Age over 25 years, but not plasma adrenocorticotropic hormone con-cen-tration above the seasonally adjusted reference range is predictive for radio-graphically assessed changes of chronic laminitis in elderly horses.
Abstract: Endocrinopathic laminitis occurs as a consequence of hormonal derangements like pituitary pars intermedia dysfunction (PPID). The objective of the present study was to assess the occurrence of radiographic changes associated with chronic laminitis in elderly, clinically sound horses. Fifty-one horses were included in the study. Horses were assigned to different age groups, in groups according to their BCS and CNS as well as to groups with different ACTH concentrations in order to assess their risk of chronic laminitis (reported as odds ratios (OR) and confidence intervals (CI)). Horses assigned to an older age group (26-32 years) were significantly more likely to have radiographically assessed changes of chronic laminitis than horses in a younger age group (15-25 years) (OR 3.33; CI 1.05-10.59). The other variables (body condition score, cresty neck score, ACTH concentration) were not associated with an increased risk of having laminitic changes in these horses. Endokrinologische Veränderungen in Folge eines equinen Cushing Syndroms (ECS, PPID) sind die häufigste Ursache für Hufrehe bei älteren Pferden. Ziel dieser Studie war es, das Vorkommen röntgenologisch diagnostizierter, chronischer Hufrehe bei Pferden einer älteren Population zu ermitteln. Insgesamt wurden 51 Pferde untersucht. Innerhalb dieses Projektes sollte herausgefunden werden, ob Pferde einer höheren Altersgruppe, einer Gruppe mit Anzeichen von Adipositas (anhand des «body condition score», «cresty neck score») oder einer ACTH Konzentration oberhalb des saisonalen Referenzwertes ein höheres Risiko für chronische Hufrehe haben (Resultate werden als Odds-Ratio (OR) und Konfidenzintervall (KI) angegeben). Nach Einteilung der Pferde in zwei Gruppen aufgrund des Alters stellte sich ein signifikanter Zusammenhang heraus, wobei die Tiere der älteren Gruppe (26–32 Jahre) ein erhöhtes Risiko für radiologische Anzeichen chronischer Hufrehe hatten im Vergleich zur jüngeren Gruppe (15–25 Jahre) (OR 3.33; KI 1.05–10.59). Die anderen Parameter (Ernährungszustand, ACTH-Konzentration) hatten keinen Einfluss auf das Risiko für chronische Hufrehe in dieser Population. La fourbure endocrinopathique survient à la suite de troubles hormonaux tels que le dysfonctionnement de la pars intermedia de l’hypophyse (DPIH). L’objectif de la présente étude était d’évaluer les changements radiographiques associés à la fourbure subclinique chez les chevaux âgés cliniquement sains. Cinquante et un chevaux ont été inclus dans l’étude. Les chevaux ont été assignés à différents groupes d’âge, en groupes en fonction de leur Body Condition Score (BCS) et de leur Cresty Neck Score (CNS) ainsi que des groupes avec différentes concentrations d’ACTH afin d’évaluer leur risque de fourbure chronique (rapportés sous forme de rapports de cotes (Odds-Ratio, OR) et d’intervalles de confiance (IC)). Les chevaux faisant partie d’un groupe d’âge plus avancé (26 à 32 ans) étaient significativement plus susceptibles de présenter des signes radiographiques de fourbure chronique que les chevaux d’un groupe d’âge plus jeune (15 à 25 ans) (OR 3,33; IC 1,05–10,59). Les autres variables (BCS, CNS, concentration d’ACTH) n’étaient pas associées à un risque accru de modifications de type fourbure chez ces chevaux. La laminite endocrinopatica insorge in quanto conseguenza di squilibri ormonali come la disfunzione della pars intermedia ipofisaria (PPID). L’obiettivo dello studio qui di seguito era di valutare l’incidenza dei cambiamenti radiografici associati alla laminite cronica nei cavalli anziani, clinicamente sani. Per lo studio sono stati esaminati 51 cavalli. I cavalli sono stati assegnati a differenti gruppi di età, al loro body condition score (BCS), al loro cresty neck score (CNS) e a gruppi con concentrazioni di ACTH differenti, in modo da valutare il rischio di sviluppo di una laminite cronica (i risultati sono riportati come odds ratio (OR) e intervallo di confidenza (CI)). I cavalli appartenenti a un gruppo di età più anziano (26–32 anni) sviluppavano una maggiore probabilità di mostrare dei cambiamenti radiografici associati alla laminite cronica che il gruppo di cavalli più giovani (12–25 anni) (OR 3,33; CI 1.05–10,59). Le altre variabili (body condition score, cresty neck score e concentrazione di ACTH) non sono state correlata a un aumento del rischio di laminite cronica in questa popolazione.
