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Clinical implant dentistry and related research2008; 11(2); 90-100; doi: 10.1111/j.1708-8208.2008.00104.x

Alveolar ridge regeneration with equine spongy bone: a clinical, histological, and immunohistochemical case series.

Abstract: In the case of localized ridge atrophy, a ridge augmentation procedure, with the use of bone substitutes and barrier membranes, may then be necessary. Objective: The aim of the present study was a clinical, histological, and immunohistochemical evaluation of an equine spongy bone in alveolar ridge augmentation procedures. Methods: Five patients showing horizontal mandibular ridge defects participated in this study. A ridge augmentation was performed through an onlay apposition of equine bone covered by a titanium-reinforced membrane. After 6 months of healing, five bone cores from nonaugmented sites (control) and five from augmented sites (test) were retrieved. Results: In test sites, no postoperative complications occurred. Horizontal bone width increased from 24 to 37 mm. In control sites, the newly formed bone represented 33%, and in test sites, 35% of the total area. The mean value of the microvessel density was 25.6 +/- 3.425 per mm(2) in controls, while 33.3 +/- 2.5 vessels per mm(2) in the test sites were found (p < .05). Both groups showed a high intensity (++) of vascular endothelial growth factor expression in the newly formed bone, while a low intensity (+) was found in the mature bone. Conclusions: Equine bone appeared to be biocompatible and to be associated with new vessel ingrowth. Within the limits of the small sample size, the present study indicated that equine bone could be used in mandibular ridge augmentations.
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Publication Date: 2008-09-09 PubMed ID: 18783426DOI: 10.1111/j.1708-8208.2008.00104.xGoogle Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper is about evaluating the use of equine spongy bone for alveolar ridge augmentation, a procedure that may be necessary in cases of localized ridge atrophy. The study concludes that equine bone is biocompatible and can encourage new blood vessel growth, suggesting its potential use in mandibular ridge augmentations.

Objective and Methods of the Study

  • The aim of the study was a clinical, histological, and immunohistochemical evaluation of an equine spongy bone when used in alveolar ridge augmentation procedures, focused on the potential of the equine bone in regenerating alveolar ridge.
  • Five patients suffering from horizontal mandibular ridge defects were incorporated in the study.
  • The study applied a ridge augmentation procedure, where an onlay apposition of equine bone covered by a titanium-reinforced membrane was performed on the patients.
  • The researchers took five bone cores from nonaugmented sites (used as control) and five from the augmented sites (test) after a healing period of six months.

Results of the Study

  • No postoperative complications were observed in the test sites where augmentation was conducted.
  • There was an increase in horizontal bone width from 24 to 37 mm, signifying growth. In the control sites, newly formed bone represented 33% of the total area, while in test sites, it was slightly higher at 35%.
  • The mean value of microvessel density, which refers to the density of blood vessels in the tissue, was found to be higher in the test sites, about 33.3 vessels per mm, compared to 25.6 in control sites.
  • Both groups showed a high intensity of vascular endothelial growth factor expression in the newly formed bone, indicating that formation of blood vessels was stimulated, while mature bone had a low intensity of such expression.

Conclusions from the Research

  • The study concludes that equine bone appears to be biocompatible, indicates no postoperative complications, and seems to promote new vessel growth.
  • The authors consider these findings to suggest that equine bone could potentially be used in mandibular ridge augmentations, particularly to regenerate alveolar ridge, especially considering the lack of complications and the promotion of new vessel growth. However, they caution that the conclusions are drawn on the basis of a small sample size.

Cite This Article

APA
Di Stefano DA, Artese L, Iezzi G, Piattelli A, Pagnutti S, Piccirilli M, Perrotti V. (2008). Alveolar ridge regeneration with equine spongy bone: a clinical, histological, and immunohistochemical case series. Clin Implant Dent Relat Res, 11(2), 90-100. https://doi.org/10.1111/j.1708-8208.2008.00104.x

Publication

Clinical implant dentistry and related research
ISSN: 1708-8208
NlmUniqueID: 100888977
Country: United States
Language: English
Volume: 11
Issue: 2
Pages: 90-100

Researcher Affiliations

Di Stefano, Danilo Alessio
  • Dental School, University of Chieti-Pescara, Italy.
Artese, Luciano
    Iezzi, Giovanna
      Piattelli, Adriano
        Pagnutti, Stefano
          Piccirilli, Marcello
            Perrotti, Vittoria

              MeSH Terms

              • Adult
              • Alkaline Phosphatase / analysis
              • Alveolar Process / blood supply
              • Alveolar Process / pathology
              • Alveolar Ridge Augmentation / methods
              • Animals
              • Biocompatible Materials / therapeutic use
              • Bone Regeneration / physiology
              • Bone Transplantation / methods
              • Bone Transplantation / pathology
              • Cephalometry
              • Endothelium, Vascular / pathology
              • Female
              • Guided Tissue Regeneration / instrumentation
              • Guided Tissue Regeneration / methods
              • Haversian System / pathology
              • Horses
              • Humans
              • Immunohistochemistry
              • Male
              • Mandible / blood supply
              • Mandible / pathology
              • Mandible / surgery
              • Membranes, Artificial
              • Microvessels / pathology
              • Middle Aged
              • Osteocytes / pathology
              • Osteogenesis / physiology
              • Polytetrafluoroethylene
              • Tissue Preservation / methods
              • Titanium
              • Transplantation, Heterologous
              • Vascular Endothelial Growth Factor A / analysis

              Citations

              This article has been cited 19 times.
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