Airway response of horses with COPD to dry powder inhalation of ipratropium bromide.
Abstract: To determine the effects of the dry powder inhalation (DPI) of ipratropium bromide (ipratropium) on the airways of health horses and the dose-response curve in horses suffering from chronic obstructive pulmonary disease (COPD) by means of pulmonary function tests, five healthy horses were first studied. Ipratropium (2400 micrograms ipratropium horse-1) was contained in gelatine capsules and administered using a dry powder device connected to an adapted face mask. Pulmonary function tests were recorded before inhalation and 15 and 60 min after inhalation. No modification of pulmonary function was observed. The airway response to ipratropium DPI was then determined in six horses suffering from COPD. To induce airway obstruction, the horses were bedded on straw and fed hay. When the maximal change in pleural pressure during tidal breathing exceeded 1.96 kPa, pulmonary function tests were recorded before DPI, and 15 and 60 min post-inhalation. Placebo (six capsules horse-1) or ipratropium (600, 1200 and 2400 micrograms horse-1) was administered in a randomized order to each horse using the dry powder device and the adapted face mask. Neither ipratropium nor placebo DPI affected respiratory frequency (f) or tidal volume (VT). Inhalation of 600 micrograms ipratropium horse-1 resulted in a delayed decrease of total pulmonary resistance (RL) whereas dynamic compliance (Cdyn) was improved (although not significantly) at both times of measurement when compared with values following placebo inhalation. Simultaneous decreased RL and increased Cdyn, was observed within 15 min after DPI of 1200 micrograms ipratropium horse-1 and persisted for the 1 h duration of the experiment. Doubling the dose also improved pulmonary function but not significantly more than following inhalation of 1200 micrograms ipratropium. No systemic side effects were observed in either group of horses.
Publication Date: 1997-10-06 PubMed ID: 9308401DOI: 10.1016/s1090-0233(97)80052-4Google Scholar: Lookup
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- Journal Article
- Bronchodilation
- Chronic Obstructive Pulmonary Disease
- Clinical Examination
- Clinical Pathology
- Clinical Study
- Diagnosis
- Disease Diagnosis
- Disease Treatment
- Drug
- Equine Diseases
- Equine Health
- Horses
- Inhalation
- Pharmacodynamics
- Pharmacology
- Placebo
- Pulmonary Health
- Respiratory Disease
- Respiratory Health
- Veterinary Medicine
- Veterinary Research
Summary
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This study explores the impact of dry powder inhalation (DPI) of ipratropium bromide on healthy horses and those suffering from Chronic Obstructive Pulmonary Disease (COPD). The experiments conducted revealed that inhaling ipratropium bromide doesn’t significantly change respiratory frequency or tidal volume, but can decrease overall pulmonary resistance and potentially enhance dynamic compliance.
Research Process
- The research began with a focus on understanding the effect of dry powder inhalation (DPI) of ipratropium bromide on healthy horses. In this experiment, 5 healthy horses were given ipratropium bromide through DPI and their pulmonary function was tested before intake, then after 15 minutes and after 60 minutes.
- To figure out how horses struggling with COPD react to inhaling ipratropium bromide in various quantities, a pool of six horses with COPD was observed. Airway obstruction was induced by allowing them to feed on hay and be bedded on straw, simulating a situation that could trigger COPD. The horse’s pulmonary function was recorded before the start of the experiment and then after 15 minutes and 60 minutes post-DPI.
- Placebo and different doses of ipratropium bromide (600, 1200 and 2400 micrograms) were given to horses in a randomized order using the dry powder device and an adapted face mask. Pulmonary functions were recorded at intervals to track responses to these variable ipratropium bromide doses.
Research Findings
- The DPI of ipratropium bromide, regardless of being a placebo or at doses of 600, 1200, and 2400 micrograms, did not cause alterations to the respiratory frequency or tidal volume in horses.
- In horses with COPD, DPI of 600 micrograms of ipratropium bromide caused a delayed reduction in total pulmonary resistance (RL) while potentially improving the dynamic compliance (Cdyn), although not significantly.
- Administering 1200 micrograms of ipratropium bromide led to an immediate reduction in RL and an increase in Cdyn within 15 minutes post-DPI, an effect that was sustained throughout the hour-long duration of the experiment.
- Doubling the dose of ipratropium bromide to 2400 micrograms led to an improved pulmonary function, although not significantly more than after the inhalation of 1200 micrograms.
- There were no recorded systemic side effects from this drug on either group of horses following its administration.
Cite This Article
APA
Duvivier DH, Votion D, Vandenput S, Art T, Lekeux P.
(1997).
Airway response of horses with COPD to dry powder inhalation of ipratropium bromide.
Vet J, 154(2), 149-153.
https://doi.org/10.1016/s1090-0233(97)80052-4 Publication
Researcher Affiliations
- Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liège, Sart Tilman, Belgium.
MeSH Terms
- Administration, Inhalation
- Animals
- Bronchodilator Agents / administration & dosage
- Bronchodilator Agents / pharmacology
- Dose-Response Relationship, Drug
- Horse Diseases / drug therapy
- Horses
- Ipratropium / administration & dosage
- Ipratropium / pharmacology
- Lung Diseases, Obstructive / drug therapy
- Lung Diseases, Obstructive / veterinary
- Respiratory Function Tests / veterinary
Citations
This article has been cited 1 times.- Törneke K, Ingvast-Larsson C, Boström A, Appelgren LE. Muscarinic receptors in equine airways. Vet Res Commun 2002 Dec;26(8):637-50.
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