Administration of sulpiride or domperidone for advancing the first ovulation in deep anestrous mares.

The research examines the effect of two substances, sulpiride and domperidone, on advancing the first ovulation in deep anestrous mares. The study concluded that sulpiride was effective in accelerating the transition period and first ovulation, while domperidone was only successful in some mares.

Objective of the Study

• The study aimed to compare the efficacy of sulpiride and domperidone in stimulating ovulation in deep anestrous mares (non-pregnant, non-lactating mares) under the same experimental conditions.

Study Design and Population

• Twenty-six non-pregnant, non-lactating standardbred anestrous mares were randomly assigned to three groups. For 25 days, these mares were treated with either sulpiride or domperidone; six mares were left untreated as a control group.

Treatments

• Sulpiride was administered at a dosage of 1mg/kg of body weight im SID to ten mares.
• Domperidone was administered at an equal dosage, 1mg/kg po SID, to another ten mares.
• Six mares were not treated and served as the control group.

Findings

• The onset of the transition period and first ovulation occurred faster in the sulpiride-treated group than in the domperidone-treated or control groups.
• The size of the largest follicle, an indicator of ovulation readiness, significantly increased in the sulpiride group.
• Although treatment didn’t considerably affect plasma LH concentration, time and interaction of treatment-by-day were statistically significant. This implies that treatment timing and continuation had a stronger influence than the type of treatment.

Effects on Intervals and Pregnancy Rates

• The period from the beginning of treatment to first ovulation was shorter in the sulpiride group than in the domperidone and control groups.
• The establishment of pregnancy occurred significantly faster in the sulpiride-treated group compared to the domperidone-treated and control groups.

Conclusion

• The study concluded that sulpiride effectively advances the start of the transition period and the first ovulation in deep anestrous mares, while domperidone is only successful in some mares.