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Home / Equine Research Bank / Biochem J / Amino acid sequences around the cystine residues in horse gr...
The Biochemical journal1968; 109(1); 19-24; doi: 10.1042/bj1090019

Amino acid sequences around the cystine residues in horse growth hormone.

Abstract: The cystine-containing peptides of horse growth hormone were isolated and their amino acid sequences determined. Four unique half-cystine residues occur in two peptides, one containing 11 and the other, at the C-terminus of the protein, 15 amino acids. These sequences are compared with published data on growth hormones from other species.
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Publication Date: 1968-08-01 PubMed ID: 4876100PubMed Central: PMC1186747DOI: 10.1042/bj1090019Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research study deals with the identification of the specific amino acid sequences that surround the cystine residues in horse growth hormone. The researchers isolated the cystine-containing peptides of horse growth hormone and ascertained their amino acid sequences, finding two different peptides with unique sequences.

Isolation and Identification of Amino Acid Sequences

  • The researchers first isolated the cystine-containing peptides of horse growth hormone. Cystine is a sulfur-containing amino acid, which is known to play a critical role in protein structure.
  • After isolating these peptides, the researchers determined their amino acid sequences. Amino acid sequencing is a chemical method used to determine the sequence of amino acids in a protein, peptide, or a single amino acid.
  • They discovered that four unique half-cystine residues occur in two peptides, one containing 11 and the other, at the C-terminus (the end part of an amino acid chain) of the protein, containing 15 amino acids. This suggests that these sequences are particularly important in the structure and function of horse growth hormone.

Comparison with Other Species’ Growth Hormones

  • The identified amino acid sequences were then compared with already published data on growth hormones from other species.
  • This comparative step is key in making inter-species comparisons, understanding evolutionary relationships, and discerning the general principles of growth hormone structure and function across different species.
  • The results of this comparison, while not provided in the abstract, would have shed light on commonalities and differences across species, and possibly hint at any relation between specific sequence patterns around cystine residues and hormone function.

Implications and Significance

  • This research gives insight into the specific sequences surrounding cystine residues in horse growth hormones, which will provide a greater understanding of how these hormones function and possibly lead to breakthroughs in veterinary medicine.
  • By comparing these sequences with growth hormones from other species, researchers can gain a better understanding of the evolution of these hormones, potentially aiding in the development of therapeutic strategies for hormone-related health issues across different species.

Cite This Article

APA
Oliver L, Hartree AS. (1968). Amino acid sequences around the cystine residues in horse growth hormone. Biochem J, 109(1), 19-24. https://doi.org/10.1042/bj1090019

Publication

The Biochemical journal
ISSN: 0264-6021
NlmUniqueID: 2984726R
Country: England
Language: English
Volume: 109
Issue: 1
Pages: 19-24

Researcher Affiliations

Oliver, L
    Hartree, A S

      MeSH Terms

      • Amino Acid Sequence
      • Amino Acids / analysis
      • Animals
      • Cattle
      • Chromatography, Paper
      • Chymotrypsin
      • Cystine
      • Electrophoresis
      • Endopeptidases
      • Growth Hormone / analysis
      • Horses
      • Humans
      • Imines
      • Pepsin A
      • Peptides / analysis
      • Species Specificity
      • Trypsin

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      This article has been cited 0 times.
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