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American journal of veterinary research1999; 60(6); 689-693;

Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction.

Abstract: To determine the dose of aerosolized albuterol sulfate required to cause bronchodilation in horses with recurrent airway obstruction (RAO) and duration of this effect. Methods: 19 horses with RAO (10 in experiment 1; 9 in experiment 2). Methods: Horses were moved from pasture to stables, and airway obstruction was induced. Pulmonary function was measured in 10 horses before and 5, 10, and 30 minutes after administration of vehicle or 120, 240, 360, or 720 microg of the drug. Nine horses received vehicle or 360 or 720 microg of albuterol, and pulmonary function was measured at baseline and 5 minutes and 1, 2, 3, 4, 5, 6, and 7 hours later. Horses were evaluated for adverse drug effects. Results: 360 microg of albuterol was required to cause significant bronchodilatation; 720 microg did not enhance bronchodilatation or increase duration of action. Depending on which pulmonary function parameter was evaluated, bronchodilatation achieved by use of albuterol lasted between 30 minutes and 1 hour. Because there was a significant vehicle effect, the combined effect of vehicle and drug lasted up to 3 hours. Adverse effects were not observed. Conclusions: Aerosolized albuterol, 360 or 720 microg, is a safe and effective bronchodilator in horses with RAO. Onset of action is rapid (5 minutes), and effects last from 30 minutes to 3 hours. Conclusions: Aerosolized albuterol is useful for treatment of bronchospasm in horses with RAO.
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Publication Date: 1999-06-22 PubMed ID: 10376893
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research investigates the optimal dose and duration of bronchodilation effect of aerosolized albuterol sulfate on horses with recurrent airway obstruction (RAO), with outcomes suggesting 360 or 720 microg is safe and effective, lasting between 30 minutes and 3 hours.

Objective and Methods

  • The study aimed to identify the needed dose of aerosolized albuterol sulfate, a bronchodilator, for horses with recurrent airway obstruction (RAO) and to measure the length of time the drug’s effect lasts.
  • The research utilized 19 horses suffering from RAO, divided into two groups (10 in the first experiment and 9 in the second).
  • Through a process of inducing airway obstructions in stabled horses, the researchers measured the pulmonary function before and after administrating different dosages of the drug. These measurements were made at various intervals depending on the experiment.

Results

  • The results indicated that a dose of 360 micrograms of aerosolized albuterol sulfate was required to bring about significant bronchodilation in the horses.
  • The study stated that a further increase to 720 micrograms did not provide any significant enhancement to the bronchodilation or extend the duration of the drug’s effect.
  • The duration of bronchodilation was found to largely depend on the specific pulmonary function parameter evaluated. Generally, the bronchodilation effect from albuterol was observed to last between 30 minutes to 1 hour.
  • However, when considered alongside the vehicle effect, the pulmonary function improvement was extended to last up to 3 hours.
  • Importantly, the study did not observe any adverse effects from the drug administration.

Conclusions

  • The research concluded that 360 or 720 micrograms of aerosolized albuterol sulfate can be a safe and effective treatment in inducing bronchodilation in horses suffering from RAO.
  • The action of the drug was found to be rapid (beginning in 5 minutes) and could last anywhere from 30 minutes to 3 hours.
  • Therefore, the study supports the use of aerosolized albuterol sulfate in treating bronchospasm in horses with RAO.

Cite This Article

APA
Derksen FJ, Olszewski MA, Robinson NE, Berney C, Hakala JE, Matson CJ, Ruth DT. (1999). Aerosolized albuterol sulfate used as a bronchodilator in horses with recurrent airway obstruction. Am J Vet Res, 60(6), 689-693.

Publication

American journal of veterinary research
ISSN: 0002-9645
NlmUniqueID: 0375011
Country: United States
Language: English
Volume: 60
Issue: 6
Pages: 689-693

Researcher Affiliations

Derksen, F J
  • Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314, USA.
Olszewski, M A
    Robinson, N E
      Berney, C
        Hakala, J E
          Matson, C J
            Ruth, D T

              MeSH Terms

              • Administration, Inhalation
              • Aerosols
              • Airway Obstruction / drug therapy
              • Airway Obstruction / veterinary
              • Albuterol / administration & dosage
              • Albuterol / therapeutic use
              • Animals
              • Bronchodilator Agents / administration & dosage
              • Bronchodilator Agents / therapeutic use
              • Horse Diseases / drug therapy
              • Horses
              • Recurrence
              • Respiratory Function Tests / veterinary

              Citations

              This article has been cited 14 times.
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              8. Casoni D, Spadavecchia C, Adami C. Cardiovascular changes after administration of aerosolized salbutamol in horses: five cases. Acta Vet Scand 2014 Aug 14;56(1):49.
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              9. Mazan MR, Lascola K, Bruns SJ, Hoffman AM. Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol. Can J Vet Res 2014 Jul;78(3):214-20.
                pubmed: 24982553
              10. Dillon PF, Root-Bernstein R, Robinson NE, Abraham WM, Berney C. Receptor-mediated enhancement of beta adrenergic drug activity by ascorbate in vitro and in vivo. PLoS One 2010 Dec 13;5(12):e15130.
                doi: 10.1371/journal.pone.0015130pubmed: 21179213google scholar: lookup
              11. Pearson W, Charch A, Brewer D, Clarke AF. Pilot study investigating the ability of an herbal composite to alleviate clinical signs of respiratory dysfunction in horses with recurrent airway obstruction. Can J Vet Res 2007 Apr;71(2):145-51.
                pubmed: 17479778
              12. Talavera-López J, Tudela-González A, Muñoz-Prieto A. Use of a Capsaicin Cough Challenge Test to Compare Four Different Techniques for Nebulization Delivery in Cats. Vet Sci 2024 Jul 17;11(7).
                doi: 10.3390/vetsci11070320pubmed: 39058004google scholar: lookup
              13. Mozo Vives B, Mainguy-Seers S, Lavoie JP. Comparative study of the bronchodilator efficacy and adverse effects of salbutamol and hyoscine butylbromide in horses with severe asthma. J Vet Intern Med 2024 May-Jun;38(3):1835-1841.
                doi: 10.1111/jvim.17057pubmed: 38609079google scholar: lookup
              14. Robins TJ, Bedenice D, Mazan M. A Longitudinal Analysis of Equine Asthma Presentation and Response to Treatment Using Lung Function Testing and BAL Cytology Analysis in Combination with Owner Perception. Animals (Basel) 2023 Nov 1;13(21).
                doi: 10.3390/ani13213387pubmed: 37958142google scholar: lookup
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