An evaluation of ethyl-6-ethoxybenzothiazole-2-carbamate (Sch 18099) for anthelmintic activity in domestic animals.

The research article investigates the effectiveness of Ethyl-6-ethoxybenzothiazole-2-carbamate (Sch 18099), a potential anthelmintic drug, against worm infections in various domestic animals.

Objective and Methodology

• The objective of the study was to investigate the anthelmintic (worm-expelling) activity of a compound called Ethyl-6-ethoxybenzothiazole-2-carbamate, also referred to as Sch 18099.
• The research was conducted on various domestic animals, namely: ponies, pigs, lambs, and chickens, all of which had natural helminth (worm) infections.
• The efficacy and effectivity of Sch 18099 was tested at various dosages, and the response of different worm species to this compound were meticulously monitored and evaluated.

Results on Ponies

• In ponies, evaluations of Sch 18099 were conducted at dosages ranging from 15 to 150 mg/kg.
• When given at a dose of 15 mg/kg, a high efficacy of over 90% was observed against Oxyuris equi and small strongyles.
• A dosage of 20 mg/kg proved 95% effective against Strongylus vulgaris and S. edentatus.
• However, the drug experienced reduced efficacy against Parascaris equorum (77%) at a greater concentration of 100 mg/kg.
• Furthermore, it showed no effectiveness against Gastrophilus spp. or Anoplocephala spp.

Results on Pigs

• In contrast to ponies, single oral doses ranging from 10 to 100 mg/kg given to pigs were not effective.
• An increased concentration of 500 ppm in the diet over seven days resulted in 100% efficacy against Ascaris suum and Trichuris suis.
• A slightly reduced concentration of 250 ppm still yielded 77% effectiveness against A. suum.
• In stark contrast, the drug had no effect against Stongyloides ransomi.

Results on Lambs and Chickens

• In lambs, a dosage of 200 mg/kg resulted to over 90% efficacy against various species like Haemonchus contortus, Trichostrongylus axei, plus others.
• Efficacy was below 80% for species like Trichostrongylus vitrinus, Nematodirus filicollis, among others.
• For chickens, a range of efficacies (14.3-89%) against Ascaridia galli were observed with dietary levels of Sch 18099 from 125-1000 ppm fed over a span of seven days.
• Sch 18099 also recorded a 100% efficacy rate against Heterakis gallinarum at the 1000 ppm dietary drug level for chickens.

Conclusion

• The study concluded that Sch 18099 demonstrated varying degrees of anthelmintic activity against many helminth infections in different domestic animals, and at different dosages.
• The results suggest the need for further optimization to determine the appropriate dosage for each particular species and each type of helminth infection.