Anesthetic management with sevoflurane combined with alfaxalone-medetomidine constant rate infusion in a Thoroughbred racehorse undergoing a long-time orthopedic surgery.
Abstract: A three-year old Thoroughbred racehorse was anesthetized with sevoflurane and oxygen inhalation anesthesia combined with constant rate infusion (CRI) of alfaxalone-medetomidine for internal fixation of a third metacarpal bone fracture. After premedication with intravenous (IV) injections of medetomidine (6.0 µg/kg IV), butorphanol (25 µg/kg IV), and midazolam (20 µg/kg IV), anesthesia was induced with 5% guaifenesin (500 ml/head IV) followed immediately by alfaxalone (1.0 mg/kg IV). Anesthesia was maintained with sevoflurane and CRIs of alfaxalone (1.0 mg/kg/hr) and medetomidine (3.0 µg/kg/hr). The total surgical time was 180 min, and the total inhalation anesthesia time was 230 min. The average end-tidal sevoflurane concentration during surgery was 1.8%. The mean arterial blood pressure was maintained above 70 mmHg throughout anesthesia, and the recovery time was 65 min. In conclusion, this anesthetic technique may be clinically applicable for Thoroughbred racehorses undergoing a long-time orthopedic surgery.
Publication Date: 2017-09-20 PubMed ID: 28955163PubMed Central: PMC5608964DOI: 10.1294/jes.28.111Google Scholar: Lookup
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Summary
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This study examines the efficacy of a combined anaesthetic approach, using sevoflurane, alfaxalone and medetomidine, on a Thoroughbred racehorse undergoing a lengthy orthopaedic surgery.
Methodology
- The subject of the study was a three-year old Thoroughbred racehorse. The horse required internal fixation of a fractured third metacarpal bone.
- Anesthesia was administered using a mixed method which involved sevoflurane and oxygen inhalation, combined with constant rate infusion (CRI) of alfaxalone-medetomidine.
- Prior to the racehorse undergoing anesthesia, premedication was given which included intravenous (IV) injections of medetomidine, butorphanol and midazolam. The anesthesia was then induced with 5% guaifenesin followed by alfaxalone.
Anesthesia Maintenance and Surgical Time
- Anesthesia was maintained using sevoflurane and a CRI of alfaxalone and medetomidine. The parameters for the CRIs of alfaxalone and medetomidine were 1.0 mg/kg/hr and 3.0 µg/kg/hr respectively.
- The total surgical time recorded was 180 minutes. The total inhalation anesthesia time was longer at 230 minutes.
- The average end-tidal sevoflurane concentration during surgery was 1.8%, signifying adequate depth of anesthesia throughout the procedure.
Post-surgery observations and conclusion
- Measurements during the procedure showed that the racehorse’s mean arterial blood pressure was maintained above 70 mmHg throughout anesthesia.
- The recovery time for the racehorse was 65 minutes, which was considered appropriate for a procedure of this magnitude.
- Based on the stability of the racehorse’s vital signs, the depth of anesthesia, and the recovery period, it was concluded that the anesthetic technique used in this study could be clinically applicable for Thoroughbred racehorses undergoing lengthy orthopedic surgeries.
Cite This Article
APA
Wakuno A, Maeda T, Kodaira K, Kikuchi T, Ohta M.
(2017).
Anesthetic management with sevoflurane combined with alfaxalone-medetomidine constant rate infusion in a Thoroughbred racehorse undergoing a long-time orthopedic surgery.
J Equine Sci, 28(3), 111-115.
https://doi.org/10.1294/jes.28.111 Publication
Researcher Affiliations
- Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
- Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
- Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
- Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
- Racehorse Clinic, Miho Training Center, Japan Racing Association, Ibaraki 300-0493, Japan.
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This article includes 24 references
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Citations
This article has been cited 2 times.- Gozalo-Marcilla M, Ringer SK. Recovery after General Anaesthesia in Adult Horses: A Structured Summary of the Literature.. Animals (Basel) 2021 Jun 14;11(6).
- Qu L, Jiang H. Clinical Efficacy of Trimetazidine and Holistic Management in the Treatment of Coronary Heart Disease.. Iran J Public Health 2018 Jun;47(6):824-829.
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