Publication Date: 2020-12-03 PubMed ID: 33263545DOI: 10.17236/sat00283Google Scholar: Lookup
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- Journal Article
- Age Factors
- Body Condition Score
- Chronic Diseases
- Clinical Study
- Diagnosis
- Disease Diagnosis
- Disease Etiology
- Endocrine System
- Epidemiology
- Equine Health
- Geriatric Horses
- Hoof Health
- Hormones
- Horses
- Lameness
- Observational Study
- Pituitary Pars Intermedia Dysfunction
- Radiology
- Senior Horses
- Veterinary Medicine
- Veterinary Research
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research seeks to determine the link between age, specific hormone levels, and the occurrence of chronic laminitis in horses. It was found that horses over 25 years were more likely to have laminitis, regardless of their adrenocorticotropic hormone concentrations.
Research Parameters and Methodology
- The study focused on evaluating radiographic changes associated with chronic laminitis in healthy elderly horses. The chronic inflammation of the laminae tissues in the hoof, known as laminitis, is a common issue in aging horses.
- The sample size was 51 horses. These horses were divided into groups based on their age, Body Condition Score (BCS), Cresty Neck Score (CNS), and Adrenocorticotropic Hormone (ACTH) concentrations.
- The objective was to define the risk profile of chronic laminitis in these categories, expressed in odds ratios (OR) and confidence intervals (CI).
Findings
- It was found that horses in the older age group (26-32 years) had a significantly higher risk of exhibiting radiographic changes related to chronic laminitis than horses in the younger age group (15-25 years).
- The risk factor odds ratio for the older age group was found to be 3.33 within a confidence interval of 1.05-10.59. This suggests that an older horse is over three times more likely to have developed chronic laminitis than younger horses.
- Interestingly, the study discovered that other parameters including Body Condition Score (BCS), Cresty Neck Score (CNS), and their ACTH concentrations were not linked with an increased risk of chronic laminitis.
Implications
- The study provides vital insights on chronic laminitis in horses, notably that age is a significant risk factor.
- While high ACTH concentration is usually associated with hormonal imbalances like Pituitary Pars Intermedia Dysfunction (PPID) and is a common cause of laminitis, this research found no such correlation for the population studied.
- Although the paper does not directly suggest practice changes, the results could lead to increased attention to hoof care and overall health assessment for older horses to identify and manage laminitis early.
Cite This Article
APA
Christen G, Precht C, van der Kolk J, Fouché N, Gerber V.
(2020).
Age over 25 years, but not plasma adrenocorticotropic hormone con-cen-tration above the seasonally adjusted reference range is predictive for radio-graphically assessed changes of chronic laminitis in elderly horses.
Schweiz Arch Tierheilkd, 162(12), 781-785.
https://doi.org/10.17236/sat00283 Publication
Researcher Affiliations
- Swiss Institute of Equine Medicine (ISME), Vetsuisse Faculty, University of Bern, and Agroscope, Switzerland.
- Department of Clinical Veterinary Medicine, Clinical Radiology, Vetsuisse Faculty, University of Bern.
- Swiss Institute of Equine Medicine (ISME), Vetsuisse Faculty, University of Bern, and Agroscope, Switzerland.
- Swiss Institute of Equine Medicine (ISME), Vetsuisse Faculty, University of Bern, and Agroscope, Switzerland.
- Swiss Institute of Equine Medicine (ISME), Vetsuisse Faculty, University of Bern, and Agroscope, Switzerland.
MeSH Terms
- Adrenocorticotropic Hormone / blood
- Age Factors
- Animals
- Chronic Disease / veterinary
- Foot Diseases / diagnostic imaging
- Foot Diseases / physiopathology
- Foot Diseases / veterinary
- Hoof and Claw / diagnostic imaging
- Horse Diseases / blood
- Horse Diseases / diagnostic imaging
- Horse Diseases / physiopathology
- Horses
- Reference Values
Citations
This article has been cited 1 times.- Wang L, Unger L, Sharif H, Eriksson S, Gerber V, Rönnberg H. Molecular characterization of equine thymidine kinase 1 and preliminary evaluation of its suitability as a serum biomarker for equine lymphoma. BMC Mol Cell Biol 2021 Dec 14;22(1):59.
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