FREE SHIPPING over $40
Horse Supplements USA English
Horse Supplements Canada EnglishSuppléments Équins Canada French
My Account
View Cart My Horses Track Orders Account Details My Subscriptions Update Address Payment Methods
Register/Login
0
Home/Equine Research Bank/Vet Microbiol/Antibodies to Berne virus in horses and other animals.
Veterinary microbiology1984; 9(6); 523-531; doi: 10.1016/0378-1135(84)90014-2

Antibodies to Berne virus in horses and other animals.

Abstract: After inoculation into 2 foals, Berne virus induced neutralizing antibody, but did not cause clinical symptoms. In a horizontal study of seropositive mares and their offspring, a decline of maternal antibodies and a sudden synchronous seroconversion in all foals were observed, again without clinical symptoms. The virus is widespread in the Swiss horse population and has been so during the last decade; rises in antibody titers were noted in 9% of paired sera sampled at random. Positive reactions were also obtained in serum neutralization tests and ELISA using small numbers of horse sera from Germany, France and the U.S.A. The results of neutralization tests and ELISA were correlated in 83% of random samples tested; 13% were neutralization-positive and ELISA-negative and in 4% the inverse was observed. Neutralizing activity was found in the sera of other ungulates (cattle, goat, sheep and pig), laboratory rabbits and 2 species of wild mice (Clethrionomys glareolus and Apodemus sylvaticus). Inconclusive results were obtained with feline and human sera; those from dogs and foxes (Vulpes vulpes) were consistently negative. The probable occurrence of antigenic variants in Berne-type viruses is discussed.
Get Full Text
Publication Date: 1984-10-01 PubMed ID: 6506447PubMed Central: PMC7117441DOI: 10.1016/0378-1135(84)90014-2Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedIn
  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about a study on the prevalence and effects of Berne virus in horses and other animals, revealing widespread infection but no clinical symptoms. It also explores the potential of antigenic variants in Berne-type viruses.

Research Methodology and Findings

  • The researchers started by inoculating two foals with the Berne virus. Observations showed the virus induced neutralizing antibody in the animals but did not cause any observable clinical symptoms.
  • A horizontal study of seropositive mares and their offspring indicated a decline of maternal antibodies in the offspring, followed by a sudden, simultaneous seroconversion in all foals. Yet again, there were no clinical symptoms observed.

Prevalence of Berne Virus

  • The research revealed that the Berne virus is widespread in Swiss horse populations and has continued to remain thus over the last decade.
  • The researchers noted increases in antibody titers in 9% of randomly sampled paired sera, indicating the virus’s presence.
  • The team also identified positive reactions to the virus in a small number of horse sera from Germany, France, and the United States, suggesting the virus is not limited to Switzerland.

Correlational Findings and Inconsistencies

  • Testing with neutralization tests and ELISA correlated in 83% of random samples tested.
  • However, 13% of the samples were neutralizing-positive but ELISA-negative, and in 4% the opposite was observed, indicating inconsistent results between the two testing methods.

Presence of Berne Virus in Other Animals

  • Neutralizing activity related to Berne virus was detected in the sera of other ungulates like cattle, goat, sheep and pig, as well as in laboratory rabbits and 2 species of wild mice (Clethrionomys glareolus and Apodemus sylvaticus).
  • Inconclusive results were obtained in cats and humans, while no evidence of the virus was found in dogs and foxes (Vulpes vulpes).

Discussion on Antigenic Variants

  • The researchers also touch upon the potential existence of antigenic variants in Berne-type viruses in their discussion. These antigenic variants could mean that there are different forms or strains of the Berne virus, which could have implications for diagnosis and treatment strategies.

