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Home / Equine Research Bank / Vet Surg / Allogeneic chondrogenic-induced mesenchymal stem cells for t...
Veterinary surgery : VS2023; doi: 10.1111/vsu.14030

Allogeneic chondrogenic-induced mesenchymal stem cells for the treatment of tarsometatarsal lameness in horses.

Abstract: To assess the efficacy of commercial intra-articular blood-derived allogeneic-induced mesenchymal stem cells (CIMSCs) to treat tarsometatarsal lameness in horses. Methods: This was a retrospective cohort study. Methods: Records from 167 adult light breed horses with bilateral tarsometatarsal lameness. Methods: Horses with tarsometatarsal lameness were retrospectively selected from medical records. Diagnosis followed subjective graded lameness assessment before and after intra-articular analgesia, with graded radiographic tarsal examination. Horses were excluded if they were diagnosed or treated for any other concurrent lameness conditions during the study. Time to last follow-up and time of recurrence of lameness was recorded at veterinary re-assessment. Results: A total of 67 horses were recruited to the CIMSC-treated group and 100 to the corticosteroid (CS)-treated group. Median age was 9 years, with no difference in signalment, use or radiographic grade between groups. First re-examination was 38 days (95% CI: 38-49), with no difference between groups, CIMSC 42 (35-45), control 34 (25-42). Median follow-up was 438 days for CIMSC, 546 for controls. Symptoms of lameness recurred in 86/100 controls compared to 17/67 (25%) CIMSC. Median time to lameness recurring in CIMSC was 336 days (95% CI: 239-400), control 90 days (95% CI: 80-108), p < .0001. Cox proportional hazard ratio for treatment was 8.35, 95% CI: 4.67 to 14.92, p < .0001. Conclusions: Lameness was abolished in all treated horses. It recurred significantly less often, and later, in CIMSC-treated horses. Conclusions: Intra-articular CIMSC treatment results in prolonged soundness in horses with tarsometatarsal lameness.
© 2023 The Authors. Veterinary Surgery published by Wiley Periodicals LLC on behalf of American College of Veterinary Surgeons.
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Publication Date: 2023-09-08 PubMed ID: 37681480DOI: 10.1111/vsu.14030Google Scholar: Lookup
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Summary

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The research article explores the use of commercial intra-articular blood-derived allogeneic-induced mesenchymal stem cells (CIMSCs) in treating lameness in horses’ tarsometatarsal joints and concludes that CIMSC treatment results in prolonged soundness compared to traditional corticosteroid treatment.

Objective of the Study

  • The main goal of this study was to evaluate the effectiveness of a commercial intra-articular blood-derived allogeneic-induced mesenchymal stem cells (CIMSCs) treatment in managing tarsometatarsal lameness in horses.

Methodology

  • The researchers conducted a retrospective review of medical records from 167 adult light breed horses suffering from bilateral tarsometatarsal lameness.
  • The lameness was diagnosed through subjective graded lameness assessment before and after intra-articular analgesia, accompanied by graded radiographic examination of the tarsal area.
  • Horses that were diagnosed or treated for any other concurrent lameness conditions during the study were excluded.
  • The researchers then tracked the time to the last follow-up and the recurrence time of lameness as documented at veterinary reassessments.

Results

  • 67 horses were assigned to the CIMSC-treated group, while 100 horses were designated for corticosteroid (CS)-treatment.
  • Both groups had an average age of 9 years and showed no significant difference in terms of use, signalment, or radiographic grade.
  • The first re-examination was conducted after a median of 38 days, without any substantial difference between the two groups. The median follow-up time was 438 days for the CIMSC group, and 546 days for the control (CS-treatment) group.
  • Lameness symptoms recurred in 86 out of 100 horses in the control group, compared to only 17 out of 67 horses (25%) in the CIMSC-treated group.
  • Median time to lameness recurrence was significantly longer in CIMSC-treated horses at 336 days, compared to 90 days in the control group.
  • The results reflected an 8.35 Cox proportional hazard ratio for treatment, signifying a remarkable decrease in lameness incidence in the CIMSC group.

Conclusions

  • The study concludes that lameness in all treated horses was eradicated.
  • However, recurrence was significantly less frequent and more delayed in the CIMSC-treated group.
  • Therefore, the study suggests that intra-articular CIMSC treatment presents a more effective and prolonged solution to manage tarsometatarsal lameness in horses, compared to corticosteroid treatment.

Cite This Article

APA
Coomer RPC, Terschuur JA, Pressanto MC, Walker I. (2023). Allogeneic chondrogenic-induced mesenchymal stem cells for the treatment of tarsometatarsal lameness in horses. Vet Surg. https://doi.org/10.1111/vsu.14030

Publication

Veterinary surgery : VS
ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English

Researcher Affiliations

Coomer, Richard P C
  • Cotts Equine Hospital, Narberth, UK.
Terschuur, Janine A
  • Cotts Equine Hospital, Narberth, UK.
Pressanto, M Chiara
  • Cotts Equine Hospital, Narberth, UK.
Walker, Ian
  • School of Psychology, Swansea University, Swansea, UK.

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