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Home / Equine Research Bank / Vet Microbiol / Antibacterial activity of cefquinome against equine bacteria...
Veterinary microbiology2006; 115(1-3); 140-147; doi: 10.1016/j.vetmic.2005.12.019

Antibacterial activity of cefquinome against equine bacterial pathogens.

Abstract: Cefquinome is known for its use as an antibacterial drug in cattle and pigs. The objective of this study was to evaluate the antibacterial activity of cefquinome against equine pathogenic bacteria. The minimum inhibitory concentration (MIC) of cefquinome was determined for a total of 205 strains, which had recently been isolated in Europe from diseased horses (respiratory infection, foal septicaemia). The bactericidal activity was tested against 19 strains using the time killing method. The post-antibiotic effect (PAE) and post-antibiotic sub-MIC effect (PA SME) were determined against 12 strains. Cefquinome showed high activity against Actinobacillus equuli and streptococci (MIC(90) of 0.016 and 0.032microg/mL), Enterobacteriaceae (MIC(90)=0.125microg/mL) and staphylococci (MIC(90)=0.5microg/mL). The activity was limited against Rhodococcus spp. and Pseudomonas spp. Cefquinome was shown to be a time dependent bactericidal antibiotic against the target pathogens, killing occurring at a concentration close to the MIC. A PAE of 0.5-10h was calculated against streptococci whereas no PAE was observed for Escherichia coli. A longer PA SME was determined for streptococci (3.3 to >24h with a killing effect) and E. coli (0.5-13.9h). Cefquinome was shown to have a broad spectrum of activity which covers many equine pathogens.
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Publication Date: 2006-02-07 PubMed ID: 16455213DOI: 10.1016/j.vetmic.2005.12.019Google Scholar: Lookup
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Summary

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The research article discusses a study evaluating the antibacterial activity of a drug named Cefquinome against bacteria that cause diseases in horses.

Introduction and Objective

  • The research work aims to assess the impact of the antibacterial drug Cefquinome on pathogenic bacteria in horses. Cefquinome is a drug currently used to treat bacterial infections in cattle and pigs, and this study aims to understand its effectiveness for similar cases in horses.

Methodology

  • The researchers evaluated the effect of Cefquinome by determining its Minimum Inhibitory Concentration (MIC) on 205 bacterial strains previously isolated from horses suffering from diseases like respiratory infections and foal septicaemia in Europe. MIC is the lowest concentration of the antibiotic that inhibits the growth of the bacteria.
  • They tested the bactericidal activity (ability to kill bacteria) of Cefquinome on 19 of these strains, using a method known as the time-killing method.
  • The post-antibiotic effects (PAE) and the post-antibiotic sub-MIC effects (PA SME) were determined against 12 bacterial strains. PAE is the continued suppression of bacterial growth after brief exposure to an antibiotic. PA SME refers to the ongoing suppression of bacterial growth at antibiotic concentrations below the MIC.

Results and Conclusions

  • Cefquinome showed considerable efficacy against different types of bacteria, including Actinobacillus equuli, streptococci, Enterobacteriaceae, and staphylococci, as evidenced by a low MIC.
  • However, the drug showed limited activity against Rhodococcus species and Pseudomonas species.
  • It displayed a time-dependent bactericidal effect on the target pathogens, where killing occurred near the MIC level.
  • A PAE ranging from 0.5 – 10 hours was observed for streptococci, whereas there was no PAE observed for the Escherichia coli strain.
  • A longer post-antibiotic sub-MIC effect was observed for streptococci (from 3.3 to up to 24 hours) and for E. coli (between 0.5 and 13.9 hours).
  • In conclusion, Cefquinome demonstrated a wide-ranging impact, covering many types of equine pathogens, indicating its potential as a broad-spectrum antibiotic in equine therapy.