Cite This Article

APA
Weiss M, Steck F, Kaderli R, Horzinek MC. (1984). Antibodies to Berne virus in horses and other animals. Vet Microbiol, 9(6), 523-531. https://doi.org/10.1016/0378-1135(84)90014-2

Publication

Veterinary microbiology
ISSN: 0378-1135
NlmUniqueID: 7705469
Country: Netherlands
Language: English
Volume: 9
Issue: 6
Pages: 523-531

Researcher Affiliations

Weiss, M
    Steck, F
      Kaderli, R
        Horzinek, M C

          MeSH Terms

          • Animals
          • Antibodies, Viral / analysis
          • Cattle / immunology
          • Enzyme-Linked Immunosorbent Assay
          • Female
          • Goats / immunology
          • Horse Diseases / epidemiology
          • Horses / immunology
          • Neutralization Tests
          • RNA Viruses / immunology
          • Sheep / immunology
          • Swine / immunology
          • Switzerland
          • Virus Diseases / epidemiology
          • Virus Diseases / veterinary

          References

          This article includes 9 references
          1. Avrameas S., Ternyck T., Guesdon S.L. Coupling of enzymes to antibodies and antigens. Scand. J. Immunol. 1978;8(Suppl. 7):7u201323.
          2. Engvall E, Perlmann P. Enzyme-linked immunosorbent assay, Elisa. 3. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes.. J Immunol 1972 Jul;109(1):129-35.
            pubmed: 4113792
          3. Horzinek MC, Lutz H, Pedersen NC. Antigenic relationships among homologous structural polypeptides of porcine, feline, and canine coronaviruses.. Infect Immun 1982 Sep;37(3):1148-55.
            pmc: PMC347660pubmed: 6182101doi: 10.1128/iai.37.3.1148-1155.1982google scholar: lookup
          4. Horzinek MC, Weiss M, Ederveen J. Berne virus is not 'coronavirus-like'.. J Gen Virol 1984 Mar;65 ( Pt 3):645-9.
            pubmed: 6699624doi: 10.1099/0022-1317-65-3-645google scholar: lookup
          5. Pass DA, Penhale WJ, Wilcox GE, Batey RG. Intestinal coronavirus-like particles in sheep with diarrhoea.. Vet Rec 1982 Jul 31;111(5):106-7.
            pubmed: 7123829doi: 10.1136/vr.111.5.106google scholar: lookup
          6. Saif L.J., Redman D.R., Theil K.W., Moorhead P.D., Smith C.K. 62nd Annu. Meet. Conf. Res. Workers Anim. Dis., Abstr. 1981. Studies of an enteric u201cBredau201d virus in calves; p. 236.
          7. Steck F, Lazary S, Fey H, Wandeler A, Huggler C, Oppliger G, Baumberger H, Kaderli R, Martig J. Immune responsiveness in cattle fatally affected by bovine virus diarrhea-mucosal disease.. Zentralbl Veterinarmed B 1980;27(6):429-45.
            pubmed: 6258359doi: 10.1111/j.1439-0450.1980.tb01790.xgoogle scholar: lookup
          8. Weiss M, Steck F, Horzinek MC. Purification and partial characterization of a new enveloped RNA virus (Berne virus).. J Gen Virol 1983 Sep;64 (Pt 9):1849-58.
            pubmed: 6886677doi: 10.1099/0022-1317-64-9-1849google scholar: lookup
          9. Woode GN, Reed DE, Runnels PL, Herrig MA, Hill HT. Studies with an unclassified virus isolated from diarrheic calves.. Vet Microbiol 1982 Jul;7(3):221-40.
            pmc: PMC7117454pubmed: 7051518doi: 10.1016/0378-1135(82)90036-0google scholar: lookup

