / pathology
- Myositis / veterinary
- Necrosis / diagnosis
- Necrosis / microbiology
- Necrosis / pathology
- Necrosis / veterinary
- Phylogeny
- RNA, Ribosomal, 16S / genetics
- Sequence Analysis, DNA
References
This article includes 23 references
- Aleman M, Watson JL, Jang SS. Clostridium novyi type A intra-abdominal abscess in a horse.. J Vet Intern Med 2003 Nov-Dec;17(6):934-6.
- Amimoto K, Sasaki O, Isogai M, Kitajima T, Oishi E, Okada N, Yasuhara H. The protective effect of Clostridium novyi type B alpha-toxoid against challenge with spores in guinea pigs.. J Vet Med Sci 1998 Jun;60(6):681-5.
- Breuhaus BA, Brown CM, Scott EA, Ainsworth DM, Taylor RF. Clostridial muscle infections following intramuscular injections in the horse.. J Equine Vet Sci 1983;3:42–46.
- Brown CM, Kaneene JB, Walker RD. Intramuscular injection techniques and the development of clostridial myositis or cellulitis in horses.. J Am Vet Med Assoc 1988 Sep 15;193(6):668-70.
- Choi YK, Kang MS, Yoo HS, Lee DY, Lee HC, Kim DY. Clostridium perfringens type A myonecrosis in a horse in Korea.. J Vet Med Sci 2003 Nov;65(11):1245-7.
- Collins MD, Lawson PA, Willems A, Cordoba JJ, Fernandez-Garayzabal J, Garcia P, Cai J, Hippe H, Farrow JA. The phylogeny of the genus Clostridium: proposal of five new genera and eleven new species combinations.. Int J Syst Bacteriol 1994 Oct;44(4):812-26.
- Coloe PJ, Ireland L, Vaudrey JC. Clostridium fallax as a cause of gas-oedema disease in a horse.. J Comp Pathol 1983 Oct;93(4):597-601.
- Dumaresq J. A case of black disease in the horse.. Aust Vet J 1939;15:53–57.
- Gay CC, Lording PM, McNeil P, Richards WP. Infectious necrotic hepatitis (black disease) in a horse.. Equine Vet J 1980 Jan;12(1):26-7.
- Graham R. Reactions in horses following inoculation of a chick-embryo vaccine.. J Am Vet Assoc 1940;97:38–39.
- Hagemoser WA, Hoffman LJ, Lundvall RL. Clostridium chauvoei infection in a horse.. J Am Vet Med Assoc 1980 Apr 1;176(7):631-3.
- Harwood DG. Apparent iatrogenic clostridial myositis in cattle.. Vet Rec 1984 Oct 20;115(16):412.
- Hollingsworth TC, Green VJ. Focal necrotising hepatitis caused by Clostridium novyi in a horse.. Aust Vet J 1978 Jan;54(1):48.
- McGUIGAN CC, Penrice GM, Gruer L, Ahmed S, Goldberg D, Black M, Salmon JE, Hood J. Lethal outbreak of infection with Clostridium novyi type A and other spore-forming organisms in Scottish injecting drug users.. J Med Microbiol 2002 Nov;51(11):971-977.
- Oaks JL, Kanaly ST, Fisher TJ, Besser TE. Apparent Clostridium haemolyticum/Clostridium novyi infection and exotoxemia in two horses.. J Vet Diagn Invest 1997 Jul;9(3):324-5.
- Peek SF, Semrad SD, Perkins GA. Clostridial myonecrosis in horses (37 cases 1985-2000).. Equine Vet J 2003 Jan;35(1):86-92.
- Raymundo DL, Pavarini SP, Bezerra PS, Antoniassi NAB, Bandarra PM, Bercht BS, Gomes MJP, Driemeier D. Mionecrose aguda por Clostridium septicum em eqüinos.. Pesq Vet Bras 2010;30:637–640.
- Rebhun WC, Shin SJ, King JM, Baum KH, Patten V. Malignant edema in horses.. J Am Vet Med Assoc 1985 Oct 1;187(7):732-6.
- Sasaki Y, Takikawa N, Kojima A, Norimatsu M, Suzuki S, Tamura Y. Phylogenetic positions of Clostridium novyi and Clostridium haemolyticum based on 16S rDNA sequences.. Int J Syst Evol Microbiol 2001 May;51(Pt 3):901-904.
- Songer JG. Histotoxic clostridia.. In: Gyles CL, Prescott JF, Songer G, Thoen CO, editors. Pathogenesis of Bacterial Infections in Animals. 4th ed. Blackwell Publishing; Ames: 2010. pp. 203–209.
- Valberg SJ, McKinnon AO. Clostridial cellulitis in the horse: a report of five cases.. Can Vet J 1984 Feb;25(2):67-71.
- Vengust M, Arroyo LG, Weese JS, Baird JD. Preliminary evidence for dormant clostridial spores in equine skeletal muscle.. Equine Vet J 2003 Jul;35(5):514-6.
- Walker PD. Clostridium.. In: Carter GR, Cole JR, editors. Diagnostic Procedures in Veterinary Bacteriology and Mycology. 5th ed. Academic Press; New York: 1990. pp. 229–251.
Citations
This article has been cited 4 times.- Uzal FA, Navarro MA, Asin J, Henderson EE. Clostridial Diseases of Horses: A Review.. Vaccines (Basel) 2022 Feb 17;10(2).
- Junior CAO, Silva ROS, Lobato FCF, Navarro MA, Uzal FA. Gas gangrene in mammals: a review.. J Vet Diagn Invest 2020 Mar;32(2):175-183.
- Zaragoza NE, Orellana CA, Moonen GA, Moutafis G, Marcellin E. Vaccine Production to Protect Animals Against Pathogenic Clostridia.. Toxins (Basel) 2019 Sep 11;11(9).
- Salari Sedigh H, Rajabioun M, Razmyar J, Kazemi Mehrjerdi H. An unusual necrotic myositis by Clostridium perfringens in a German Shepherd dog: A clinical report, bacteriological and molecular identification.. Vet Res Forum 2015 Fall;6(4):349-53.
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