Cite This Article

APA
Thomas E, Thomas V, Wilhelm C. (2006). Antibacterial activity of cefquinome against equine bacterial pathogens. Vet Microbiol, 115(1-3), 140-147. https://doi.org/10.1016/j.vetmic.2005.12.019

Publication

Veterinary microbiology
ISSN: 0378-1135
NlmUniqueID: 7705469
Country: Netherlands
Language: English
Volume: 115
Issue: 1-3
Pages: 140-147

Researcher Affiliations

Thomas, E
  • Intervet Innovation GmbH, Zur Propstei, D-55270 Schwabenheim, Germany. emmanuel.thomas@intervet.com
Thomas, V
    Wilhelm, C

      MeSH Terms

      • Animals
      • Anti-Bacterial Agents / pharmacology
      • Bacteria / drug effects
      • Bacterial Infections / drug therapy
      • Bacterial Infections / microbiology
      • Bacterial Infections / veterinary
      • Cephalosporins / pharmacology
      • Colony Count, Microbial / veterinary
      • Dose-Response Relationship, Drug
      • Drug Resistance, Bacterial
      • Horse Diseases / drug therapy
      • Horse Diseases / microbiology
      • Horses
      • Microbial Sensitivity Tests / veterinary
      • Time Factors

      Citations

      This article has been cited 14 times.
      1. Liu C, Han M, Wang H, Chen X, Tang Y, Zhang D, Li X, Liu Y. Elimination of Cefquinome Sulfate Residue in Cow's Milk after Intrauterine Infusion. Metabolites 2023 Mar 29;13(4).
        doi: 10.3390/metabo13040492pubmed: 37110151google scholar: lookup
      2. Tyrnenopoulou P, Fthenakis GC. Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids. Antibiotics (Basel) 2023 Mar 28;12(4).
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        doi: 10.2147/IJN.S348822pubmed: 35677677google scholar: lookup
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      7. Elbadawy M, Soliman A, Abugomaa A, Alkhedaide A, Soliman MM, Aboubakr M. Disposition of Cefquinome in Turkeys (Meleagris gallopavo) Following Intravenous and Intramuscular Administration. Pharmaceutics 2021 Oct 28;13(11).
        doi: 10.3390/pharmaceutics13111804pubmed: 34834219google scholar: lookup
      8. Lee DH, Birhanu BT, Lee EB, Lee SJ, Boby N, Park YS, Park SC. Pharmacokinetic and pharmacodynamic integration for optimal dosage of cefquinome against Streptococcus equi subsp. equi in foals. Vet Res 2020 Oct 15;51(1):131.
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      10. El-Hewaity M, Abd El Latif A, Soliman A, Aboubakr M. Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) following Repeated Intramuscular Administrations in Sheep and Goats. J Vet Med 2014;2014:949642.
        doi: 10.1155/2014/949642pubmed: 26464946google scholar: lookup
      11. Dinakaran V, Dumka VK, Ranjan B, Balaje R, Sidhu PK. Pharmacokinetics following intravenous administration and pharmacodynamics of cefquinome in buffalo calves. Trop Anim Health Prod 2013 Oct;45(7):1509-12.
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      12. Uney K, Altan F, Elmas M. Development and validation of a high-performance liquid chromatography method for determination of cefquinome concentrations in sheep plasma and its application to pharmacokinetic studies. Antimicrob Agents Chemother 2011 Feb;55(2):854-9.
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      13. Uslu M, Corum O, Yazar E. Effect of Meloxicam on the Pharmacokinetics of Cefquinome in Endotoxemic Sheep. Vet Med Sci 2025 Sep;11(5):e70462.
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      14. Li C, Wang J, Guo F, Zhang F, Chen B, Wang Z, Cao D, Yu Z. Pharmacokinetic and pharmacodynamic integration and resistance analysis of cefquinome against Streptococcus uberis in vitro dynamic model. Front Microbiol 2025;16:1533892.
        doi: 10.3389/fmicb.2025.1533892pubmed: 40771689google scholar: lookup
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