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Home / Equine Research Bank / J Endocrinol / Anti-Müllerian hormone and ovarian aging in mares.
The Journal of endocrinology2018; 240(2); 147-156; doi: 10.1530/JOE-18-0391

Anti-Müllerian hormone and ovarian aging in mares.

Abstract: Anti-Müllerian hormone (AMH) is used as a marker of follicle population numbers and potential fertility in several species including horses but limited data exist across the lifespan. No one has decreased ovarian reserve experimentally to investigate whether a corresponding, quantitative decrease in AMH results. Concentrations of AMH across the lifespan were compiled from 1101 equine females sampled from birth to >33 years of age. Young and old mares (averaging 6 and 19 years) were hemi-ovariectomized and circulating AMH was assessed before and daily thereafter for 15 days. The remaining ovary was removed later and blood was drawn again before and after this second surgery for AMH determination. Polynomial regression analysis and analysis of mares grouped by 5-year intervals of age demonstrated AMH concentrations to be higher in mares aged 5-10 and 10-15 years than 0-5 years of age and lower in mares after 20 years of age. There was high variability in AMH concentrations among neonatal fillies, some of which had concentrations typical of males. Hemi-ovariectomy was followed by a decrease of AMH, almost exactly halving concentrations in intact mares. Concentrations of AMH had returned to intact levels in old mares before complete ovariectomy, as if exhibiting ovarian compensatory hypertrophy, but recovery of AMH was not evident in young mares. AMH may reflect ovarian senescence in mares after 20 years of age but is too variable to do so in the first two decades of life. The ovarian endocrine response to hemi-ovariectomy in mares appears to change with age.
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Publication Date: 2018-11-08 PubMed ID: 30400031DOI: 10.1530/JOE-18-0391Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The article is about a research study investigating the role of Anti-Müllerian hormone (AMH) in the aging process of mares (female horses). Through various procedures and age group analyses, the researchers found that AMH levels could reflect ovarian aging for mares older than 20 years. However, it was too varying to reflect the same for mares in the first two decades of their lives.

Study Design and Participants

  • The study was conducted with 1101 female horses ranging from birth to over 33 years of age.
  • These mares’ AMH levels were monitored to understand its correlation with the mare’s age and ovarian fitness.
  • The study also involved a surgical process (hemi-ovariectomy) on young and old mares (averaging 6 and 19 years) and their resultant AMH levels were recorded for 15 consecutive days.
  • The remaining ovary was later removed and AMH levels in the blood were assessed before and after this second procedure.

Observations and Results

  • The data were analyzed by Polynomial regression analysis and the mares were sorted into 5-year age groups.
  • It was observed that AMH concentrations were higher in mares aged 5-10 and 10-15 years than those aged 0-5 years, and lower in mares over 20 years of age.
  • The study found significant variability in AMH levels among newborn fillies, with some reaching levels typically seen in males.
  • The surgical removal of one ovary (hemi-ovariectomy) resulted in a decrease in AMH levels, halving concentrations in intact mares.

Specific Findings and Conclusions

  • An interesting observation was the recovery of AMH to pre-hemi-ovariectomy levels in older mares before full ovary removal, indicating potential ovarian compensatory hypertrophy. However, this recovery was not observed in the younger mares.
  • The study concluded that AMH levels could serve as an indicator of ovarian aging in mares over 20 years of age. However, it was too inconsistent in the first two decades of life in mares.
  • The research suggests that the ovarian endocrine response in mares to the removal of an ovary might change with age.

Cite This Article

APA
Uliani RC, Conley AJ, Corbin CJ, Friso AM, Maciel LFS, Alvarenga MA. (2018). Anti-Müllerian hormone and ovarian aging in mares. J Endocrinol, 240(2), 147-156. https://doi.org/10.1530/JOE-18-0391

Publication

The Journal of endocrinology
ISSN: 1479-6805
NlmUniqueID: 0375363
Country: England
Language: English
Volume: 240
Issue: 2
Pages: 147-156

Researcher Affiliations

Uliani, Renata C
  • Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Conley, Alan J
  • Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Corbin, C Jo
  • Department of Population Health and Reproduction, School of Veterinary Medicine, University of California Davis, Davis, California, USA.
Friso, Aimê M
  • Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Maciel, Luciana F S
  • Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.
Alvarenga, Marco A
  • Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil.

MeSH Terms

  • Aging / physiology
  • Animals
  • Animals, Newborn
  • Anti-Mullerian Hormone / blood
  • Female
  • Horses
  • Humans
  • Male
  • Ovarian Follicle / physiology
  • Ovarian Reserve / physiology
  • Ovariectomy
  • Ovary / physiology

Citations

This article has been cited 6 times.
  1. Ren W, Wang J, Zeng Y, Wang T, Meng J, Yao X. Differential age-related transcriptomic analysis of ovarian granulosa cells in Kazakh horses. Front Endocrinol (Lausanne) 2024;15:1346260.
    doi: 10.3389/fendo.2024.1346260pubmed: 38352714google scholar: lookup
  2. Camp OG, Bembenek JN, Goud PT, Awonuga AO, Abu-Soud HM. The Implications of Insufficient Zinc on the Generation of Oxidative Stress Leading to Decreased Oocyte Quality. Reprod Sci 2023 Jul;30(7):2069-2078.
    doi: 10.1007/s43032-023-01212-0pubmed: 36920672google scholar: lookup
  3. Drozdzewska K, Gehlen H. Markers for internal neoplasia in the horse. Vet Med Sci 2023 Jan;9(1):132-143.
    doi: 10.1002/vms3.1042pubmed: 36495211google scholar: lookup
  4. Lu H, Ma L, Zhang Y, Feng Y, Zhang J, Wang S. Current Animal Model Systems for Ovarian Aging Research. Aging Dis 2022 Jul 11;13(4):1183-1195.
    doi: 10.14336/AD.2021.1209pubmed: 35855343google scholar: lookup
  5. Papas M, Govaere J, Peere S, Gerits I, Van de Velde M, Angel-Velez D, De Coster T, Van Soom A, Smits K. Anti-Müllerian Hormone and OPU-ICSI Outcome in the Mare. Animals (Basel) 2021 Jul 5;11(7).
    doi: 10.3390/ani11072004pubmed: 34359132google scholar: lookup
  6. Umer S, Zhao SJ, Sammad A, Weldegebriall Sahlu B, Yunwei P, Zhu H. AMH: Could It Be Used as A Biomarker for Fertility and Superovulation in Domestic Animals?. Genes (Basel) 2019 Dec 4;10(12).
    doi: 10.3390/genes10121009pubmed: 31817280google scholar: lookup
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