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Home / Equine Research Bank / Am J Respir Cell Mol Biol / Allometric relationships of cell numbers and size in the mam...
American journal of respiratory cell and molecular biology1992; 6(2); 235-243; doi: 10.1165/ajrcmb/6.2.235

Allometric relationships of cell numbers and size in the mammalian lung.

Abstract: Allometric studies have shown that lung volume, alveolar surface area, and diffusing capacity increase proportionally with body weight across a broad range of mammalian species. Changes in the number of cells and in average cell size and surface areas with increasing body weight have not been defined. We speculated that cell size is determined more by cell function than by species and body weight. To test this hypothesis, nine species ranging in size from shrew (2 to 3 g) to horse (510 kg) were studied. Random sites from the distal alveolar region of each species were analyzed using morphometric techniques. Six to 10 nuclei from each of the major classes of parenchymal lung cells were three-dimensionally reconstructed to determine their average diameter, volume, and surface area. To calculate the cell density, nuclear profiles were counted using electron microscopy. The number of cells per lung increased with body mass and lung volume with a slope of 1.01 (r2 = 0.99). The lung is unique among organs in the diversity and function of individual cell types, such as mechanical, sensory, secretory, transporting, and circulating cells. Excluding the circulatory cells, the lung has greater than 60 different cell types, making it an ideal organ for examining the varieties in cell characteristics across different species. Up to 6-fold differences in size were found between different lung cell types within a single species; however, for cells having secretory functions, such as type II cells, there was no detectable change in cell size with increasing lung surface area or body mass.(ABSTRACT TRUNCATED AT 250 WORDS)
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Publication Date: 1992-02-01 PubMed ID: 1540387DOI: 10.1165/ajrcmb/6.2.235Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • U.S. Gov't
  • Non-P.H.S.
  • Research Support
  • U.S. Gov't
  • P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigates the relationship between cell size and function in the lungs of mammals across various species from tiny shrews to large horses. It discovered that the number of cells increased proportionally to body mass and lung volume, while for some types of cells, such as the type II cells which have secreting functions, cell size remained constant despite increases in body mass or lung surface area.

Investigating Allometric Relationships of Lung Cell Numbers and Size

The research aimed to understand:

  • How lung cell numbers and sizes change with different body weights across a diverse set of mammals.
  • The possible relationship between cell size and function rather than species and body weight.

Methodology of the Research

To conduct the study, morphometric techniques were used to analyze random sites from the distal alveolar region of nine different mammalian species, ranging from shrews (whom weigh between 2 and 3 grams) to horses (whom weigh up to 510 kilograms). The study:

  • Three-dimensionally reconstructed six to 10 nuclei from each of the major classes of parenchymal lung cells to determine their average diameter, volume, and surface area.
  • Counted nuclear profiles using electron microscopy to calculate cell density.

Results of the Study

The research revealed:

  • The cell number per lung increased with body mass and lung volume to a slope of 1.01 with a coefficient of determination (r2) equal to 0.99, indicating a proportional relationship.
  • There was a wide variety of cell sizes due to the diverse functions found in the lung.
  • Despite the inherent diversity, in certain cells (like type II cells which have secretory functions), there was no detectable size change when there was an increase in the area of the lung surface or the body mass.

Through this research, new insights into the relationships between cell size, function, and body mass can be gleaned that challenge previous notions about cell size being more influenced by species or body weight. More in-depth understanding of these relationships can contribute to medical fields such as pulmonary medicine and developmental biology.

Cite This Article

APA
Stone KC, Mercer RR, Gehr P, Stockstill B, Crapo JD. (1992). Allometric relationships of cell numbers and size in the mammalian lung. Am J Respir Cell Mol Biol, 6(2), 235-243. https://doi.org/10.1165/ajrcmb/6.2.235

Publication

American journal of respiratory cell and molecular biology
ISSN: 1044-1549
NlmUniqueID: 8917225
Country: United States
Language: English
Volume: 6
Issue: 2
Pages: 235-243

Researcher Affiliations

Stone, K C
  • Departments of Medicine, Duke University Medical Center, Durham, North Carolina.
Mercer, R R
    Gehr, P
      Stockstill, B
        Crapo, J D

          MeSH Terms

          • Animals
          • Cell Count
          • Cricetinae
          • Female
          • Guinea Pigs
          • Horses
          • Humans
          • Lung / cytology
          • Male
          • Mammals
          • Mice
          • Rats
          • Shrews
          • Species Specificity

          Grant Funding

          • P01 HL31992 / NHLBI NIH HHS
          • R01 HL42609 / NHLBI NIH HHS

          Citations

          This article has been cited 189 times.
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