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Home / Equine Research Bank / Can Vet J / Antibodies against equine herpesvirus 1 in the cerebrospinal...
The Canadian veterinary journal = La revue veterinaire canadienne1985; 26(7); 218-220;

Antibodies against equine herpesvirus 1 in the cerebrospinal fluid in the horse.

Abstract: Neutralizing antibodies against equine herpesvirus 1 were measured in serum and cerebrospinal fluid of 16 horses and ponies from a closed herd both before and after vaccination with modified live equine herpesvirus 1. These titers were also measured in 22 neurologically normal and 15 neurologically abnormal horses at a teaching hospital. Animals from the closed herd had prevaccination serum titers up to 1:8 and postvaccination serum titers up to 1:128. Horses from the teaching hospital had serum titers up to 1:64. Cerebrospinal fluid titers were not detected in the vaccinated horses or the neurologically normal horses but a low titer (1:8) was noted in one neurologically abnormal horse. This titer probably resulted from hemorrhage into the cerebrospinal fluid following trauma.
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Publication Date: 1985-07-01 PubMed ID: 17422553PubMed Central: PMC1680092
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research work studies the levels of antibodies against equine herpesvirus 1 in horses’ blood and cerebrospinal fluid before and after vaccination, including a group with neurological abnormalities.

Overview of the Research

  • This study aims to understand the levels of antibodies against equine herpesvirus 1 in serum (blood) and cerebrospinal fluid of horses, both before and after their vaccination with a vaccine based on the modified live equine herpesvirus 1. The research observes this antibody presence in horses from a closed herd and separately in neurologically normal and abnormal horses at a teaching hospital. The objective is to understand the interaction of the virus and its vaccination with the immune response of healthy and neurologically impaired animals.

Research Subjects and Methodology

  • The subjects for this study were 16 horses and ponies from a contained environment, referred to as a closed herd. Additionally, 22 neurologically normal and 15 neurologically abnormal horses from a teaching hospital were studied.
  • The animals from the closed herd had their serum titers, which represent the concentration of antibodies in blood, measured before and after being vaccinated with a modified live equine herpesvirus 1 vaccine. The same was done for the horses at the teaching hospital.
  • The cerebrospinal fluid from these animals was also analyzed for the presence of these antibodies.

Results and Observations

  • Before vaccination, horses from the closed herd showed a maximum serum titer of 1:8. After vaccination, their serum titers increased to a maximum of 1:128, indicating successful immunization.
  • Horses from the teaching hospital had a maximum serum titer of 1:64, without specifying if this was pre or post-vaccination.
  • Interestingly, their cerebrospinal fluid did not show any antibodies in either the vaccinated horses or the neurologically normal horses. Yet, a very low titer (1:8) was found in one neurologically abnormal horse.
  • The researchers suggest that this low presence of antibodies in the cerebrospinal fluid of the neurologically abnormal horse might be due to blood contamination following some form of trauma, rather than an immune response due to the virus or vaccine.

Cite This Article

APA
Blythe LL, Mattson DE, Lassen ED, Craig AM. (1985). Antibodies against equine herpesvirus 1 in the cerebrospinal fluid in the horse. Can Vet J, 26(7), 218-220.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 26
Issue: 7
Pages: 218-220

Researcher Affiliations

Blythe, L L
    Mattson, D E
      Lassen, E D
        Craig, A M

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          Citations

          This article has been cited 2 times.
          1. Keane DP, Little PB. Equine viral encephalomyelitis in Canada: a review of known and potential causes. Can Vet J 1987 Aug;28(8):497-504.
            pubmed: 17422841
          2. Keane DP, Little PB, Wilkie BN, Artsob H, Thorsen J. Agents of equine viral encephalomyelitis: correlation of serum and cerebrospinal fluid antibodies. Can J Vet Res 1988 Apr;52(2):229-35.
            pubmed: 2836046
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