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Home / Equine Research Bank / Stem Cells Dev / Adipose-derived stem cells in veterinary medicine: character...
Stem cells and development2015; 24(7); 803-813; doi: 10.1089/scd.2014.0407

Adipose-derived stem cells in veterinary medicine: characterization and therapeutic applications.

Abstract: Mesenchymal stem cells, considered one of the most promising cell types for therapeutic applications due to their capacity to secrete regenerative bioactive molecules, are present in all tissues. Stem cells derived from the adipose tissue have been increasingly used for cell therapy in humans and animals, both as freshly isolated, stromal vascular fraction (SVF) cells, or as cultivated adipose-derived stem cells (ASCs). ASCs have been characterized in different animal species for proliferation, differentiation potential, immunophenotype, gene expression, and potential for tissue engineering. Whereas canine and equine ASCs are well studied, feline cells are still poorly known. Many companies around the world offer ASC therapy for dogs, cats, and horses, although in most countries these activities are not yet controlled by regulatory agencies. This is the first study to review the characterization and clinical use of SVF and ASCs in spontaneously occurring diseases in veterinary patients. Although a relatively large number of studies investigating ASC therapy in induced lesions are available in the literature, a surprisingly small number of reports describe ASC therapy for naturally affected dogs, cats, and horses. A total of seven studies were found with dogs, only two studies in cats, and four in horses. Taken as a whole, the results do not allow a conclusion on the effect of this therapy, due to the generally small number of patients included, diversity of cell populations used, and lack of adequate controls. Further controlled studies are clearly needed to establish the real potential of ASC in veterinary medicine.
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Publication Date: 2015-02-05 PubMed ID: 25556829DOI: 10.1089/scd.2014.0407Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article reviews the use and understanding of adipose-derived stem cells (ASCs), a type of mesenchymal stem cell, within veterinary medicine. The study finds that although ASC therapy shows promise, there is still a need for greater controlled research due to a lack of consistency in study procedures and limited information about the therapy’s efficacy in treating naturally occurring diseases in animals.

Adipose-Derived Stem Cells in Veterinary Medicine

  • The researchers explore the role of mesenchymal stem cells, a type of cell that has promise for therapeutic purposes due to its ability to produce bioactive molecules that support regeneration. These stem cells are primarily sourced from adipose tissue (fat tissue).
  • These adipose-derived stem cells (ASCs) have been used in cell therapy for both humans and animals. They can be used directly as freshly isolated cells or after cultivation in favorable conditions.
  • The study outlines the characterization of ASCs across different animal species, examining factors such as their capacity to proliferate, differentiate, their immunophenotype, gene expression, and potential for tissue engineering.

Current State of ASCs in Veterinary Medicine

  • The study notes that while canine and equine ASCs have been well researched, there is limited information on feline cells.
  • Despite various companies worldwide offering ASC therapy for cats, dogs, and horses, most countries still lack regulatory oversight over these practices.

Challenges with ASC Therapy in Veterinary Medicine

  • This research highlights a significant gap in the current understanding of ASC therapy’s effectiveness in treating spontaneously occurring diseases in veterinary patients.
  • Although numerous studies have researched ASC therapy in induced lesions, there’s a scarcity of studies focusing on naturally affected animals. The research only identified seven studies with dogs, two with cats, and four with horses.
  • The results of these studies were deemed inconclusive due to a small number of participants, diversity in the cell populations used, and the absence of relevant controls.
  • The authors of this research conclude that more substantial, controlled studies are needed to accurately establish the potential and limitations of ASC therapy in veterinary medicine.

Cite This Article

APA
Marx C, Silveira MD, Beyer Nardi N. (2015). Adipose-derived stem cells in veterinary medicine: characterization and therapeutic applications. Stem Cells Dev, 24(7), 803-813. https://doi.org/10.1089/scd.2014.0407

Publication

Stem cells and development
ISSN: 1557-8534
NlmUniqueID: 101197107
Country: United States
Language: English
Volume: 24
Issue: 7
Pages: 803-813

Researcher Affiliations

Marx, Camila
  • 1 Laboratory of Stem Cells and Tissue Engineering, Universidade Luterana do Brasil , Canoas, RS, Brazil .
Silveira, Maiele Dornelles
    Beyer Nardi, Nance

      MeSH Terms

      • Adipocytes / cytology
      • Animals
      • Cats
      • Dogs
      • Horses
      • Mesenchymal Stem Cell Transplantation / veterinary
      • Mesenchymal Stem Cells / classification
      • Mesenchymal Stem Cells / cytology

      Citations

      This article has been cited 31 times.
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