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Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2014; 45(1); 221-224; doi: 10.1590/S1517-83822014005000023

Acute myonecrosis in horse caused by Clostridium novyi type A.

Abstract: The objective of this study was to describe the first report involving a case of equine acute myonecrosis caused by C. novyi type A with an emphasis on clinical signs, the pathological and bacteriological analysis, and molecular identification of the microorganisms as the key of the definitive diagnosis.
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Publication Date: 2014-04-08 PubMed ID: 24948935PubMed Central: PMC4059300DOI: 10.1590/S1517-83822014005000023Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research aimed to examine a unique case of equine acute myonecrosis caused by the bacterium Clostridium novyi type A, focusing on aspects such as clinical signs, pathology, bacteriology, and molecular identification.

Objective Overview

This study documents the first reported instance of acute myonecrosis, a severe muscle condition, in a horse caused by Clostridium novyi type A bacteria. The investigation centered around the clinical signs, pathological and bacteriological analyses, and molecular identification for a definitive diagnosis.

Detailed Explanation

Study Focus

  • The research was centered on a single unique case of equine acute myonecrosis, providing an in-depth study of this condition in relation to its causative agent, Clostridium novyi type A.
  • Acute myonecrosis denotes a severe and sudden muscle tissue injury, which in this case, was observed in a horse.
  • This study represents the first document of its kind outlining this particular pathology being attributed to a C. novyi type A infection in horses.

Clinical Signs

  • The researchers highlighted the clinical signs observed in the horse indicating an infection with C. novyi type A.
  • These could potentially guide veterinary clinicians on symptomatology to look for when diagnosing similar cases in the future.

Pathological and Bacteriological Analysis

  • The study involved detailed pathological and bacteriological analyses.
  • The pathology contributed to understand how the disease was affecting the horse’s body, specifically the muscle tissues.
  • The bacteriological analysis identified the causative agent of the condition as Clostridium novyi type A. This bacterial species is known to produce potent toxins, which likely contributed to the acute muscle damage observed.

Molecular Identification

  • Finally, the research used molecular identification methods to definitively diagnose the infection with C. novyi type A.
  • This involved the use of genetic techniques to specify the exact bacterial strain responsible for the horse’s condition.
  • This level of identification is vital for both confirming the diagnosis and informing potential treatment strategies.

Cite This Article

APA
Farias LD, Azevedo Mda S, Trost ME, De La Côrte FD, Irigoyen LF, de Vargas AC. (2014). Acute myonecrosis in horse caused by Clostridium novyi type A. Braz J Microbiol, 45(1), 221-224. https://doi.org/10.1590/S1517-83822014005000023

Publication

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
ISSN: 1678-4405
NlmUniqueID: 101095924
Country: Brazil
Language: English
Volume: 45
Issue: 1
Pages: 221-224

Researcher Affiliations

Farias, Luana D'avila
  • Departamento de Medicina Veterinária Preventiva Universidade Federal de Santa Maria Santa MariaRS Brazil.
Azevedo, Marcos Da Silva
  • Departamento de Clínica de Grandes Animais Universidade Federal de Santa Maria Santa MariaRS Brazil.
Trost, Maria Elisa
  • Laboratório de Patologia Veterinária Universidade Federal de Santa Maria Santa MariaRS Brazil.
De La Côrte, Flávio Desessards
  • Departamento de Clínica de Grandes Animais Universidade Federal de Santa Maria Santa MariaRS Brazil.
Irigoyen, Luiz Francisco
  • Laboratório de Patologia Veterinária Universidade Federal de Santa Maria Santa MariaRS Brazil.
de Vargas, Agueda Castagna
  • Departamento de Medicina Veterinária Preventiva Universidade Federal de Santa Maria Santa MariaRS Brazil.

MeSH Terms

  • Animals
  • Clostridium / classification
  • Clostridium / isolation & purification
  • Clostridium Infections / diagnosis
  • Clostridium Infections / microbiology
  • Clostridium Infections / pathology
  • Clostridium Infections / veterinary
  • Cluster Analysis
  • DNA, Bacterial / chemistry
  • DNA, Bacterial / genetics
  • DNA, Ribosomal / chemistry
  • DNA, Ribosomal / genetics
  • Histocytochemistry
  • Horse Diseases / diagnosis
  • Horse Diseases / microbiology
  • Horse Diseases / pathology
  • Horses
  • Myositis / diagnosis
  • Myositis / microbiology
  • Myositis / pathology
  • Myositis / veterinary
  • Necrosis / diagnosis
  • Necrosis / microbiology
  • Necrosis / pathology
  • Necrosis / veterinary
  • Phylogeny
  • RNA, Ribosomal, 16S / genetics
  • Sequence Analysis, DNA

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This article includes 23 references
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Citations

This article has been cited 6 times.
  1. Uzal FA, Navarro MA, Asin J, Henderson EE. Clostridial Diseases of Horses: A Review. Vaccines (Basel) 2022 Feb 17;10(2).
    doi: 10.3390/vaccines10020318pubmed: 35214776google scholar: lookup
  2. Junior CAO, Silva ROS, Lobato FCF, Navarro MA, Uzal FA. Gas gangrene in mammals: a review. J Vet Diagn Invest 2020 Mar;32(2):175-183.
    doi: 10.1177/1040638720905830pubmed: 32081096google scholar: lookup
  3. Zaragoza NE, Orellana CA, Moonen GA, Moutafis G, Marcellin E. Vaccine Production to Protect Animals Against Pathogenic Clostridia. Toxins (Basel) 2019 Sep 11;11(9).
    doi: 10.3390/toxins11090525pubmed: 31514424google scholar: lookup
  4. Salari Sedigh H, Rajabioun M, Razmyar J, Kazemi Mehrjerdi H. An unusual necrotic myositis by Clostridium perfringens in a German Shepherd dog: A clinical report, bacteriological and molecular identification. Vet Res Forum 2015 Fall;6(4):349-53.
    pubmed: 26973773
  5. Amorim IM, de Oliveira LGS, Boabaid FM, Martins ADS, Gomes LS, Paixão FM, Falcão ICO, Martins DB, Carvalho ROA, Lima AMV, Borsanelli AC. Clostridium septicum-associated myonecrosis in a dog: case report. Vet Res Commun 2025 Mar 28;49(3):155.
    doi: 10.1007/s11259-025-10726-8pubmed: 40153077google scholar: lookup
  6. Balseiro A, Herrero-García G, García Marín JF, Balsera R, Monasterio JM, Cubero D, de Pedro G, Oleaga Á, García-Rodríguez A, Espinoza I, Rabanal B, Aduriz G, Tuñón J, Gortázar C, Royo LJ. New threats in the recovery of large carnivores inhabiting human-modified landscapes: the case of the Cantabrian brown bear (Ursus arctos). Vet Res 2024 Feb 23;55(1):24.
    doi: 10.1186/s13567-024-01279-wpubmed: 38395920google scholar: lookup
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