          Citations

          This article has been cited 26 times.
          1. Eruera AR, McSweeney AM, McKenzie-Goldsmith GM, Ward VK. Protein Nucleotidylylation in +ssRNA Viruses.. Viruses 2021 Aug 5;13(8).
            doi: 10.3390/v13081549pubmed: 34452414google scholar: lookup
          2. Ujike M, Taguchi F. Recent Progress in Torovirus Molecular Biology.. Viruses 2021 Mar 8;13(3).
            doi: 10.3390/v13030435pubmed: 33800523google scholar: lookup
          3. Xu S, Zhou J, Chen Y, Tong X, Wang Z, Guo J, Chen J, Fang L, Wang D, Xiao S. Characterization of Self-Processing Activities and Substrate Specificities of Porcine Torovirus 3C-Like Protease.. J Virol 2020 Sep 29;94(20).
            doi: 10.1128/JVI.01282-20pubmed: 32727876google scholar: lookup
          4. Li H, Zhang B, Yue H, Tang C. First detection and genomic characteristics of bovine torovirus in dairy calves in China.. Arch Virol 2020 Jul;165(7):1577-1583.
            doi: 10.1007/s00705-020-04657-9pubmed: 32388597google scholar: lookup
          5. Petric M. VI, 1. Epidemiology of toroviruses.. Perspect Med Virol 2003;9:625-632.
            doi: 10.1016/S0168-7069(03)09038-4pubmed: 32287605google scholar: lookup
          6. Hu ZM, Yang YL, Xu LD, Wang B, Qin P, Huang YW. Porcine Torovirus (PToV)-A Brief Review of Etiology, Diagnostic Assays and Current Epidemiology.. Front Vet Sci 2019;6:120.
            doi: 10.3389/fvets.2019.00120pubmed: 31058174google scholar: lookup
          7. Alonso-Padilla J, Pignatelli J, Simon-Grifu00e9 M, Plazuelo S, Casal J, Rodru00edguez D. Seroprevalence of porcine torovirus (PToV) in Spanish farms.. BMC Res Notes 2012 Dec 5;5:675.
            doi: 10.1186/1756-0500-5-675pubmed: 23217216google scholar: lookup
          8. Aita T, Kuwabara M, Murayama K, Sasagawa Y, Yabe S, Higuchi R, Tamura T, Miyazaki A, Tsunemitsu H. Characterization of epidemic diarrhea outbreaks associated with bovine torovirus in adult cows.. Arch Virol 2012 Mar;157(3):423-31.
            doi: 10.1007/s00705-011-1183-9pubmed: 22167249google scholar: lookup
          9. Pignatelli J, Grau-Roma L, Jimu00e9nez M, Segalu00e9s J, Rodru00edguez D. Longitudinal serological and virological study on porcine torovirus (PToV) in piglets from Spanish farms.. Vet Microbiol 2010 Dec 15;146(3-4):260-8.
            doi: 10.1016/j.vetmic.2010.05.023pubmed: 20542392google scholar: lookup
          10. Pignatelli J, Jimenez M, Luque J, Rejas MT, Lavazza A, Rodriguez D. Molecular characterization of a new PToV strain. Evolutionary implications.. Virus Res 2009 Jul;143(1):33-43.
            doi: 10.1016/j.virusres.2009.02.019pubmed: 19463719google scholar: lookup
          11. Kuwabara M, Wada K, Maeda Y, Miyazaki A, Tsunemitsu H. First isolation of cytopathogenic bovine torovirus in cell culture from a calf with diarrhea.. Clin Vaccine Immunol 2007 Aug;14(8):998-1004.
            doi: 10.1128/CVI.00475-06pubmed: 17567770google scholar: lookup
          12. Draker R, Roper RL, Petric M, Tellier R. The complete sequence of the bovine torovirus genome.. Virus Res 2006 Jan;115(1):56-68.
            doi: 10.1016/j.virusres.2005.07.005pubmed: 16137782google scholar: lookup
          13. Smits SL, Lavazza A, Matiz K, Horzinek MC, Koopmans MP, de Groot RJ. Phylogenetic and evolutionary relationships among torovirus field variants: evidence for multiple intertypic recombination events.. J Virol 2003 Sep;77(17):9567-77.
            doi: 10.1128/jvi.77.17.9567-9577.2003pubmed: 12915570google scholar: lookup
          14. Duckmanton L, Carman S, Nagy E, Petric M. Detection of bovine torovirus in fecal specimens of calves with diarrhea from Ontario farms.. J Clin Microbiol 1998 May;36(5):1266-70.
