Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction.
Abstract: To determine the dose of aerosolized albuterol sulfate required to cause bronchodilation in horses with recurrent airway obstruction (RAO) and duration of this effect. Methods: 19 horses with RAO (10 in experiment 1; 9 in experiment 2). Methods: Horses were moved from pasture to stables, and airway obstruction was induced. Pulmonary function was measured in 10 horses before and 5, 10, and 30 minutes after administration of vehicle or 120, 240, 360, or 720 microg of the drug. Nine horses received vehicle or 360 or 720 microg of albuterol, and pulmonary function was measured at baseline and 5 minutes and 1, 2, 3, 4, 5, 6, and 7 hours later. Horses were evaluated for adverse drug effects. Results: 360 microg of albuterol was required to cause significant bronchodilatation; 720 microg did not enhance bronchodilatation or increase duration of action. Depending on which pulmonary function parameter was evaluated, bronchodilatation achieved by use of albuterol lasted between 30 minutes and 1 hour. Because there was a significant vehicle effect, the combined effect of vehicle and drug lasted up to 3 hours. Adverse effects were not observed. Conclusions: Aerosolized albuterol, 360 or 720 microg, is a safe and effective bronchodilator in horses with RAO. Onset of action is rapid (5 minutes), and effects last from 30 minutes to 3 hours. Conclusions: Aerosolized albuterol is useful for treatment of bronchospasm in horses with RAO.
Publication Date: 1999-06-22 PubMed ID: 10376893
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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This research investigates the optimal dose and duration of bronchodilation effect of aerosolized albuterol sulfate on horses with recurrent airway obstruction (RAO), with outcomes suggesting 360 or 720 microg is safe and effective, lasting between 30 minutes and 3 hours.
Objective and Methods
- The study aimed to identify the needed dose of aerosolized albuterol sulfate, a bronchodilator, for horses with recurrent airway obstruction (RAO) and to measure the length of time the drug’s effect lasts.
- The research utilized 19 horses suffering from RAO, divided into two groups (10 in the first experiment and 9 in the second).
- Through a process of inducing airway obstructions in stabled horses, the researchers measured the pulmonary function before and after administrating different dosages of the drug. These measurements were made at various intervals depending on the experiment.
Results
- The results indicated that a dose of 360 micrograms of aerosolized albuterol sulfate was required to bring about significant bronchodilation in the horses.
- The study stated that a further increase to 720 micrograms did not provide any significant enhancement to the bronchodilation or extend the duration of the drug’s effect.
- The duration of bronchodilation was found to largely depend on the specific pulmonary function parameter evaluated. Generally, the bronchodilation effect from albuterol was observed to last between 30 minutes to 1 hour.
- However, when considered alongside the vehicle effect, the pulmonary function improvement was extended to last up to 3 hours.
- Importantly, the study did not observe any adverse effects from the drug administration.
Conclusions
- The research concluded that 360 or 720 micrograms of aerosolized albuterol sulfate can be a safe and effective treatment in inducing bronchodilation in horses suffering from RAO.
- The action of the drug was found to be rapid (beginning in 5 minutes) and could last anywhere from 30 minutes to 3 hours.
- Therefore, the study supports the use of aerosolized albuterol sulfate in treating bronchospasm in horses with RAO.
Cite This Article
APA
Derksen FJ, Olszewski MA, Robinson NE, Berney C, Hakala JE, Matson CJ, Ruth DT.
(1999).
Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction.
Am J Vet Res, 60(6), 689-693.
Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314, USA.
MeSH Terms
- Administration, Inhalation
- Aerosols
- Airway Obstruction / drug therapy
- Airway Obstruction / veterinary
- Albuterol / administration & dosage
- Albuterol / therapeutic use
- Animals
- Bronchodilator Agents / administration & dosage
- Bronchodilator Agents / therapeutic use
- Horse Diseases / drug therapy
- Horses
- Recurrence
- Respiratory Function Tests / veterinary
Citations
This article has been cited 11 times.- Secombe C, Adler A, Hosgood G, Raisis A, Mosing M. Can bronchoconstriction and bronchodilatation in horses be detected using electrical impedance tomography?. J Vet Intern Med 2021 Jul;35(4):2035-2044.
- Couetil L, Cardwell JM, Leguillette R, Mazan M, Richard E, Bienzle D, Bullone M, Gerber V, Ivester K, Lavoie JP, Martin J, Moran G, Niedźwiedź A, Pusterla N, Swiderski C. Equine Asthma: Current Understanding and Future Directions.. Front Vet Sci 2020;7:450.
- Varegg MS, Kløverød KM, Austnes MK, Siwinska N, Slowikowska M, Zak A, Niedzwiedz A. The effect of single pretreatment with salbutamol on recovery of bronchoalveolar lavage fluid in horses with suspected or confirmed severe equine asthma.. J Vet Intern Med 2019 Mar;33(2):976-980.
- Seddighi R, Doherty TJ. Anesthesia of the geriatric equine.. Vet Med (Auckl) 2012;3:53-64.
- Bullone M, Vargas A, Elce Y, Martin JG, Lavoie JP. Fluticasone/salmeterol reduces remodelling and neutrophilic inflammation in severe equine asthma.. Sci Rep 2017 Aug 18;7(1):8843.
- Arroyo MG, Couëtil LL, Nogradi N, Kamarudin MM, Ivester KM. Efficacy of Inhaled Levalbuterol Compared to Albuterol in Horses with Recurrent Airway Obstruction.. J Vet Intern Med 2016 Jul;30(4):1333-7.
- Ivester KM, Couëtil LL, Zimmerman NJ. Investigating the link between particulate exposure and airway inflammation in the horse.. J Vet Intern Med 2014 Nov-Dec;28(6):1653-65.
- Casoni D, Spadavecchia C, Adami C. Cardiovascular changes after administration of aerosolized salbutamol in horses: five cases.. Acta Vet Scand 2014 Aug 14;56(1):49.
- Mazan MR, Lascola K, Bruns SJ, Hoffman AM. Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol.. Can J Vet Res 2014 Jul;78(3):214-20.
- Dillon PF, Root-Bernstein R, Robinson NE, Abraham WM, Berney C. Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo.. PLoS One 2010 Dec 13;5(12):e15130.
- Pearson W, Charch A, Brewer D, Clarke AF. Pilot study investigating the ability of an herbal composite to alleviate clinical signs of respiratory dysfunction in horses with recurrent airway obstruction.. Can J Vet Res 2007 Apr;71(2):145-51.
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