Analysis of coagulation proteins as acute-phase reactants in horses with colic.
Abstract: To measure coagulation factor VIII:coagulant (F.VIII:C) and C1-esterase inhibitor (C1-INH), hemostasis-associated acute-phase reactant proteins and coagulation factors VII (F.VII), IX (F.IX), and X (F.X), hemostasis proteins not associated with an acute-phase response, in a select population of horses with colic and hemostasis abnormalities, and presumed to have acute-phase changes. To compare these values and other routine hemostasis test results in the horses with colic with values for a population of healthy horses. To correlate the values of known equine acute-phase reactants, F.VIII:C and fibrinogen, to those of other tests of hemostasis. To identify hemostasis-associated acute-phase reactant proteins and gain insights into the effects the acute-phase response has on hemostatic abnormalities in horses with colic syndrome. Methods: 54 plasma samples from horses with colic attributable to inflammatory (n = 39) or strangulating (n = 15) intestinal disorders. Methods: Plasma samples were evaluated for activities of F.VII, F.VIII:C, F.IX, F.X, C1-INH, antithrombin III, protein C, plasminogen, and alpha 2-antiplasmin (alpha 2AP); fibrinogen concentration; and prothrombin (PT) and activated partial thromboplastin (APTT) times. Results: Horses with colic had significantly higher fibrinogen concentration, greater alpha 2AP and protein C activities, and longer PT and APTT than did healthy horses. Horses with colic also had significantly lower mean F.VII activity than did healthy horses. Significant positive correlations between fibrinogen concentration and F.VIII:C, C1-INH, and alpha 2AP values, and between F.VIII:C activity and fibrinogen, C1-INH, alpha 2AP, and plasminogen values were identified. Conclusions: An acute-phase response contributes to changes observed in coagulation proteins in horses with colic attributable to inflammatory and strangulating intestinal disorders. The data suggest that plasminogen, alpha 2AP, and C1-INH, should be considered equine acute-phase proteins.
Publication Date: 1998-05-16 PubMed ID: 9582953
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- Non-P.H.S.
Summary
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This research investigates the changes in coagulation proteins, relevant to blood clotting, in horses with colic. The objective is to gain insights into the acute-phase response—an immediate defense mechanism of the body during inflammation—and its effects on blood-clotting abnormalities observed in horses with colic.
Objective
- The objective of the study was to evaluate and compare coagulation indices in healthy horses and those diagnosed with colic, presumed to have acute-phase inflammatory changes.
Methods
- The researchers used 54 plasma samples from horses suffering from colic, attributing the cause to either inflammatory or strangulating intestinal disorders. The study focused on the measurement of three coagulation factors (F.VII, F.IX, and F.X), two acute-phase reactant proteins (F.VIII:C and C1-INH), and other hemostasis-related factors.
- Plasma samples were analyzed for these coagulation factors, including hemostasis proteins and other related elements like fibrinogen concentration and prothrombin and activated partial thromboplastin times.
Results
- Findings resulted in significantly higher fibrinogen concentration, greater alpha 2AP and protein C activities, and extended prothrombin and partial thromboplastin times in colic-affected horses compared to healthy horses. These horses also had significantly lower F.Vii activity.
- Significant positive correlations were identified between fibrinogen concentration and F.VIII:C, C1-INH, and alpha 2AP values, and between F.VIII:C activity and fibrinogen, C1-INH, alpha 2AP, and plasminogen values.
Conclusions
- The results concluded that the changes in coagulation proteins observed in horses with colic are due to the acute-phase response.
- The research suggests that plasminogen, alpha 2AP, and C1-INH should be considered as equine acute-phase proteins, in addition to the traditionally recognized fibrinogen and F.VIII:C.
- This study indicates that more work is needed to fully understand the interaction of the acute-phase response and coagulation abnormalities in horses with colic and that these findings may aid in developing more effective therapeutic strategies.
Cite This Article
APA
Topper MJ, Prasse KW.
(1998).
Analysis of coagulation proteins as acute-phase reactants in horses with colic.
Am J Vet Res, 59(5), 542-545.
Publication
Researcher Affiliations
- Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
MeSH Terms
- Acute-Phase Proteins / analysis
- Animals
- Blood Coagulation Factors / analysis
- Colic / blood
- Colic / veterinary
- Complement C1 Inactivator Proteins / analysis
- Horse Diseases / blood
- Horses
- Inflammatory Bowel Diseases / blood
- Inflammatory Bowel Diseases / veterinary
- Intestinal Obstruction / blood
- Intestinal Obstruction / veterinary
Citations
This article has been cited 2 times.- Blangy-Letheule A, Vergnaud A, Dupas T, Rozec B, Lauzier B, Leroux AA. Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives.. Cells 2023 Mar 30;12(7).
- Pihl TH, Scheepers E, Sanz M, Goddard A, Page P, Toft N, Andersen PH, Jacobsen S. Influence of disease process and duration on acute phase proteins in serum and peritoneal fluid of horses with colic.. J Vet Intern Med 2015 Mar-Apr;29(2):651-8.
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