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Administration safety of medical-grade honey (MGH) in septic synovial structures in horses: 3 cases.

Abstract: The objective of this study was to investigate the postoperative use of intrasynovial honey as an antimicrobial after treatment for synovial sepsis in horses. One colt and 2 mares were presented with acute lameness, with or without an associated wound. All 3 cases were initially managed with surgical endoscopic or tenoscopic debridement and lavage for treatment of different synovial structures. Collection of synovial fluid was consistent with synovial sepsis and this was diagnosed in each case. All horses subsequently underwent arthroscopic lavage under general anesthetic and intraarticular or intrathecal medical-grade honey (MGH) was then instilled. All 3 cases recovered well and were free from lameness at all gaits. Although there is extensive research about the antimicrobial properties of honey and growing interest in the biocompatibility of honey in joints with the use of honey hydrogels in human medicine, the research in veterinary medicine is lacking. There are studies describing the antimicrobial properties of honey in healing wounds in horses, but there are no published studies describing the use of honey within a synovial structure. Further research is necessary to assess the biocompatibility of honey in equine articular cartilage. In the cases described in this article, the use of honey demonstrated a safe adjunctive therapy after conventional surgical treatment for septic arthritis. L’objectif de cette étude était d’étudier l’utilisation postopératoire du miel intrasynovial comme antimicrobien après le traitement d’une infection synoviale chez les chevaux. Un poulain et deux juments ont été présentés avec une boiterie aiguë, avec ou sans plaie associée. Les trois cas ont été initialement pris en charge par un débridement chirurgical endoscopique ou ténoscopique et un lavage pour le traitement de différentes structures synoviales. La collecte de liquide synovial était compatible avec une infection synoviale et celle-ci a été diagnostiquée dans chaque cas. Tous les chevaux ont ensuite subi un lavage arthroscopique sous anesthésie générale et du miel de qualité médicale (MGH) intra-articulaire ou intrathécal a ensuite été instillé. Les trois cas se sont bien rétablis et étaient exempts de boiterie à toutes les allures. Bien qu’il existe des recherches approfondies sur les propriétés antimicrobiennes du miel et un intérêt croissant pour la biocompatibilité du miel dans les articulations avec l’utilisation d’hydrogels de miel en médecine humaine, la recherche en médecine vétérinaire fait défaut. Il existe des études décrivant les propriétés antimicrobiennes du miel dans la cicatrisation des plaies chez les chevaux, mais aucune étude publiée ne décrit l’utilisation du miel dans une structure synoviale. Des recherches supplémentaires sont nécessaires pour évaluer la biocompatibilité du miel dans le cartilage articulaire équin. Dans les cas décrits dans cet article, l’utilisation du miel a démontré une thérapie d’appoint sûre après le traitement chirurgical conventionnel de l’arthrite septique.(Traduit par Docteur Serge Messier).
Publication Date: 2023-04-07 PubMed ID: 37020573PubMed Central: PMC10069145
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  • Journal Article

Summary

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This research article investigates the use of medical-grade honey as a post-surgery antimicrobial treatment within the joints of horses. The application of this honey was carried out after traditional surgical procedures to treat synovial sepsis, with promising results.

Study Methodology and Participants

  • The study was carried out on three horses – one colt and two mares presenting with acute lameness, with some horses showing associated wounds.
  • Each horse was initially treated with endoscopic or tenoscopic surgical debridement and lavage for different synovial structures.
  • Synovial fluid collection from the horses was consistent with synovial sepsis, confirming the diagnosis in each case.

Treatment Process

  • Following the initial treatment, all horses underwent arthroscopic lavage under general anesthesia.
  • Post this procedure, intraarticular or intrathecal medical-grade honey (MGH) was administered within the joint.
  • The horses then recovered well from the procedure and were free from lameness at all gaits.

Limited Veterinary Research on Honey as an Antimicrobial Agent Within Joints

  • Despite extensive research on honey’s antimicrobial properties and growing interest in the biocompatibility of honey within joints in human medicine, this is still a relatively unexplored area in veterinary medicine.
  • Studies have been conducted demonstrating the antimicrobial properties of honey in healing wounds in horses, but there are no published studies describing the use of honey within a synovial structure.

Conclusions and Implications for Future Research

  • In the cases described in the research article, the usage of honey demonstrated to be a safe and effective supplemental therapy post conventional surgical treatments for septic arthritis in horses.
  • However, further research is called for to assess the biocompatibility of honey with equine articular cartilage.
  • The potential broadening of medical-grade honey applications in veterinary medicine could provide newer, effective treatment methods for various ailments.

Cite This Article

APA
Terschuur JA, Coomer RPC, McKane SA. (2023). Administration safety of medical-grade honey (MGH) in septic synovial structures in horses: 3 cases. Can J Vet Res, 87(2), 153-156.

Publication

ISSN: 1928-9022
NlmUniqueID: 8607793
Country: Canada
Language: English
Volume: 87
Issue: 2
Pages: 153-156

Researcher Affiliations

Terschuur, Janine A
  • Cotts Equine Hospital - Surgery, Robeston Wathen, Narberth, Pembrokeshire SA67 8EY, United Kingdom.
Coomer, Richard P C
  • Cotts Equine Hospital - Surgery, Robeston Wathen, Narberth, Pembrokeshire SA67 8EY, United Kingdom.
McKane, Shaun A
  • Cotts Equine Hospital - Surgery, Robeston Wathen, Narberth, Pembrokeshire SA67 8EY, United Kingdom.

MeSH Terms

  • Horses
  • Animals
  • Male
  • Female
  • Humans
  • Honey
  • Lameness, Animal
  • Synovial Fluid
  • Anti-Infective Agents
  • Sepsis / veterinary
  • Horse Diseases

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