            doi: 10.1128/JCM.36.5.1266-1270.1998pubmed: 9574689google scholar: lookup
          15. Kroneman A, Cornelissen LA, Horzinek MC, de Groot RJ, Egberink HF. Identification and characterization of a porcine torovirus.. J Virol 1998 May;72(5):3507-11.
            doi: 10.1128/JVI.72.5.3507-3511.1998pubmed: 9557628google scholar: lookup
          16. Van Kruiningen HJ, Colombel JF, Cartun RW, Whitlock RH, Koopmans M, Kangro HO, Hoogkamp-Korstanje JA, Lecomte-Houcke M, Devred M, Paris JC. An in-depth study of Crohn's disease in two French families.. Gastroenterology 1993 Feb;104(2):351-60.
            doi: 10.1016/0016-5085(93)90401-wpubmed: 8425677google scholar: lookup
          17. Koopmans M, Petric M, Glass RI, Monroe SS. Enzyme-linked immunosorbent assay reactivity of torovirus-like particles in fecal specimens from humans with diarrhea.. J Clin Microbiol 1993 Oct;31(10):2738-44.
            doi: 10.1128/jcm.31.10.2738-2744.1993pubmed: 8253975google scholar: lookup
          18. Koopmans M, Horzinek MC. Toroviruses of animals and humans: a review.. Adv Virus Res 1994;43:233-73.
            doi: 10.1016/s0065-3527(08)60050-0pubmed: 8191955google scholar: lookup
          19. Horzinek MC. Snowdon Lecture 1993. New virus diseases: visible evolution.. Aust Vet J 1993 Dec;70(12):433-6.
            doi: 10.1111/j.1751-0813.1993.tb00843.xpubmed: 8117207google scholar: lookup
          20. Brown DW, Beards GM, Flewett TH. Detection of Breda virus antigen and antibody in humans and animals by enzyme immunoassay.. J Clin Microbiol 1987 Apr;25(4):637-40.
            doi: 10.1128/jcm.25.4.637-640.1987pubmed: 3571473google scholar: lookup
          21. Weiss M, Horzinek MC. The proposed family Toroviridae: agents of enteric infections. Brief review.. Arch Virol 1987;92(1-2):1-15.
            doi: 10.1007/BF01310058pubmed: 3541856google scholar: lookup
          22. Weiss M, Horzinek MC. Resistance of Berne virus to physical and chemical treatment.. Vet Microbiol 1986 Feb;11(1-2):41-9.
            doi: 10.1016/0378-1135(86)90005-2pubmed: 3518225google scholar: lookup
          23. Brown DW, Selvakumar R, Daniel DJ, Mathan VI. Prevalence of neutralising antibodies to Berne virus in animals and humans in Vellore, South India. Brief report.. Arch Virol 1988;98(3-4):267-9.
            doi: 10.1007/BF01322174pubmed: 3348749google scholar: lookup
          24. Beards GM, Brown DW, Green J, Flewett TH. Preliminary characterisation of torovirus-like particles of humans: comparison with Berne virus of horses and Breda virus of calves.. J Med Virol 1986 Sep;20(1):67-78.
            doi: 10.1002/jmv.1890200109pubmed: 3093635google scholar: lookup
          25. Koopmans M, van den Boom U, Woode G, Horzinek MC. Seroepidemiology of Breda virus in cattle using ELISA.. Vet Microbiol 1989 Mar;19(3):233-43.
            doi: 10.1016/0378-1135(89)90069-2pubmed: 2718353google scholar: lookup
          26. Koopmans M, Herrewegh A, Horzinek MC. Diagnosis of torovirus infection.. Lancet 1991 Apr 6;337(8745):859.
            doi: 10.1016/0140-6736(91)92573-kpubmed: 1672953google scholar: lookup

          Secure Payments

          PayPal Visa Mastercard American Express

          Satisfaction Guarantee

          We offer a 60-day guarantee to ensure you are completely satisfied.

          Fast & Free Shipping

          We provide fast and free shipping on all orders over $40.

          Use Nutrition Calculator
          Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
          Talk to a Nutritionist
          Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
          Submit Diet Evaluation
          Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists